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The role of CD1d-restricted NK T lymphocytes in the immune response to oral infection with Salmonella typhimurium.

Berntman, Emma LU ; Rolf, Julia LU ; Johansson, Cecilia LU ; Anderson, Per LU and Cardell, Susanna LU (2005) In European Journal of Immunology 35(7). p.2100-2109
Abstract
CD1d-restricted natural killer T (NKT) cells belong to the innate-like lymphocytes which respond rapidly to stress and infectious challenge. We have studied murine CD1d-restricted NKT cells in the early immune response to virulent Salmonella enterica serovar Typhimurium after oral infection. In the liver and spleen, neutrophil and macrophage numbers had increased several-fold by day 5 post-infection, while the frequency of B and T lymphocytes decreased. These cellular changes occurred independently of CD1d-restricted NKT cells, and further, CD1d-restricted T cells did not influence the bacterial load. However, in CD1d+ mice NK1.1+ T cells and invariant CD1d-restricted T cells were activated by the infection, as demonstrated by an increase... (More)
CD1d-restricted natural killer T (NKT) cells belong to the innate-like lymphocytes which respond rapidly to stress and infectious challenge. We have studied murine CD1d-restricted NKT cells in the early immune response to virulent Salmonella enterica serovar Typhimurium after oral infection. In the liver and spleen, neutrophil and macrophage numbers had increased several-fold by day 5 post-infection, while the frequency of B and T lymphocytes decreased. These cellular changes occurred independently of CD1d-restricted NKT cells, and further, CD1d-restricted T cells did not influence the bacterial load. However, in CD1d+ mice NK1.1+ T cells and invariant CD1d-restricted T cells were activated by the infection, as demonstrated by an increase in size, up-regulation of CD69 and production of IFN-. The NK1.1 antigen was down-modulated on these cells during the course of infection, while TCR levels were unaffected. While dendritic cells (DC) up-regulated CD1d-levels upon 24 h of in vitro exposure to the bacteria, increased CD1d expression was not evident on DC in vivo during infection. Furthermore, in vitro re-stimulation of CD1d-restricted T cells isolated from infected mice demonstrated a significant skewing of the cytokine profile, with suppressed IL-4 and increased IFN- production. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Immunology
volume
35
issue
7
pages
2100 - 2109
publisher
John Wiley & Sons
external identifiers
  • pmid:15940666
  • wos:000230745000011
  • scopus:22544477540
ISSN
1521-4141
DOI
10.1002/eji.200425846
language
English
LU publication?
yes
id
3b1c9605-ee00-4ef1-a0ef-16f785b95e17 (old id 140188)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15940666
date added to LUP
2007-07-10 12:34:57
date last changed
2017-07-30 04:52:15
@article{3b1c9605-ee00-4ef1-a0ef-16f785b95e17,
  abstract     = {CD1d-restricted natural killer T (NKT) cells belong to the innate-like lymphocytes which respond rapidly to stress and infectious challenge. We have studied murine CD1d-restricted NKT cells in the early immune response to virulent Salmonella enterica serovar Typhimurium after oral infection. In the liver and spleen, neutrophil and macrophage numbers had increased several-fold by day 5 post-infection, while the frequency of B and T lymphocytes decreased. These cellular changes occurred independently of CD1d-restricted NKT cells, and further, CD1d-restricted T cells did not influence the bacterial load. However, in CD1d+ mice NK1.1+ T cells and invariant CD1d-restricted T cells were activated by the infection, as demonstrated by an increase in size, up-regulation of CD69 and production of IFN-. The NK1.1 antigen was down-modulated on these cells during the course of infection, while TCR levels were unaffected. While dendritic cells (DC) up-regulated CD1d-levels upon 24 h of in vitro exposure to the bacteria, increased CD1d expression was not evident on DC in vivo during infection. Furthermore, in vitro re-stimulation of CD1d-restricted T cells isolated from infected mice demonstrated a significant skewing of the cytokine profile, with suppressed IL-4 and increased IFN- production.},
  author       = {Berntman, Emma and Rolf, Julia and Johansson, Cecilia and Anderson, Per and Cardell, Susanna},
  issn         = {1521-4141},
  language     = {eng},
  number       = {7},
  pages        = {2100--2109},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Immunology},
  title        = {The role of CD1d-restricted NK T lymphocytes in the immune response to oral infection with Salmonella typhimurium.},
  url          = {http://dx.doi.org/10.1002/eji.200425846},
  volume       = {35},
  year         = {2005},
}