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Associations Between Statin Treatment and Markers of Inflammation, Vasoconstriction, and Coagulation in Patients With Abdominal Aortic Aneurysm

Gottsäter, Anders LU ; Flondell-Sité, Despina LU ; Kölbel, Tilo LU and Lindblad, Bengt LU (2008) In Vascular and Endovascular Surgery 42(6). p.567-573
Abstract
The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P < .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for... (More)
The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P < .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P < .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
homocysteine, inflammation, abdominal aortic aneurysm, statins, APC-PCI, complex
in
Vascular and Endovascular Surgery
volume
42
issue
6
pages
567 - 573
publisher
SAGE Publications Inc.
external identifiers
  • wos:000261900900008
  • scopus:58149103123
ISSN
1938-9116
DOI
10.1177/1538574408320027
language
English
LU publication?
yes
id
3f441bfa-4d4b-4d73-a1d4-83902ae0c1f1 (old id 1376340)
date added to LUP
2009-04-24 12:48:48
date last changed
2017-02-12 03:35:12
@article{3f441bfa-4d4b-4d73-a1d4-83902ae0c1f1,
  abstract     = {The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P &lt; .0001). They showed lower levels of cholesterol (P &lt; .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P &lt; .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up.},
  author       = {Gottsäter, Anders and Flondell-Sité, Despina and Kölbel, Tilo and Lindblad, Bengt},
  issn         = {1938-9116},
  keyword      = {homocysteine,inflammation,abdominal aortic aneurysm,statins,APC-PCI,complex},
  language     = {eng},
  number       = {6},
  pages        = {567--573},
  publisher    = {SAGE Publications Inc.},
  series       = {Vascular and Endovascular Surgery},
  title        = {Associations Between Statin Treatment and Markers of Inflammation, Vasoconstriction, and Coagulation in Patients With Abdominal Aortic Aneurysm},
  url          = {http://dx.doi.org/10.1177/1538574408320027},
  volume       = {42},
  year         = {2008},
}