The role of CD1d-restricted NK T lymphocytes in the immune response to oral infection with Salmonella typhimurium.
(2005) In European Journal of Immunology 35(7). p.2100-2109- Abstract
- CD1d-restricted natural killer T (NKT) cells belong to the innate-like lymphocytes which respond rapidly to stress and infectious challenge. We have studied murine CD1d-restricted NKT cells in the early immune response to virulent Salmonella enterica serovar Typhimurium after oral infection. In the liver and spleen, neutrophil and macrophage numbers had increased several-fold by day 5 post-infection, while the frequency of B and T lymphocytes decreased. These cellular changes occurred independently of CD1d-restricted NKT cells, and further, CD1d-restricted T cells did not influence the bacterial load. However, in CD1d+ mice NK1.1+ T cells and invariant CD1d-restricted T cells were activated by the infection, as demonstrated by an increase... (More)
- CD1d-restricted natural killer T (NKT) cells belong to the innate-like lymphocytes which respond rapidly to stress and infectious challenge. We have studied murine CD1d-restricted NKT cells in the early immune response to virulent Salmonella enterica serovar Typhimurium after oral infection. In the liver and spleen, neutrophil and macrophage numbers had increased several-fold by day 5 post-infection, while the frequency of B and T lymphocytes decreased. These cellular changes occurred independently of CD1d-restricted NKT cells, and further, CD1d-restricted T cells did not influence the bacterial load. However, in CD1d+ mice NK1.1+ T cells and invariant CD1d-restricted T cells were activated by the infection, as demonstrated by an increase in size, up-regulation of CD69 and production of IFN-. The NK1.1 antigen was down-modulated on these cells during the course of infection, while TCR levels were unaffected. While dendritic cells (DC) up-regulated CD1d-levels upon 24 h of in vitro exposure to the bacteria, increased CD1d expression was not evident on DC in vivo during infection. Furthermore, in vitro re-stimulation of CD1d-restricted T cells isolated from infected mice demonstrated a significant skewing of the cytokine profile, with suppressed IL-4 and increased IFN- production. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/140188
- author
- Berntman, Emma LU ; Rolf, Julia LU ; Johansson, Cecilia LU ; Anderson, Per LU and Cardell, Susanna LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Immunology
- volume
- 35
- issue
- 7
- pages
- 2100 - 2109
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:15940666
- wos:000230745000011
- scopus:22544477540
- pmid:15940666
- ISSN
- 1521-4141
- DOI
- 10.1002/eji.200425846
- language
- English
- LU publication?
- yes
- id
- 3b1c9605-ee00-4ef1-a0ef-16f785b95e17 (old id 140188)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15940666
- date added to LUP
- 2016-04-04 08:56:23
- date last changed
- 2022-01-29 07:55:48
@article{3b1c9605-ee00-4ef1-a0ef-16f785b95e17, abstract = {{CD1d-restricted natural killer T (NKT) cells belong to the innate-like lymphocytes which respond rapidly to stress and infectious challenge. We have studied murine CD1d-restricted NKT cells in the early immune response to virulent Salmonella enterica serovar Typhimurium after oral infection. In the liver and spleen, neutrophil and macrophage numbers had increased several-fold by day 5 post-infection, while the frequency of B and T lymphocytes decreased. These cellular changes occurred independently of CD1d-restricted NKT cells, and further, CD1d-restricted T cells did not influence the bacterial load. However, in CD1d+ mice NK1.1+ T cells and invariant CD1d-restricted T cells were activated by the infection, as demonstrated by an increase in size, up-regulation of CD69 and production of IFN-. The NK1.1 antigen was down-modulated on these cells during the course of infection, while TCR levels were unaffected. While dendritic cells (DC) up-regulated CD1d-levels upon 24 h of in vitro exposure to the bacteria, increased CD1d expression was not evident on DC in vivo during infection. Furthermore, in vitro re-stimulation of CD1d-restricted T cells isolated from infected mice demonstrated a significant skewing of the cytokine profile, with suppressed IL-4 and increased IFN- production.}}, author = {{Berntman, Emma and Rolf, Julia and Johansson, Cecilia and Anderson, Per and Cardell, Susanna}}, issn = {{1521-4141}}, language = {{eng}}, number = {{7}}, pages = {{2100--2109}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Immunology}}, title = {{The role of CD1d-restricted NK T lymphocytes in the immune response to oral infection with Salmonella typhimurium.}}, url = {{http://dx.doi.org/10.1002/eji.200425846}}, doi = {{10.1002/eji.200425846}}, volume = {{35}}, year = {{2005}}, }