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Enriched environment enhances recovery of motor function after focal ischemia in mice, and downregulates the transcription factor NGFI-A.

Nygren, Josefine LU and Wieloch, Tadeusz LU (2005) In Journal of Cerebral Blood Flow and Metabolism 25(12). p.1625-1633
Abstract
The purpose of this study was to investigate the effect of enriched environment on motor function after experimental stroke in mice, and to determine whether time in enriched environment affects functional recovery. Earlier investigations have shown that rats placed in an enriched environment after focal ischemia, remarkably improve motor function, but similar observations in mice have not been reported. In this study, we show that placing mice in an enriched environment for 3 h daily for 2 weeks, after transient (50 mins) occlusion of the middle cerebral artery, enhanced neurologic outcome. Continuous postischemic housing in the enriched environment likewise improved motor function, but mortality increased. Two weeks exposure to enriched... (More)
The purpose of this study was to investigate the effect of enriched environment on motor function after experimental stroke in mice, and to determine whether time in enriched environment affects functional recovery. Earlier investigations have shown that rats placed in an enriched environment after focal ischemia, remarkably improve motor function, but similar observations in mice have not been reported. In this study, we show that placing mice in an enriched environment for 3 h daily for 2 weeks, after transient (50 mins) occlusion of the middle cerebral artery, enhanced neurologic outcome. Continuous postischemic housing in the enriched environment likewise improved motor function, but mortality increased. Two weeks exposure to enriched environment followed by housing the mice in standard cages for 2 weeks, resulted in a loss of the improved motor function. In contrast, 4 weeks exposure to enriched environment led to an improved motor function and to a better maintenance of neurologic recovery. The expression levels of the immediate-early gene nerve growth factor-induced gene A at 2 to 3 weeks of recovery decreased in animals housed in enriched environment, implying this transcription factor in the recovery process. We conclude that housing mice in an enriched environment after experimental stroke improves functional outcome. Also, the presented experimental procedure is useful for further studies of the genomics of functional recovery after experimental stroke. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
enriched environment, stroke, NGFI-A, mice, brain plasticity
in
Journal of Cerebral Blood Flow and Metabolism
volume
25
issue
12
pages
1625 - 1633
publisher
Nature Publishing Group
external identifiers
  • wos:000235939600006
  • pmid:15917744
  • scopus:28044468869
ISSN
1559-7016
DOI
10.1038/sj.jcbfm.9600157
language
English
LU publication?
yes
id
ab5f8138-7e7c-48a9-81df-0895fd994240 (old id 137808)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15917744&dopt=Abstract
date added to LUP
2007-07-16 15:23:27
date last changed
2017-08-27 05:38:12
@article{ab5f8138-7e7c-48a9-81df-0895fd994240,
  abstract     = {The purpose of this study was to investigate the effect of enriched environment on motor function after experimental stroke in mice, and to determine whether time in enriched environment affects functional recovery. Earlier investigations have shown that rats placed in an enriched environment after focal ischemia, remarkably improve motor function, but similar observations in mice have not been reported. In this study, we show that placing mice in an enriched environment for 3 h daily for 2 weeks, after transient (50 mins) occlusion of the middle cerebral artery, enhanced neurologic outcome. Continuous postischemic housing in the enriched environment likewise improved motor function, but mortality increased. Two weeks exposure to enriched environment followed by housing the mice in standard cages for 2 weeks, resulted in a loss of the improved motor function. In contrast, 4 weeks exposure to enriched environment led to an improved motor function and to a better maintenance of neurologic recovery. The expression levels of the immediate-early gene nerve growth factor-induced gene A at 2 to 3 weeks of recovery decreased in animals housed in enriched environment, implying this transcription factor in the recovery process. We conclude that housing mice in an enriched environment after experimental stroke improves functional outcome. Also, the presented experimental procedure is useful for further studies of the genomics of functional recovery after experimental stroke.},
  author       = {Nygren, Josefine and Wieloch, Tadeusz},
  issn         = {1559-7016},
  keyword      = {enriched environment,stroke,NGFI-A,mice,brain plasticity},
  language     = {eng},
  number       = {12},
  pages        = {1625--1633},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism},
  title        = {Enriched environment enhances recovery of motor function after focal ischemia in mice, and downregulates the transcription factor NGFI-A.},
  url          = {http://dx.doi.org/10.1038/sj.jcbfm.9600157},
  volume       = {25},
  year         = {2005},
}