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Simulation of the release from a multiparticulate system validated by single pellet and dose release experiments

Borgquist, Per LU ; Nevsten, Pernilla LU ; Nilsson, Bernt LU ; Wallenberg, Reine LU and Axelsson, Anders LU (2004) In Journal of Controlled Release 97(3). p.453-465
Abstract
A previously described single-pellet release model has been simplified and modified to give predictions of the release from multiple-pellet systems, besides describing the release from single pellets. The simplified single-pellet model has been verified using single-pellet data and has been used to estimate three release-controlling parameters, namely the pellet core radius, the overall mass transfer coefficient, and the lag time. Single-pellet release experiments showed that the release from the individual film-coated drug cores resulted in a wide distribution of release profiles, a phenomenon not observed on the dose level. Therefore, the parameter estimations resulted in distributions of these parameter values. The core radius and the... (More)
A previously described single-pellet release model has been simplified and modified to give predictions of the release from multiple-pellet systems, besides describing the release from single pellets. The simplified single-pellet model has been verified using single-pellet data and has been used to estimate three release-controlling parameters, namely the pellet core radius, the overall mass transfer coefficient, and the lag time. Single-pellet release experiments showed that the release from the individual film-coated drug cores resulted in a wide distribution of release profiles, a phenomenon not observed on the dose level. Therefore, the parameter estimations resulted in distributions of these parameter values. The core radius and the lag times compared well with the experimental data. The distributions were used as input data for the multiple pellet model, in order to predict the release profiles on the dose level, showing results consistent with the measured dose release. The dose-predictive ability of the model was demonstrated in simulations by studying the effect of a change in the size of the single subunits (of constant total dose), showing that smaller pellets give an increased release rate with less variation. The model for predicting dose-release profiles could be of great value in optimising the performance of an existing formulation, as well as in the development of a new control led-release pharmaceutical. (C) 2004 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Controlled Release
volume
97
issue
3
pages
453 - 465
publisher
Elsevier
external identifiers
  • pmid:15212877
  • wos:000222531500006
  • scopus:3042690833
ISSN
1873-4995
DOI
10.1016/j.jconrel.2004.03.024
language
English
LU publication?
yes
id
9389c008-a34e-434c-b8d7-154647fe7a5b (old id 138819)
date added to LUP
2007-06-25 10:30:29
date last changed
2017-09-03 03:41:32
@article{9389c008-a34e-434c-b8d7-154647fe7a5b,
  abstract     = {A previously described single-pellet release model has been simplified and modified to give predictions of the release from multiple-pellet systems, besides describing the release from single pellets. The simplified single-pellet model has been verified using single-pellet data and has been used to estimate three release-controlling parameters, namely the pellet core radius, the overall mass transfer coefficient, and the lag time. Single-pellet release experiments showed that the release from the individual film-coated drug cores resulted in a wide distribution of release profiles, a phenomenon not observed on the dose level. Therefore, the parameter estimations resulted in distributions of these parameter values. The core radius and the lag times compared well with the experimental data. The distributions were used as input data for the multiple pellet model, in order to predict the release profiles on the dose level, showing results consistent with the measured dose release. The dose-predictive ability of the model was demonstrated in simulations by studying the effect of a change in the size of the single subunits (of constant total dose), showing that smaller pellets give an increased release rate with less variation. The model for predicting dose-release profiles could be of great value in optimising the performance of an existing formulation, as well as in the development of a new control led-release pharmaceutical. (C) 2004 Elsevier B.V. All rights reserved.},
  author       = {Borgquist, Per and Nevsten, Pernilla and Nilsson, Bernt and Wallenberg, Reine and Axelsson, Anders},
  issn         = {1873-4995},
  language     = {eng},
  number       = {3},
  pages        = {453--465},
  publisher    = {Elsevier},
  series       = {Journal of Controlled Release},
  title        = {Simulation of the release from a multiparticulate system validated by single pellet and dose release experiments},
  url          = {http://dx.doi.org/10.1016/j.jconrel.2004.03.024},
  volume       = {97},
  year         = {2004},
}