Health-Related Quality of Life of Patients Receiving Low-toxicity Immunosuppressive Regimens:. A Substudy of the Symphony Study
(2009) In Transplantation 87(8). p.1210-1213- Abstract
- Objective. To evaluate health-related quality of life (HRQoL) in patients with different low-toxicity regimens post-transplantation. Methods. One hundred fifty-six patients were randomized to standard-dose cyclosporine A (CsA), mycophenolate mofetil, and corticosteroids or daclizumab induction, mycophenolate mofetil, and corticosteroids with a low dose of CsA, tacrolimus (Low-Tac), or sirolimus. SF-36 Health survey was completed at baseline, 3, 6, and 12 months. Results. There were no differences between groups in SF-36 at baseline or at month 12. Low-Tac showed higher scores at month 3 than standard-dose CsA and low dose of CsA. Patients with serum creatinine less than or equal to 1.5 mg/mL had better HRQoL at 6 and 12 months. Proportion... (More)
- Objective. To evaluate health-related quality of life (HRQoL) in patients with different low-toxicity regimens post-transplantation. Methods. One hundred fifty-six patients were randomized to standard-dose cyclosporine A (CsA), mycophenolate mofetil, and corticosteroids or daclizumab induction, mycophenolate mofetil, and corticosteroids with a low dose of CsA, tacrolimus (Low-Tac), or sirolimus. SF-36 Health survey was completed at baseline, 3, 6, and 12 months. Results. There were no differences between groups in SF-36 at baseline or at month 12. Low-Tac showed higher scores at month 3 than standard-dose CsA and low dose of CsA. Patients with serum creatinine less than or equal to 1.5 mg/mL had better HRQoL at 6 and 12 months. Proportion of these patients was higher in Low-Tac at 6 months. Physical component summary of Patients increased during follow-up, but mental component summary did not. Patients with acute rejection showed lower mental component summary at 6 months. Conclusions. No HRQoL differences were identified among groups, but the low-dose Tac group showed the fastest improvement. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1399388
- author
- Oppenheimer, Federico ; Rebollo, Pablo ; Grinyo, Josep M. ; Ortega, Francisco ; Sanchez-Plumed, Jaime ; Gonzalez-Molina, Miguel ; Hernandez, Domingo ; Anaya, Fernando and Ekberg, Henrik LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Health-related quality of life, Kidney transplant, Immunosuppression
- in
- Transplantation
- volume
- 87
- issue
- 8
- pages
- 1210 - 1213
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000265461600016
- scopus:65549169951
- pmid:19384168
- ISSN
- 1534-6080
- DOI
- 10.1097/TP.0b013e31819ec41f
- language
- English
- LU publication?
- yes
- id
- abbed14f-7aa1-4277-ab38-8ba9c2b93978 (old id 1399388)
- date added to LUP
- 2016-04-01 14:08:48
- date last changed
- 2022-01-27 23:01:18
@article{abbed14f-7aa1-4277-ab38-8ba9c2b93978, abstract = {{Objective. To evaluate health-related quality of life (HRQoL) in patients with different low-toxicity regimens post-transplantation. Methods. One hundred fifty-six patients were randomized to standard-dose cyclosporine A (CsA), mycophenolate mofetil, and corticosteroids or daclizumab induction, mycophenolate mofetil, and corticosteroids with a low dose of CsA, tacrolimus (Low-Tac), or sirolimus. SF-36 Health survey was completed at baseline, 3, 6, and 12 months. Results. There were no differences between groups in SF-36 at baseline or at month 12. Low-Tac showed higher scores at month 3 than standard-dose CsA and low dose of CsA. Patients with serum creatinine less than or equal to 1.5 mg/mL had better HRQoL at 6 and 12 months. Proportion of these patients was higher in Low-Tac at 6 months. Physical component summary of Patients increased during follow-up, but mental component summary did not. Patients with acute rejection showed lower mental component summary at 6 months. Conclusions. No HRQoL differences were identified among groups, but the low-dose Tac group showed the fastest improvement.}}, author = {{Oppenheimer, Federico and Rebollo, Pablo and Grinyo, Josep M. and Ortega, Francisco and Sanchez-Plumed, Jaime and Gonzalez-Molina, Miguel and Hernandez, Domingo and Anaya, Fernando and Ekberg, Henrik}}, issn = {{1534-6080}}, keywords = {{Health-related quality of life; Kidney transplant; Immunosuppression}}, language = {{eng}}, number = {{8}}, pages = {{1210--1213}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Transplantation}}, title = {{Health-Related Quality of Life of Patients Receiving Low-toxicity Immunosuppressive Regimens:. A Substudy of the Symphony Study}}, url = {{http://dx.doi.org/10.1097/TP.0b013e31819ec41f}}, doi = {{10.1097/TP.0b013e31819ec41f}}, volume = {{87}}, year = {{2009}}, }