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Once-weekly oral medication with alendronate does not prevent migration of knee prostheses

Hansson, Ulrik LU ; Toksvig-Larsen, Sören LU ; Ryd, Leif LU and Aspenberg, Per LU (2009) In Acta Orthopaedica 80(1). p.41-45
Abstract
Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. Patients and methods We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The... (More)
Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. Patients and methods We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years. Results There was no difference in migration of implants between the two groups. Conclusion With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Osteoarthritis, Knee: surgery, Bone Resorption: radiography, Bone Remodeling: drug effects, Bone Density Conservation Agents: administration & dosage, Bone Density: drug effects, Alendronate: administration & dosage, Knee: adverse effects, Replacement, Arthroplasty
in
Acta Orthopaedica
volume
80
issue
1
pages
41 - 45
publisher
Taylor & Francis
external identifiers
  • wos:000264347300009
  • pmid:19297788
  • scopus:61649126840
ISSN
1745-3682
DOI
10.1080/17453670902804968
language
English
LU publication?
yes
id
bbd22423-ddc6-46de-894b-30bd4bb8395a (old id 1402436)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19297788?dopt=Abstract
date added to LUP
2009-06-15 09:44:36
date last changed
2017-06-11 03:26:35
@article{bbd22423-ddc6-46de-894b-30bd4bb8395a,
  abstract     = {Background and purpose Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. Patients and methods We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years. Results There was no difference in migration of implants between the two groups. Conclusion With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.},
  author       = {Hansson, Ulrik and Toksvig-Larsen, Sören and Ryd, Leif and Aspenberg, Per},
  issn         = {1745-3682},
  keyword      = {Osteoarthritis,Knee: surgery,Bone Resorption: radiography,Bone Remodeling: drug effects,Bone Density Conservation Agents: administration & dosage,Bone Density: drug effects,Alendronate: administration & dosage,Knee: adverse effects,Replacement,Arthroplasty},
  language     = {eng},
  number       = {1},
  pages        = {41--45},
  publisher    = {Taylor & Francis},
  series       = {Acta Orthopaedica},
  title        = {Once-weekly oral medication with alendronate does not prevent migration of knee prostheses},
  url          = {http://dx.doi.org/10.1080/17453670902804968},
  volume       = {80},
  year         = {2009},
}