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beta(1) integrins are not required for the maintenance of lymphocytes within intestinal epithelia.

Marsal, Jan LU ; Brakebusch, Cord; Bungartz, Gerd; Fässler, Reinhard and Agace, William LU (2005) In European Journal of Immunology 35(6). p.1805-1811
Abstract
b1 integrins are thought to play a central role in maintaining lymphocytes within

mucosal epithelia via their interactions with extracellular matrix proteins and

subepithelial cellular components within and underlying the basement membrane.

In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and

CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small

intestine were found to express functional b1 integrin and the b1 integrin a chain

partners a1, a2, and a4. Using inducible b1 integrin-knockout bone marrow-chimeric

mice we demonstrate that IEL expression of a1 and a2 but not a4 is dependent on

expression of the b1 chain. Importantly,... (More)
b1 integrins are thought to play a central role in maintaining lymphocytes within

mucosal epithelia via their interactions with extracellular matrix proteins and

subepithelial cellular components within and underlying the basement membrane.

In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and

CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small

intestine were found to express functional b1 integrin and the b1 integrin a chain

partners a1, a2, and a4. Using inducible b1 integrin-knockout bone marrow-chimeric

mice we demonstrate that IEL expression of a1 and a2 but not a4 is dependent on

expression of the b1 chain. Importantly, deletion of the b1 chain in IEL did not alter the

number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL

express functional b1 integrins, these are not required to maintain lymphocytes within

intestinal epithelia. This result is discussed in the light of conventional views of

intestinal lymphocyte homing and localization. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
T lymphocytes, Adhesion molecules, Mucosa
in
European Journal of Immunology
volume
35
issue
6
pages
1805 - 1811
publisher
John Wiley & Sons
external identifiers
  • pmid:15884052
  • wos:000229947300015
  • scopus:20844462939
ISSN
1521-4141
DOI
10.1002/eji.200425941
language
English
LU publication?
yes
id
422dc890-8af2-4c9c-a800-70c540a84a06 (old id 138067)
date added to LUP
2007-07-17 13:45:21
date last changed
2017-01-01 05:04:43
@article{422dc890-8af2-4c9c-a800-70c540a84a06,
  abstract     = {b1 integrins are thought to play a central role in maintaining lymphocytes within<br/><br>
mucosal epithelia via their interactions with extracellular matrix proteins and<br/><br>
subepithelial cellular components within and underlying the basement membrane.<br/><br>
In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and<br/><br>
CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small<br/><br>
intestine were found to express functional b1 integrin and the b1 integrin a chain<br/><br>
partners a1, a2, and a4. Using inducible b1 integrin-knockout bone marrow-chimeric<br/><br>
mice we demonstrate that IEL expression of a1 and a2 but not a4 is dependent on<br/><br>
expression of the b1 chain. Importantly, deletion of the b1 chain in IEL did not alter the<br/><br>
number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL<br/><br>
express functional b1 integrins, these are not required to maintain lymphocytes within<br/><br>
intestinal epithelia. This result is discussed in the light of conventional views of<br/><br>
intestinal lymphocyte homing and localization.},
  author       = {Marsal, Jan and Brakebusch, Cord and Bungartz, Gerd and Fässler, Reinhard and Agace, William},
  issn         = {1521-4141},
  keyword      = {T lymphocytes,Adhesion molecules,Mucosa},
  language     = {eng},
  number       = {6},
  pages        = {1805--1811},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {beta(1) integrins are not required for the maintenance of lymphocytes within intestinal epithelia.},
  url          = {http://dx.doi.org/10.1002/eji.200425941},
  volume       = {35},
  year         = {2005},
}