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Monolithic cryogels with open porous structure and unique double-continuous macroporous networks

Plieva, Fatima LU ; Ekström, Peter LU ; Galaev, Igor LU and Mattiasson, Bo LU (2008) In Soft Matter 4(12). p.2418-2428
Abstract
A novel approach to create macroporous cryogels (or gels synthesized at sub-zero temperatures) with increased mechanical strength is presented. The cryogels with unique double-continuous macroporous networks were prepared via sequential freezing-thawing, when the new cryogel was synthesized inside the interconnected macropores of the preformed or primary cryogel. The prepared double-continuous macroporous cryogels (DM cryogels) have continuously interlacing networks of primary cryogel with the newly synthesized cryogels visualized by confocal laser scanning microscopy and scanning electron microscopy. The open structures of the DM cryogels with up to 150-mm-sized interconnected pores and tissue-like elasticity make them attractive as... (More)
A novel approach to create macroporous cryogels (or gels synthesized at sub-zero temperatures) with increased mechanical strength is presented. The cryogels with unique double-continuous macroporous networks were prepared via sequential freezing-thawing, when the new cryogel was synthesized inside the interconnected macropores of the preformed or primary cryogel. The prepared double-continuous macroporous cryogels (DM cryogels) have continuously interlacing networks of primary cryogel with the newly synthesized cryogels visualized by confocal laser scanning microscopy and scanning electron microscopy. The open structures of the DM cryogels with up to 150-mm-sized interconnected pores and tissue-like elasticity make them attractive as three-dimensional cell scaffolds for tissue-engineering applications. In particular, a method of preparation of macroporous cryogels with open porous structure and/or gradient porosity, increased mechanical strength and increased content of functional groups is shown. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
4
issue
12
pages
2418 - 2428
publisher
Royal Society of Chemistry
external identifiers
  • wos:000261726400016
  • scopus:54949134900
ISSN
1744-6848
DOI
10.1039/b804105a
language
English
LU publication?
yes
id
67c97ec0-dfab-4bf9-8790-2c9a3f8cedca (old id 1377521)
date added to LUP
2009-04-24 09:54:31
date last changed
2017-09-03 04:18:04
@article{67c97ec0-dfab-4bf9-8790-2c9a3f8cedca,
  abstract     = {A novel approach to create macroporous cryogels (or gels synthesized at sub-zero temperatures) with increased mechanical strength is presented. The cryogels with unique double-continuous macroporous networks were prepared via sequential freezing-thawing, when the new cryogel was synthesized inside the interconnected macropores of the preformed or primary cryogel. The prepared double-continuous macroporous cryogels (DM cryogels) have continuously interlacing networks of primary cryogel with the newly synthesized cryogels visualized by confocal laser scanning microscopy and scanning electron microscopy. The open structures of the DM cryogels with up to 150-mm-sized interconnected pores and tissue-like elasticity make them attractive as three-dimensional cell scaffolds for tissue-engineering applications. In particular, a method of preparation of macroporous cryogels with open porous structure and/or gradient porosity, increased mechanical strength and increased content of functional groups is shown.},
  author       = {Plieva, Fatima and Ekström, Peter and Galaev, Igor and Mattiasson, Bo},
  issn         = {1744-6848},
  language     = {eng},
  number       = {12},
  pages        = {2418--2428},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Monolithic cryogels with open porous structure and unique double-continuous macroporous networks},
  url          = {http://dx.doi.org/10.1039/b804105a},
  volume       = {4},
  year         = {2008},
}