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Adsorption of cubic liquid crystalline nanoparticles on model membranes

Vandoolaeghe, Pauline LU ; Rennie, Adrian R.; Campbell, Richard LU ; Thomas, Robert K.; Höök, Fredrik LU ; Fragneto, Giovanna; Tiberg, Fredrik and Nylander, Tommy LU (2008) In Soft Matter 4(11). p.2267-2277
Abstract
The interactions of lipid based cubic liquid crystalline nanoparticles (Cubosome (R)) with surface supported model membranes constituted of dioleylphosphatidylcholine ( DOPC) have been studied in situ by use of ellipsometry, quartz crystal microbalance with dissipation monitoring and neutron reflectivity. The systems investigated were cubic phase dispersions of glycerol monooleate (GMO) stabilised by a non-ionic block copolymer, Pluronic (R) F-127. The interaction between the cubic nanoparticles and the lipid bilayer is a dynamic process where the nanoparticles initially adsorb at the bilayer surface. Interfacial lipid exchange takes place where GMO is delivered into the bilayer and DOPC is extracted into the nanoparticle (34% loss). A... (More)
The interactions of lipid based cubic liquid crystalline nanoparticles (Cubosome (R)) with surface supported model membranes constituted of dioleylphosphatidylcholine ( DOPC) have been studied in situ by use of ellipsometry, quartz crystal microbalance with dissipation monitoring and neutron reflectivity. The systems investigated were cubic phase dispersions of glycerol monooleate (GMO) stabilised by a non-ionic block copolymer, Pluronic (R) F-127. The interaction between the cubic nanoparticles and the lipid bilayer is a dynamic process where the nanoparticles initially adsorb at the bilayer surface. Interfacial lipid exchange takes place where GMO is delivered into the bilayer and DOPC is extracted into the nanoparticle (34% loss). A subsequent release of the adsorbates can be triggered when the solution concentration exceeds 0.002 mg ml(-1). The release shows that the attractive interaction between the cubic nanoparticles and lipid bilayer is unstable after sufficient exchange of material takes place. This instability is indicative of a local phase separation at the interface between the bilayer and the nanoparticles, which causes desorption of nanoparticles. Some particles remain attached to the bilayer even hours after the initial interaction. The ability to trigger the release of the nanoparticles through increasing the solution concentration offers exciting potential in the design of drug delivery aids. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
4
issue
11
pages
2267 - 2277
publisher
Royal Society of Chemistry
external identifiers
  • wos:000261733100021
  • scopus:65249188671
ISSN
1744-6848
DOI
10.1039/b801630e
language
English
LU publication?
yes
id
0559134f-e427-4ba8-8970-c646f1d4466a (old id 1377511)
date added to LUP
2009-04-24 09:51:49
date last changed
2017-01-01 05:52:23
@article{0559134f-e427-4ba8-8970-c646f1d4466a,
  abstract     = {The interactions of lipid based cubic liquid crystalline nanoparticles (Cubosome (R)) with surface supported model membranes constituted of dioleylphosphatidylcholine ( DOPC) have been studied in situ by use of ellipsometry, quartz crystal microbalance with dissipation monitoring and neutron reflectivity. The systems investigated were cubic phase dispersions of glycerol monooleate (GMO) stabilised by a non-ionic block copolymer, Pluronic (R) F-127. The interaction between the cubic nanoparticles and the lipid bilayer is a dynamic process where the nanoparticles initially adsorb at the bilayer surface. Interfacial lipid exchange takes place where GMO is delivered into the bilayer and DOPC is extracted into the nanoparticle (34% loss). A subsequent release of the adsorbates can be triggered when the solution concentration exceeds 0.002 mg ml(-1). The release shows that the attractive interaction between the cubic nanoparticles and lipid bilayer is unstable after sufficient exchange of material takes place. This instability is indicative of a local phase separation at the interface between the bilayer and the nanoparticles, which causes desorption of nanoparticles. Some particles remain attached to the bilayer even hours after the initial interaction. The ability to trigger the release of the nanoparticles through increasing the solution concentration offers exciting potential in the design of drug delivery aids.},
  author       = {Vandoolaeghe, Pauline and Rennie, Adrian R. and Campbell, Richard and Thomas, Robert K. and Höök, Fredrik and Fragneto, Giovanna and Tiberg, Fredrik and Nylander, Tommy},
  issn         = {1744-6848},
  language     = {eng},
  number       = {11},
  pages        = {2267--2277},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Adsorption of cubic liquid crystalline nanoparticles on model membranes},
  url          = {http://dx.doi.org/10.1039/b801630e},
  volume       = {4},
  year         = {2008},
}