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Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction

Llona-Minguez, Sabin; Throup, Adam; Steiner, Emilie; Lightowler, Molly; Van der Haegen, Sandra; Homan, Evert; Eriksson, Lars; Stenmark, Pål LU ; Jenmalm-Jensen, Annika and Helleday, Thomas (2017) In Organic and Biomolecular Chemistry 15(37). p.7758-7764
Abstract

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.

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author
publishing date
type
Contribution to journal
publication status
published
in
Organic and Biomolecular Chemistry
volume
15
issue
37
pages
7758 - 7764
publisher
Royal Society of Chemistry
ISSN
1477-0539
DOI
10.1039/c7ob02069d
language
English
LU publication?
no
id
13f6ae0c-483a-4624-8a59-aa735f7c2dd5
date added to LUP
2019-04-30 07:54:13
date last changed
2019-07-31 04:00:55
@article{13f6ae0c-483a-4624-8a59-aa735f7c2dd5,
  abstract     = {<p>Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels-Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.</p>},
  author       = {Llona-Minguez, Sabin and Throup, Adam and Steiner, Emilie and Lightowler, Molly and Van der Haegen, Sandra and Homan, Evert and Eriksson, Lars and Stenmark, Pål and Jenmalm-Jensen, Annika and Helleday, Thomas},
  issn         = {1477-0539},
  language     = {eng},
  month        = {09},
  number       = {37},
  pages        = {7758--7764},
  publisher    = {Royal Society of Chemistry},
  series       = {Organic and Biomolecular Chemistry},
  title        = {Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction},
  url          = {http://dx.doi.org/10.1039/c7ob02069d},
  volume       = {15},
  year         = {2017},
}