Advanced

Does gold concentration in the blood influence the result of patch testing to gold?

Ekqvist, Susanne LU ; Lundh, Thomas LU ; Svedman, Cecilia LU ; Björk, Jonas LU ; Möller, Halvor LU ; Nilsson, L.A.F. and Bruze, Magnus LU (2009) In British Journal of Dermatology 160(5). p.1016-1021
Abstract
We have recently found a correlation between contact allergy to gold sodium thiosulphate (GSTS) and gold concentration in the blood (B-Au) in a stented population: the higher the B-Au, the stronger the patch-test reaction. To further investigate the correlation between B-Au and patch-test reactivity to gold. In this provocation control cross-over trial of 24 patients with dermatitis with a known contact allergy to gold, the patients were randomized into two groups where one was topically provoked to gold (15 mg GSTS) and one to the control. All patients were simultaneously patch tested with GSTS in 10 aqueous dilutions (1.1 mg GSTS). Patch-test readings were performed and blood was drawn. After 6 weeks, the experiment was repeated and the... (More)
We have recently found a correlation between contact allergy to gold sodium thiosulphate (GSTS) and gold concentration in the blood (B-Au) in a stented population: the higher the B-Au, the stronger the patch-test reaction. To further investigate the correlation between B-Au and patch-test reactivity to gold. In this provocation control cross-over trial of 24 patients with dermatitis with a known contact allergy to gold, the patients were randomized into two groups where one was topically provoked to gold (15 mg GSTS) and one to the control. All patients were simultaneously patch tested with GSTS in 10 aqueous dilutions (1.1 mg GSTS). Patch-test readings were performed and blood was drawn. After 6 weeks, the experiment was repeated and the group that had previously been provoked with gold was now provoked with the control and vice versa. B-Au was higher after gold provocation whereas no treatment effect was discerned for minimal eliciting concentration (MEC) or summarized test score (STS). Instead, significant differences in period effect were observed implying higher B-Au and STS and lower MEC on test occasion II. The most likely explanation is the increased B-Au and/or booster effect from test occasion I. There was a correlation between B-Au and MEC: the higher the B-Au, the lower the MEC. The correlation between B-Au and MEC indicates that the B-Au is of importance for the skin reactivity to gold. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gold concentration in blood, contact allergy, gold, patch-test, reactivity
in
British Journal of Dermatology
volume
160
issue
5
pages
1016 - 1021
publisher
Wiley-Blackwell
external identifiers
  • wos:000265185500013
  • pmid:19434784
  • scopus:64849113698
ISSN
1365-2133
DOI
10.1111/j.1365-2133.2009.09065.x
language
English
LU publication?
yes
id
33b81dac-d4a5-4754-ba22-f255de1d715a (old id 1400371)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19434784?dopt=Abstract
date added to LUP
2009-06-15 14:11:52
date last changed
2017-04-30 07:05:47
@article{33b81dac-d4a5-4754-ba22-f255de1d715a,
  abstract     = {We have recently found a correlation between contact allergy to gold sodium thiosulphate (GSTS) and gold concentration in the blood (B-Au) in a stented population: the higher the B-Au, the stronger the patch-test reaction. To further investigate the correlation between B-Au and patch-test reactivity to gold. In this provocation control cross-over trial of 24 patients with dermatitis with a known contact allergy to gold, the patients were randomized into two groups where one was topically provoked to gold (15 mg GSTS) and one to the control. All patients were simultaneously patch tested with GSTS in 10 aqueous dilutions (1.1 mg GSTS). Patch-test readings were performed and blood was drawn. After 6 weeks, the experiment was repeated and the group that had previously been provoked with gold was now provoked with the control and vice versa. B-Au was higher after gold provocation whereas no treatment effect was discerned for minimal eliciting concentration (MEC) or summarized test score (STS). Instead, significant differences in period effect were observed implying higher B-Au and STS and lower MEC on test occasion II. The most likely explanation is the increased B-Au and/or booster effect from test occasion I. There was a correlation between B-Au and MEC: the higher the B-Au, the lower the MEC. The correlation between B-Au and MEC indicates that the B-Au is of importance for the skin reactivity to gold.},
  author       = {Ekqvist, Susanne and Lundh, Thomas and Svedman, Cecilia and Björk, Jonas and Möller, Halvor and Nilsson, L.A.F. and Bruze, Magnus},
  issn         = {1365-2133},
  keyword      = {gold concentration in blood,contact allergy,gold,patch-test,reactivity},
  language     = {eng},
  number       = {5},
  pages        = {1016--1021},
  publisher    = {Wiley-Blackwell},
  series       = {British Journal of Dermatology},
  title        = {Does gold concentration in the blood influence the result of patch testing to gold?},
  url          = {http://dx.doi.org/10.1111/j.1365-2133.2009.09065.x},
  volume       = {160},
  year         = {2009},
}