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Surveillance of Vaccine Safety: Comparison of parental reports with routine surveillance and a clinical trial

Netterlid, Eva LU ; Edwinson Månsson, Marie LU and Håkansson, Anders LU (2009) In Vaccine 27(14). p.2042-2047
Abstract
One way to maintain confidence in vaccination programmes is to improve monitoring of immunisation safety. We studied active parental reporting of adverse events after a booster dose of diphtheria-tetanus toxoid (DT). 7193 children received the vaccine. Questionnaires were submitted by 84.2% of the parents, who reported reactions for 9.2% of the children. Four percent of events were classified as moderate/severe by interviews. Relative risk of redness and swelling reported was 0.24 (95% CI. 0.13-0.42) compared to a clinical trial, while it was 71.0 (44-114) compared to passive surveillance. Active surveillance by parental reports is a useful complement to passive surveillance of childhood immunisations to generate hypotheses for evaluation... (More)
One way to maintain confidence in vaccination programmes is to improve monitoring of immunisation safety. We studied active parental reporting of adverse events after a booster dose of diphtheria-tetanus toxoid (DT). 7193 children received the vaccine. Questionnaires were submitted by 84.2% of the parents, who reported reactions for 9.2% of the children. Four percent of events were classified as moderate/severe by interviews. Relative risk of redness and swelling reported was 0.24 (95% CI. 0.13-0.42) compared to a clinical trial, while it was 71.0 (44-114) compared to passive surveillance. Active surveillance by parental reports is a useful complement to passive surveillance of childhood immunisations to generate hypotheses for evaluation in controlled studies. (C) 2009 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Local reactions, Vaccine safety, Parental reports
in
Vaccine
volume
27
issue
14
pages
2042 - 2047
publisher
Elsevier
external identifiers
  • wos:000264680700009
  • scopus:61549086525
ISSN
1873-2518
DOI
10.1016/j.vaccine.2009.01.131
language
English
LU publication?
yes
id
fc8de849-b9a8-491d-8dce-4bf518305f7a (old id 1401296)
date added to LUP
2009-06-15 11:17:09
date last changed
2017-05-14 03:38:11
@article{fc8de849-b9a8-491d-8dce-4bf518305f7a,
  abstract     = {One way to maintain confidence in vaccination programmes is to improve monitoring of immunisation safety. We studied active parental reporting of adverse events after a booster dose of diphtheria-tetanus toxoid (DT). 7193 children received the vaccine. Questionnaires were submitted by 84.2% of the parents, who reported reactions for 9.2% of the children. Four percent of events were classified as moderate/severe by interviews. Relative risk of redness and swelling reported was 0.24 (95% CI. 0.13-0.42) compared to a clinical trial, while it was 71.0 (44-114) compared to passive surveillance. Active surveillance by parental reports is a useful complement to passive surveillance of childhood immunisations to generate hypotheses for evaluation in controlled studies. (C) 2009 Elsevier Ltd. All rights reserved.},
  author       = {Netterlid, Eva and Edwinson Månsson, Marie and Håkansson, Anders},
  issn         = {1873-2518},
  keyword      = {Local reactions,Vaccine safety,Parental reports},
  language     = {eng},
  number       = {14},
  pages        = {2042--2047},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Surveillance of Vaccine Safety: Comparison of parental reports with routine surveillance and a clinical trial},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2009.01.131},
  volume       = {27},
  year         = {2009},
}