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Towards accurate in vivo spectroscopy of the human prostate

Svensson, Tomas LU ; Alerstam, Erik LU ; Einarsdottir, Margret; Svanberg, Katarina LU and Andersson-Engels, Stefan LU (2008) In Journal of Biophotonics 1(3). p.200-203
Abstract
The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time-of-flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in the human prostate. For the first time, we demonstrate Monte Carlo-based evaluation of in vivo TOF photon migration data. We show that this approach is crucial in order to avoid the large errors associated with the use of time-resolved diffusion theory of light propagation in prostate-like tissues. This progress also allows us to present the first... (More)
The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time-of-flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in the human prostate. For the first time, we demonstrate Monte Carlo-based evaluation of in vivo TOF photon migration data. We show that this approach is crucial in order to avoid the large errors associated with the use of time-resolved diffusion theory of light propagation in prostate-like tissues. This progress also allows us to present the first in vivo scattering spectroscopy of human prostate tissue. Furthermore, TOF spectroscopy. in contrast to the more common steady-state approach, is insensitive to bleedings, and has been found highly reliable (100% success rate). (C) 2008 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Optical Properties, Time-resolved Spectroscopy, Photon Migration, Tissue Oxygenation, Human Prostate, Hemoglobin, Monte Carlo, White
in
Journal of Biophotonics
volume
1
issue
3
pages
200 - 203
publisher
John Wiley & Sons
external identifiers
  • wos:000261740300014
  • scopus:67149145255
ISSN
1864-063X
DOI
10.1002/jbio.200710025
language
English
LU publication?
yes
id
1364d390-8872-454f-a159-6d12d831b131 (old id 1383820)
date added to LUP
2009-04-24 08:40:28
date last changed
2017-02-05 03:31:35
@article{1364d390-8872-454f-a159-6d12d831b131,
  abstract     = {The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time-of-flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in the human prostate. For the first time, we demonstrate Monte Carlo-based evaluation of in vivo TOF photon migration data. We show that this approach is crucial in order to avoid the large errors associated with the use of time-resolved diffusion theory of light propagation in prostate-like tissues. This progress also allows us to present the first in vivo scattering spectroscopy of human prostate tissue. Furthermore, TOF spectroscopy. in contrast to the more common steady-state approach, is insensitive to bleedings, and has been found highly reliable (100% success rate). (C) 2008 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim},
  author       = {Svensson, Tomas and Alerstam, Erik and Einarsdottir, Margret and Svanberg, Katarina and Andersson-Engels, Stefan},
  issn         = {1864-063X},
  keyword      = {Optical Properties,Time-resolved Spectroscopy,Photon Migration,Tissue Oxygenation,Human Prostate,Hemoglobin,Monte Carlo,White},
  language     = {eng},
  number       = {3},
  pages        = {200--203},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biophotonics},
  title        = {Towards accurate in vivo spectroscopy of the human prostate},
  url          = {http://dx.doi.org/10.1002/jbio.200710025},
  volume       = {1},
  year         = {2008},
}