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Adsorption of Intact Cubic Liquid Crystalline Nanoparticles on Hydrophilic Surfaces: Lateral Organization, Interfacial Stability, Layer Structure, and Interaction Mechanism

Vandoolaeghe, Pauline LU ; Campbell, Richard A.; Rennie, Adrian R. and Nylander, Tommy LU (2009) In Journal of Physical Chemistry C 113(11). p.4483-4494
Abstract
Liquid crystalline cubic phase nanoparticles (known as Cubosome), based on glycerol monooleate and stabilized by a nonionic block copolymer (Pluronic F-127), adsorb intact on hydrophilic silica in the presence of an electrolyte, except at high pH. To characterize the nature of the interaction, four techniques were applied in situ: fluorescence microscopy, quartz crystal microbalance with dissipation monitoring, neutron reflectivity, and null ellipsometry. The surface binding process occurs with no lateral ordering. There is no indication of collapse and spreading of the particles over a period of several hours. Even over much longer time scales (>45 h), there is no sign of relaxation or transition of the cubic phase internal structure... (More)
Liquid crystalline cubic phase nanoparticles (known as Cubosome), based on glycerol monooleate and stabilized by a nonionic block copolymer (Pluronic F-127), adsorb intact on hydrophilic silica in the presence of an electrolyte, except at high pH. To characterize the nature of the interaction, four techniques were applied in situ: fluorescence microscopy, quartz crystal microbalance with dissipation monitoring, neutron reflectivity, and null ellipsometry. The surface binding process occurs with no lateral ordering. There is no indication of collapse and spreading of the particles over a period of several hours. Even over much longer time scales (>45 h), there is no sign of relaxation or transition of the cubic phase internal structure of the adsorbed nanoparticles. Measurements of the adsorption kinetics with respect to three physical parameters allow us to propose an interaction mechanism where residual free polymer molecules present in the nanoparticle dispersions adsorb rapidly to the surface, and the nanoparticles adsorb more slowly in the gaps. The adsorption process is discussed as an interplay between repulsive and attractive forces, involving both the lipid and polymer components of the nanoparticles as well as the charge on the silica surface. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Physical Chemistry C
volume
113
issue
11
pages
4483 - 4494
publisher
The American Chemical Society
external identifiers
  • wos:000264111300041
  • scopus:65249153522
ISSN
1932-7447
DOI
10.1021/jp807314s
language
English
LU publication?
yes
id
ed4a9f03-53db-449d-890a-a59a32469ac7 (old id 1404845)
date added to LUP
2009-06-10 15:44:27
date last changed
2017-07-30 03:43:51
@article{ed4a9f03-53db-449d-890a-a59a32469ac7,
  abstract     = {Liquid crystalline cubic phase nanoparticles (known as Cubosome), based on glycerol monooleate and stabilized by a nonionic block copolymer (Pluronic F-127), adsorb intact on hydrophilic silica in the presence of an electrolyte, except at high pH. To characterize the nature of the interaction, four techniques were applied in situ: fluorescence microscopy, quartz crystal microbalance with dissipation monitoring, neutron reflectivity, and null ellipsometry. The surface binding process occurs with no lateral ordering. There is no indication of collapse and spreading of the particles over a period of several hours. Even over much longer time scales (>45 h), there is no sign of relaxation or transition of the cubic phase internal structure of the adsorbed nanoparticles. Measurements of the adsorption kinetics with respect to three physical parameters allow us to propose an interaction mechanism where residual free polymer molecules present in the nanoparticle dispersions adsorb rapidly to the surface, and the nanoparticles adsorb more slowly in the gaps. The adsorption process is discussed as an interplay between repulsive and attractive forces, involving both the lipid and polymer components of the nanoparticles as well as the charge on the silica surface.},
  author       = {Vandoolaeghe, Pauline and Campbell, Richard A. and Rennie, Adrian R. and Nylander, Tommy},
  issn         = {1932-7447},
  language     = {eng},
  number       = {11},
  pages        = {4483--4494},
  publisher    = {The American Chemical Society},
  series       = {Journal of Physical Chemistry C},
  title        = {Adsorption of Intact Cubic Liquid Crystalline Nanoparticles on Hydrophilic Surfaces: Lateral Organization, Interfacial Stability, Layer Structure, and Interaction Mechanism},
  url          = {http://dx.doi.org/10.1021/jp807314s},
  volume       = {113},
  year         = {2009},
}