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Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Vrieling, Alina; Verhage, Bas A. J.; van Duijnhoven, Franzel J. B.; Jenab, Mazda; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Clavel-Chapelon, Francoise; Boutron-Ruault, Marie-Christine and Kaaks, Rudolf, et al. (2009) In International Journal of Cancer 124(8). p.1926-1934
Abstract
Many case-control studies have suggested that higher consumption of fruit and vegetables is associated with a lower risk or pancreatic cancer, whereas cohort studies do not support such an association. We examined the associations of the consumption of. fruits and vegetables and their main subgroups with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is comprised of over 520,000 Subjects recruited from 10 European countries. The present study included 555 exocrine pancreatic cancer cases after an average follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models, stratified by age at recruitment, gender, and study center. and adjusted for total... (More)
Many case-control studies have suggested that higher consumption of fruit and vegetables is associated with a lower risk or pancreatic cancer, whereas cohort studies do not support such an association. We examined the associations of the consumption of. fruits and vegetables and their main subgroups with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is comprised of over 520,000 Subjects recruited from 10 European countries. The present study included 555 exocrine pancreatic cancer cases after an average follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models, stratified by age at recruitment, gender, and study center. and adjusted for total energy intake, weight, height, history of diabetes mellitus, and smoking status. Total consumption of fruit and vegetables, combined or separately, as well as subgroups of vegetables and fruits were unrelated to risk of pancreatic cancer. Hazard ratios (95% CI) for the highest versus the lowest quartile were 0.92 (0.68-1.25) for total fruit and vegetables combined, 0.99 (0.73-1.33) for total vegetables, and 1.02 (0.77-1.36) for total fruits. Stratification by gender or smoking status, restriction to microscopically verified cases, and exclusion of the first 2 years of follow-up (lid not materially change the results. These results from a large European prospective cohort Suggest that higher consumption of fruit and vegetables is not associated with decreased risk of pancreatic cancer. (C) 2008 Wiley-Liss, Inc. (Less)
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published
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keywords
vegetables, pancreatic cancer, fruit, EPIC, cohort study
in
International Journal of Cancer
volume
124
issue
8
pages
1926 - 1934
publisher
John Wiley & Sons
external identifiers
  • wos:000264452700023
  • scopus:62449253972
ISSN
0020-7136
DOI
10.1002/ijc.24134
language
English
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yes
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9b7daec2-39da-4589-8323-9b0e93e54449 (old id 1401532)
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2009-06-15 11:00:40
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2017-11-12 03:20:55
@article{9b7daec2-39da-4589-8323-9b0e93e54449,
  abstract     = {Many case-control studies have suggested that higher consumption of fruit and vegetables is associated with a lower risk or pancreatic cancer, whereas cohort studies do not support such an association. We examined the associations of the consumption of. fruits and vegetables and their main subgroups with pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is comprised of over 520,000 Subjects recruited from 10 European countries. The present study included 555 exocrine pancreatic cancer cases after an average follow-up of 8.9 years. Estimates of risk were obtained by Cox proportional hazard models, stratified by age at recruitment, gender, and study center. and adjusted for total energy intake, weight, height, history of diabetes mellitus, and smoking status. Total consumption of fruit and vegetables, combined or separately, as well as subgroups of vegetables and fruits were unrelated to risk of pancreatic cancer. Hazard ratios (95% CI) for the highest versus the lowest quartile were 0.92 (0.68-1.25) for total fruit and vegetables combined, 0.99 (0.73-1.33) for total vegetables, and 1.02 (0.77-1.36) for total fruits. Stratification by gender or smoking status, restriction to microscopically verified cases, and exclusion of the first 2 years of follow-up (lid not materially change the results. These results from a large European prospective cohort Suggest that higher consumption of fruit and vegetables is not associated with decreased risk of pancreatic cancer. (C) 2008 Wiley-Liss, Inc.},
  author       = {Vrieling, Alina and Verhage, Bas A. J. and van Duijnhoven, Franzel J. B. and Jenab, Mazda and Overvad, Kim and Tjonneland, Anne and Olsen, Anja and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Kaaks, Rudolf and Rohrmann, Sabine and Boeing, Heiner and Noethlings, Ute and Trichopoulou, Antonia and John, Tountas and Dimosthenes, Zilis and Palli, Domenico and Sieri, Sabina and Mattielllo, Amalia and Tumino, Rosario and Vineis, Paolo and van Gils, Carla H. and Peeters, Petra H. M. and Engeset, Dagrun and Lund, Eiliv and Rodriguez Suarez, Laudina and Jakszyn, Paula and Larranaga, Nerea and Sanchez, Maria-Jose and Chirlaque, Maria-Dolores and Ardana, Eva and Manjer, Jonas and Lindkvist, Bjoern and Hallmans, Goeran and Ye, Weimin and Bingham, Sheila and Khaw, Kay-Tee and Roddam, Andrew and Key, Tim and Boffetta, Paolo and Duell, Eric J. and Michaud, Dominique S. and Riboli, Elio and Bueno-de-Mesquita, H. Bas},
  issn         = {0020-7136},
  keyword      = {vegetables,pancreatic cancer,fruit,EPIC,cohort study},
  language     = {eng},
  number       = {8},
  pages        = {1926--1934},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.24134},
  volume       = {124},
  year         = {2009},
}