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Penile cancer: epidemiology, pathogenesis and prevention

Bleeker, M. C. G.; Heideman, D. A. M.; Snijders, P. J. F.; Horenblas, S.; Dillner, Joakim LU and Meijer, C. J. L. M. (2009) In World Journal of Urology 27(2). p.141-150
Abstract
Penile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare, but the highest in some developing countries. Insight into its precursor lesions, pathogenesis and risk factors offers options to prevent this potentially mutilating disease. This review presents an overview of the different histologically and clinically identified precursor lesions of penile cancer and discusses the molecular pathogenesis, including the role of HPV in penile cancer development. A systematic review of the literature evaluating penile carcinogenesis, risk factors and molecular mechanisms involved. Careful monitoring of men with lichen sclerosis, genital Bowen's disease, erythroplasia of Queyrat and bowenoid papulosis seems... (More)
Penile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare, but the highest in some developing countries. Insight into its precursor lesions, pathogenesis and risk factors offers options to prevent this potentially mutilating disease. This review presents an overview of the different histologically and clinically identified precursor lesions of penile cancer and discusses the molecular pathogenesis, including the role of HPV in penile cancer development. A systematic review of the literature evaluating penile carcinogenesis, risk factors and molecular mechanisms involved. Careful monitoring of men with lichen sclerosis, genital Bowen's disease, erythroplasia of Queyrat and bowenoid papulosis seems useful, thereby offering early recognition of penile cancer and, subsequently, conservative therapeutic options. Special attention is given to flat penile lesions, which contain high numbers of HPV. Their role in HPV transmission to sexual partners is highlighted, but their potential to transform as a precursor lesion into penile cancer has been unsatisfactorily explored. Further research should not only focus on HPV mediated pathogenic pathways but also on the non-HPV related molecular and genetic factors that play a role in penile cancer development. Options for prevention of penile cancer include (neonatal) circumcision, limitation of penile HPV infections (either by prophylactic vaccination or condom use), prevention of phimosis, treatment of chronic inflammatory conditions, limiting PUVA treatment, smoking cessation and hygienic measures. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lesions, Flat penile, Lichen sclerosis, Erythroplasia of Queyrat, disease, Genital Bowen's, Penile cancer, Penile intraepithelial neoplasia, Prevention, Molecular pathogenesis, Human papillomavirus
in
World Journal of Urology
volume
27
issue
2
pages
141 - 150
publisher
Springer
external identifiers
  • wos:000264551100002
  • scopus:63649084378
ISSN
1433-8726
DOI
10.1007/s00345-008-0302-z
language
English
LU publication?
yes
id
070410ae-8e18-4561-8858-010140f8f5cd (old id 1401288)
date added to LUP
2009-06-15 11:16:24
date last changed
2017-12-10 04:23:54
@article{070410ae-8e18-4561-8858-010140f8f5cd,
  abstract     = {Penile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare, but the highest in some developing countries. Insight into its precursor lesions, pathogenesis and risk factors offers options to prevent this potentially mutilating disease. This review presents an overview of the different histologically and clinically identified precursor lesions of penile cancer and discusses the molecular pathogenesis, including the role of HPV in penile cancer development. A systematic review of the literature evaluating penile carcinogenesis, risk factors and molecular mechanisms involved. Careful monitoring of men with lichen sclerosis, genital Bowen's disease, erythroplasia of Queyrat and bowenoid papulosis seems useful, thereby offering early recognition of penile cancer and, subsequently, conservative therapeutic options. Special attention is given to flat penile lesions, which contain high numbers of HPV. Their role in HPV transmission to sexual partners is highlighted, but their potential to transform as a precursor lesion into penile cancer has been unsatisfactorily explored. Further research should not only focus on HPV mediated pathogenic pathways but also on the non-HPV related molecular and genetic factors that play a role in penile cancer development. Options for prevention of penile cancer include (neonatal) circumcision, limitation of penile HPV infections (either by prophylactic vaccination or condom use), prevention of phimosis, treatment of chronic inflammatory conditions, limiting PUVA treatment, smoking cessation and hygienic measures.},
  author       = {Bleeker, M. C. G. and Heideman, D. A. M. and Snijders, P. J. F. and Horenblas, S. and Dillner, Joakim and Meijer, C. J. L. M.},
  issn         = {1433-8726},
  keyword      = {lesions,Flat penile,Lichen sclerosis,Erythroplasia of Queyrat,disease,Genital Bowen's,Penile cancer,Penile intraepithelial neoplasia,Prevention,Molecular pathogenesis,Human papillomavirus},
  language     = {eng},
  number       = {2},
  pages        = {141--150},
  publisher    = {Springer},
  series       = {World Journal of Urology},
  title        = {Penile cancer: epidemiology, pathogenesis and prevention},
  url          = {http://dx.doi.org/10.1007/s00345-008-0302-z},
  volume       = {27},
  year         = {2009},
}