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Developing Saccharomyces cerevisiae strains for second generation bioethanol: Improving xylose fermentation and inhibitor tolerance

Almeida, Joao LU and Hahn-Hägerdal, Bärbel LU (2009) In International Sugar Journal 111(1323). p.172-180
Abstract
The 2nd generation bioethanol will be produced from lignocellulose biomass including agricultural residues such as bagasse, straw, and stover, forest products residues and dedicated energy crops. The bioconversion of lignocellulose raw materials to ethanol requires microorganisms that are able (i) to ferment both hexose and pentose sugars present in lignocellulose and (ii) to tolerate and to remain active in presence of inhibiting compounds generated during lignocellulose pretreatment and hydrolysis. In this review we focus on the development of strains of baker's yeast Saccharomyces cerevisiae. We discuss genetic and metabolic engineering strategies that have been used to improve, independently, xylose fermentation and strain tolerance.... (More)
The 2nd generation bioethanol will be produced from lignocellulose biomass including agricultural residues such as bagasse, straw, and stover, forest products residues and dedicated energy crops. The bioconversion of lignocellulose raw materials to ethanol requires microorganisms that are able (i) to ferment both hexose and pentose sugars present in lignocellulose and (ii) to tolerate and to remain active in presence of inhibiting compounds generated during lignocellulose pretreatment and hydrolysis. In this review we focus on the development of strains of baker's yeast Saccharomyces cerevisiae. We discuss genetic and metabolic engineering strategies that have been used to improve, independently, xylose fermentation and strain tolerance. Then, we deliberate strategies for simultaneous improvement of xylose utilization and inhibitor tolerance, with the view that a new generation of xylose-utilizing S. cerevisiae strains harboring beneficial traits for xylose consumption and inhibitor tolerance is expected to be available in the foreseeable future. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lignocellulose, ethanol, fermentation inhibitors, xylose
in
International Sugar Journal
volume
111
issue
1323
pages
172 - 180
publisher
Int Sugar Journal Ltd
external identifiers
  • wos:000264305100014
  • scopus:63049123654
ISSN
0020-8841
language
English
LU publication?
yes
id
4cd702af-6b27-4878-904f-1ca476134498 (old id 1401843)
date added to LUP
2009-06-15 09:43:03
date last changed
2017-02-26 03:50:38
@article{4cd702af-6b27-4878-904f-1ca476134498,
  abstract     = {The 2nd generation bioethanol will be produced from lignocellulose biomass including agricultural residues such as bagasse, straw, and stover, forest products residues and dedicated energy crops. The bioconversion of lignocellulose raw materials to ethanol requires microorganisms that are able (i) to ferment both hexose and pentose sugars present in lignocellulose and (ii) to tolerate and to remain active in presence of inhibiting compounds generated during lignocellulose pretreatment and hydrolysis. In this review we focus on the development of strains of baker's yeast Saccharomyces cerevisiae. We discuss genetic and metabolic engineering strategies that have been used to improve, independently, xylose fermentation and strain tolerance. Then, we deliberate strategies for simultaneous improvement of xylose utilization and inhibitor tolerance, with the view that a new generation of xylose-utilizing S. cerevisiae strains harboring beneficial traits for xylose consumption and inhibitor tolerance is expected to be available in the foreseeable future.},
  author       = {Almeida, Joao and Hahn-Hägerdal, Bärbel},
  issn         = {0020-8841},
  keyword      = {lignocellulose,ethanol,fermentation inhibitors,xylose},
  language     = {eng},
  number       = {1323},
  pages        = {172--180},
  publisher    = {Int Sugar Journal Ltd},
  series       = {International Sugar Journal},
  title        = {Developing Saccharomyces cerevisiae strains for second generation bioethanol: Improving xylose fermentation and inhibitor tolerance},
  volume       = {111},
  year         = {2009},
}