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Health-Related Quality of Life of Patients Receiving Low-toxicity Immunosuppressive Regimens:. A Substudy of the Symphony Study

Oppenheimer, Federico; Rebollo, Pablo; Grinyo, Josep M.; Ortega, Francisco; Sanchez-Plumed, Jaime; Gonzalez-Molina, Miguel; Hernandez, Domingo; Anaya, Fernando and Ekberg, Henrik LU (2009) In Transplantation 87(8). p.1210-1213
Abstract
Objective. To evaluate health-related quality of life (HRQoL) in patients with different low-toxicity regimens post-transplantation. Methods. One hundred fifty-six patients were randomized to standard-dose cyclosporine A (CsA), mycophenolate mofetil, and corticosteroids or daclizumab induction, mycophenolate mofetil, and corticosteroids with a low dose of CsA, tacrolimus (Low-Tac), or sirolimus. SF-36 Health survey was completed at baseline, 3, 6, and 12 months. Results. There were no differences between groups in SF-36 at baseline or at month 12. Low-Tac showed higher scores at month 3 than standard-dose CsA and low dose of CsA. Patients with serum creatinine less than or equal to 1.5 mg/mL had better HRQoL at 6 and 12 months. Proportion... (More)
Objective. To evaluate health-related quality of life (HRQoL) in patients with different low-toxicity regimens post-transplantation. Methods. One hundred fifty-six patients were randomized to standard-dose cyclosporine A (CsA), mycophenolate mofetil, and corticosteroids or daclizumab induction, mycophenolate mofetil, and corticosteroids with a low dose of CsA, tacrolimus (Low-Tac), or sirolimus. SF-36 Health survey was completed at baseline, 3, 6, and 12 months. Results. There were no differences between groups in SF-36 at baseline or at month 12. Low-Tac showed higher scores at month 3 than standard-dose CsA and low dose of CsA. Patients with serum creatinine less than or equal to 1.5 mg/mL had better HRQoL at 6 and 12 months. Proportion of these patients was higher in Low-Tac at 6 months. Physical component summary of Patients increased during follow-up, but mental component summary did not. Patients with acute rejection showed lower mental component summary at 6 months. Conclusions. No HRQoL differences were identified among groups, but the low-dose Tac group showed the fastest improvement. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Health-related quality of life, Kidney transplant, Immunosuppression
in
Transplantation
volume
87
issue
8
pages
1210 - 1213
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000265461600016
  • scopus:65549169951
ISSN
1534-6080
DOI
10.1097/TP.0b013e31819ec41f
language
English
LU publication?
yes
id
abbed14f-7aa1-4277-ab38-8ba9c2b93978 (old id 1399388)
date added to LUP
2009-06-15 15:30:51
date last changed
2017-07-30 04:13:00
@article{abbed14f-7aa1-4277-ab38-8ba9c2b93978,
  abstract     = {Objective. To evaluate health-related quality of life (HRQoL) in patients with different low-toxicity regimens post-transplantation. Methods. One hundred fifty-six patients were randomized to standard-dose cyclosporine A (CsA), mycophenolate mofetil, and corticosteroids or daclizumab induction, mycophenolate mofetil, and corticosteroids with a low dose of CsA, tacrolimus (Low-Tac), or sirolimus. SF-36 Health survey was completed at baseline, 3, 6, and 12 months. Results. There were no differences between groups in SF-36 at baseline or at month 12. Low-Tac showed higher scores at month 3 than standard-dose CsA and low dose of CsA. Patients with serum creatinine less than or equal to 1.5 mg/mL had better HRQoL at 6 and 12 months. Proportion of these patients was higher in Low-Tac at 6 months. Physical component summary of Patients increased during follow-up, but mental component summary did not. Patients with acute rejection showed lower mental component summary at 6 months. Conclusions. No HRQoL differences were identified among groups, but the low-dose Tac group showed the fastest improvement.},
  author       = {Oppenheimer, Federico and Rebollo, Pablo and Grinyo, Josep M. and Ortega, Francisco and Sanchez-Plumed, Jaime and Gonzalez-Molina, Miguel and Hernandez, Domingo and Anaya, Fernando and Ekberg, Henrik},
  issn         = {1534-6080},
  keyword      = {Health-related quality of life,Kidney transplant,Immunosuppression},
  language     = {eng},
  number       = {8},
  pages        = {1210--1213},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Transplantation},
  title        = {Health-Related Quality of Life of Patients Receiving Low-toxicity Immunosuppressive Regimens:. A Substudy of the Symphony Study},
  url          = {http://dx.doi.org/10.1097/TP.0b013e31819ec41f},
  volume       = {87},
  year         = {2009},
}