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Absolute quantification of cerebral blood flow in neurologically normal volunteers: Dynamic-susceptibility contrast MRI-perfusion compared with computed tomography (CT)-perfusion

Doerthe, Ziegelitz; Göran, Starck; Irene, Mikkelsen; Mats, Tullberg; Mikael, Edsbagge; Carsten, Wikkelsö; Eva, Forsell-Aronsson; Holtås, Stig LU and Knutsson, Linda LU (2009) In Magnetic Resonance in Medicine 62(1). p.56-65
Abstract
To improve the reproducibility of arterial input function (AIF) registration and absolute cerebral blood flow (CBF) quantification in dynamic-susceptibility MRI-perfusion (MRP) at 1.5T, we rescaled the AIF by use of a venous output function (VOF). We compared CBF estimates of 20 healthy, elderly volunteers, obtained by computed tomography (CT)-perfusion (CTP) and MRP on two consecutive days. MRP, calculated without the AIF correction, did not result in any significant correlation with CTP. The rescaled MRP showed fair to moderate correlation with CTP for the central gray matter (GM) and the whole brain. Our results indicate that the method used for correction of partial volume effects (PVEs) improves MRP experiments by reducing... (More)
To improve the reproducibility of arterial input function (AIF) registration and absolute cerebral blood flow (CBF) quantification in dynamic-susceptibility MRI-perfusion (MRP) at 1.5T, we rescaled the AIF by use of a venous output function (VOF). We compared CBF estimates of 20 healthy, elderly volunteers, obtained by computed tomography (CT)-perfusion (CTP) and MRP on two consecutive days. MRP, calculated without the AIF correction, did not result in any significant correlation with CTP. The rescaled MRP showed fair to moderate correlation with CTP for the central gray matter (GM) and the whole brain. Our results indicate that the method used for correction of partial volume effects (PVEs) improves MRP experiments by reducing AIF-introduced variance at 1.5T. Magn Reson Med, 2009. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Magnetic Resonance in Medicine
volume
62
issue
1
pages
56 - 65
publisher
Wiley Online Library
external identifiers
  • wos:000267404300007
  • scopus:67650033400
ISSN
1522-2594
DOI
10.1002/mrm.21975
language
English
LU publication?
yes
id
686ebb13-4abe-4e63-9ca3-52f623d68783 (old id 1397613)
date added to LUP
2009-08-31 10:43:13
date last changed
2017-01-01 05:05:21
@article{686ebb13-4abe-4e63-9ca3-52f623d68783,
  abstract     = {To improve the reproducibility of arterial input function (AIF) registration and absolute cerebral blood flow (CBF) quantification in dynamic-susceptibility MRI-perfusion (MRP) at 1.5T, we rescaled the AIF by use of a venous output function (VOF). We compared CBF estimates of 20 healthy, elderly volunteers, obtained by computed tomography (CT)-perfusion (CTP) and MRP on two consecutive days. MRP, calculated without the AIF correction, did not result in any significant correlation with CTP. The rescaled MRP showed fair to moderate correlation with CTP for the central gray matter (GM) and the whole brain. Our results indicate that the method used for correction of partial volume effects (PVEs) improves MRP experiments by reducing AIF-introduced variance at 1.5T. Magn Reson Med, 2009.},
  author       = {Doerthe, Ziegelitz and Göran, Starck and Irene, Mikkelsen and Mats, Tullberg and Mikael, Edsbagge and Carsten, Wikkelsö and Eva, Forsell-Aronsson and Holtås, Stig and Knutsson, Linda},
  issn         = {1522-2594},
  language     = {eng},
  number       = {1},
  pages        = {56--65},
  publisher    = {Wiley Online Library},
  series       = {Magnetic Resonance in Medicine},
  title        = {Absolute quantification of cerebral blood flow in neurologically normal volunteers: Dynamic-susceptibility contrast MRI-perfusion compared with computed tomography (CT)-perfusion},
  url          = {http://dx.doi.org/10.1002/mrm.21975},
  volume       = {62},
  year         = {2009},
}