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CD-sens: a biological measure of immunological changes stimulated by ASIT

Nopp, A.; Cardell, Lars-Olaf LU ; Johansson, S. G. O. and Oman, H. (2009) In Allergy 64(5). p.811-814
Abstract
Allergen-specific immunotherapy (ASIT) in allergic rhinitis and asthma is the only treatment that effects the long-term development of these diseases. Basophil allergen threshold sensitivity, CD-sens, which is a valuable complement to resource-demanding clinical challenge tests, was used to monitor the initiation of ASIT induced allergen 'blocking activity'. Patients IgE-sensitized to timothy (n = 14) or birch (n = 19) pollen were started on conventional (8-16 weeks) or ultra rush ASIT, respectively, and followed by measurements of CD-sens, allergen binding activity (ABA) and serum IgG4- and IgE-antibody concentrations. CD-sens decreased during the early phase of ASIT-treatment. In parallel, ABA increased and correlated significantly with... (More)
Allergen-specific immunotherapy (ASIT) in allergic rhinitis and asthma is the only treatment that effects the long-term development of these diseases. Basophil allergen threshold sensitivity, CD-sens, which is a valuable complement to resource-demanding clinical challenge tests, was used to monitor the initiation of ASIT induced allergen 'blocking activity'. Patients IgE-sensitized to timothy (n = 14) or birch (n = 19) pollen were started on conventional (8-16 weeks) or ultra rush ASIT, respectively, and followed by measurements of CD-sens, allergen binding activity (ABA) and serum IgG4- and IgE-antibody concentrations. CD-sens decreased during the early phase of ASIT-treatment. In parallel, ABA increased and correlated significantly with the increasing levels of IgG4 antibody concentrations. High dosages of allergen were more effective while mode of dosing up did not seem to matter. No change was seen in basophil reactivity. CD-sens and ABA, in contrast to basophil reactivity, seem to be promising tools to monitor protective immune responses initiated by ASIT. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IgE, basophil, FACS, immunotherapy
in
Allergy
volume
64
issue
5
pages
811 - 814
publisher
Wiley-Blackwell
external identifiers
  • wos:000264823200019
  • scopus:63849135938
ISSN
1398-9995
DOI
10.1111/j.1398-9995.2008.01900.x
language
English
LU publication?
yes
id
75b12f54-9ab9-4dc4-a93c-f11b85db6118 (old id 1400789)
date added to LUP
2009-06-15 12:52:13
date last changed
2017-07-23 04:10:54
@article{75b12f54-9ab9-4dc4-a93c-f11b85db6118,
  abstract     = {Allergen-specific immunotherapy (ASIT) in allergic rhinitis and asthma is the only treatment that effects the long-term development of these diseases. Basophil allergen threshold sensitivity, CD-sens, which is a valuable complement to resource-demanding clinical challenge tests, was used to monitor the initiation of ASIT induced allergen 'blocking activity'. Patients IgE-sensitized to timothy (n = 14) or birch (n = 19) pollen were started on conventional (8-16 weeks) or ultra rush ASIT, respectively, and followed by measurements of CD-sens, allergen binding activity (ABA) and serum IgG4- and IgE-antibody concentrations. CD-sens decreased during the early phase of ASIT-treatment. In parallel, ABA increased and correlated significantly with the increasing levels of IgG4 antibody concentrations. High dosages of allergen were more effective while mode of dosing up did not seem to matter. No change was seen in basophil reactivity. CD-sens and ABA, in contrast to basophil reactivity, seem to be promising tools to monitor protective immune responses initiated by ASIT.},
  author       = {Nopp, A. and Cardell, Lars-Olaf and Johansson, S. G. O. and Oman, H.},
  issn         = {1398-9995},
  keyword      = {IgE,basophil,FACS,immunotherapy},
  language     = {eng},
  number       = {5},
  pages        = {811--814},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {CD-sens: a biological measure of immunological changes stimulated by ASIT},
  url          = {http://dx.doi.org/10.1111/j.1398-9995.2008.01900.x},
  volume       = {64},
  year         = {2009},
}