Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

White matter mapping in Alzheimer's disease: A neuropathological study.

Sjöbeck, Martin LU ; Haglund, Mattias LU and Englund, Elisabet LU orcid (2006) In Neurobiology of Aging 27(5). p.673-680
Abstract
White matter disease (WMD) with pervasive non-focal subtotal tissue loss is frequently seen in Alzheimer's disease (AD) upon neuropatholooical examination. Although WMD has varying effects on AD symptoms, accurate clinical detection is difficult due partly to scarcity of correlative structural imaging and histopathological studies. Neuropathological Studies of WMD severity and distribution have been conducted earlier using semi-quantitative methods. A technique for quantifying WMD objectively in large white matter areas, based on optical density (OD) measurements oil images of scanned whole-brain sections, was developed and was validated using conventional microscopic assessment. Altogether, 16 AD cases with concomitant WMD (AD-WMD) and 9... (More)
White matter disease (WMD) with pervasive non-focal subtotal tissue loss is frequently seen in Alzheimer's disease (AD) upon neuropatholooical examination. Although WMD has varying effects on AD symptoms, accurate clinical detection is difficult due partly to scarcity of correlative structural imaging and histopathological studies. Neuropathological Studies of WMD severity and distribution have been conducted earlier using semi-quantitative methods. A technique for quantifying WMD objectively in large white matter areas, based on optical density (OD) measurements oil images of scanned whole-brain sections, was developed and was validated using conventional microscopic assessment. Altogether, 16 AD cases with concomitant WMD (AD-WMD) and 9 cases of AD without WMD (AD-only) were analysed. The OD values correlated significantly with the neuropathological severity of WMD and were significantly lower in AD-WMD than ill AD-only in frontal, frontoparietal, temporal and parietal white matter but not ill the occipital white matter, the frontal OD difference being greatest. Useful baseline information oil WMD distribution in AD to relate to in vivo imaging results was obtained. (c) 2005 Published by Elsevier Inc. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, optical density, white matter disease, dementia
in
Neurobiology of Aging
volume
27
issue
5
pages
673 - 680
publisher
Elsevier
external identifiers
  • pmid:15894407
  • wos:000237177200003
  • scopus:33645958247
  • pmid:15894407
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2005.03.007
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Pathology, (Lund) (013030000)
id
d8aa6566-c9b5-4477-8b9d-f77c6da39893 (old id 138000)
date added to LUP
2016-04-01 12:19:02
date last changed
2021-02-17 01:20:25
@article{d8aa6566-c9b5-4477-8b9d-f77c6da39893,
  abstract     = {White matter disease (WMD) with pervasive non-focal subtotal tissue loss is frequently seen in Alzheimer's disease (AD) upon neuropatholooical examination. Although WMD has varying effects on AD symptoms, accurate clinical detection is difficult due partly to scarcity of correlative structural imaging and histopathological studies. Neuropathological Studies of WMD severity and distribution have been conducted earlier using semi-quantitative methods. A technique for quantifying WMD objectively in large white matter areas, based on optical density (OD) measurements oil images of scanned whole-brain sections, was developed and was validated using conventional microscopic assessment. Altogether, 16 AD cases with concomitant WMD (AD-WMD) and 9 cases of AD without WMD (AD-only) were analysed. The OD values correlated significantly with the neuropathological severity of WMD and were significantly lower in AD-WMD than ill AD-only in frontal, frontoparietal, temporal and parietal white matter but not ill the occipital white matter, the frontal OD difference being greatest. Useful baseline information oil WMD distribution in AD to relate to in vivo imaging results was obtained. (c) 2005 Published by Elsevier Inc.},
  author       = {Sjöbeck, Martin and Haglund, Mattias and Englund, Elisabet},
  issn         = {1558-1497},
  language     = {eng},
  number       = {5},
  pages        = {673--680},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {White matter mapping in Alzheimer's disease: A neuropathological study.},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2005.03.007},
  doi          = {10.1016/j.neurobiolaging.2005.03.007},
  volume       = {27},
  year         = {2006},
}