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Neurogenesis in stroke and epilepsy

Kokaia, Zaal LU ; Arvidsson, Andreas LU ; Ekdahl Clementson, Christine LU and Lindvall, Olle LU (2004) 12th Colloque on Medicine and Research in Neurosciences In Stem Cells in the Nervous System: Functional and Clinical Implications (Research and Perspectives in Neurosciences) p.139-146
Abstract
Ischemic and epileptic insults promote neurogenesis from neural stem cells located in the dentate subgranular zone and in the subventricular zone lining the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior periventricle to the damaged striatum and CA1 region, respectively. Here they express morphological markers characteristic of those neurons that have died, and some evidence indicates that these neurons can re-establish connections. However, we still lack much information about the regulation of insult-induced neurogenesis and its behavioral... (More)
Ischemic and epileptic insults promote neurogenesis from neural stem cells located in the dentate subgranular zone and in the subventricular zone lining the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior periventricle to the damaged striatum and CA1 region, respectively. Here they express morphological markers characteristic of those neurons that have died, and some evidence indicates that these neurons can re-establish connections. However, we still lack much information about the regulation of insult-induced neurogenesis and its behavioral consequences. The new neurons may contribute to functional recovery but have also been suggested to be involved. in the development of epilepsy. (Less)
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Stem Cells in the Nervous System: Functional and Clinical Implications (Research and Perspectives in Neurosciences)
pages
139 - 146
publisher
Springer
conference name
12th Colloque on Medicine and Research in Neurosciences
external identifiers
  • wos:000189504400010
ISSN
0945-6082
ISBN
978-3-540-20558-6
language
English
LU publication?
yes
id
2a6d30d3-1e9a-4577-8e7b-422b12089a4d (old id 1406683)
date added to LUP
2009-06-03 13:11:52
date last changed
2016-04-16 04:57:14
@inproceedings{2a6d30d3-1e9a-4577-8e7b-422b12089a4d,
  abstract     = {Ischemic and epileptic insults promote neurogenesis from neural stem cells located in the dentate subgranular zone and in the subventricular zone lining the lateral ventricles. These findings raise the possibility that the adult brain tries to use its own stem cells to repair itself. New neurons generated by ischemic insults have now been shown to migrate from the subventricular zone and posterior periventricle to the damaged striatum and CA1 region, respectively. Here they express morphological markers characteristic of those neurons that have died, and some evidence indicates that these neurons can re-establish connections. However, we still lack much information about the regulation of insult-induced neurogenesis and its behavioral consequences. The new neurons may contribute to functional recovery but have also been suggested to be involved. in the development of epilepsy.},
  author       = {Kokaia, Zaal and Arvidsson, Andreas and Ekdahl Clementson, Christine and Lindvall, Olle},
  booktitle    = {Stem Cells in the Nervous System: Functional and Clinical Implications (Research and Perspectives in Neurosciences)},
  isbn         = {978-3-540-20558-6},
  issn         = {0945-6082},
  language     = {eng},
  pages        = {139--146},
  publisher    = {Springer},
  title        = {Neurogenesis in stroke and epilepsy},
  year         = {2004},
}