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CD27(-) CD4(+) memory T cells define a differentiated memory population at both the functional and transcriptional levels

Schiött, Åsa LU ; Lindstedt, Malin LU ; Johansson Lindbom, Bengt LU ; Roggen, E and Borrebaeck, Carl LU (2004) In Immunology 113(3). p.363-370
Abstract
The memory T-cell population is a heterogeneous population, including both effector cells, which exert a direct secondary immune response, and resting or intermediate cells, which serve as a reservoir and exert a possible regulatory role. To further dissect the T-cell memory population residing in the CD4(+) CD45RO(+) T-cell pool, we studied the functional properties of memory populations identified by the CD27 marker. This marker clearly divides the memory population into two groups. One group consists of effector cells lacking CD27 and displaying a high antigen recall response. The other group consists of an intermediate memory population, displaying CD27. This latter group lacks an antigen recall response and requires costimulation for... (More)
The memory T-cell population is a heterogeneous population, including both effector cells, which exert a direct secondary immune response, and resting or intermediate cells, which serve as a reservoir and exert a possible regulatory role. To further dissect the T-cell memory population residing in the CD4(+) CD45RO(+) T-cell pool, we studied the functional properties of memory populations identified by the CD27 marker. This marker clearly divides the memory population into two groups. One group consists of effector cells lacking CD27 and displaying a high antigen recall response. The other group consists of an intermediate memory population, displaying CD27. This latter group lacks an antigen recall response and requires costimulation for T-cell receptor triggering. To evaluate the function of the CD27(+) memory pool, we analysed the transcriptional profile, using high-density microarray technology. These gene data strongly support the different functional profiles of CD27(+) and CD27(-) memory populations, in terms of protein expression and the capacity to respond to antigen. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunology
volume
113
issue
3
pages
363 - 370
publisher
Wiley-Blackwell
external identifiers
  • wos:000224634000010
  • pmid:15500623
  • scopus:8144221903
ISSN
0019-2805
DOI
10.1111/j.1365-2567.2004.01974.x
language
English
LU publication?
yes
id
2624f16d-7bb0-4293-b767-80e917825d8e (old id 140765)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15500623&query_hl=60
date added to LUP
2007-07-10 09:49:43
date last changed
2017-11-05 03:32:18
@article{2624f16d-7bb0-4293-b767-80e917825d8e,
  abstract     = {The memory T-cell population is a heterogeneous population, including both effector cells, which exert a direct secondary immune response, and resting or intermediate cells, which serve as a reservoir and exert a possible regulatory role. To further dissect the T-cell memory population residing in the CD4(+) CD45RO(+) T-cell pool, we studied the functional properties of memory populations identified by the CD27 marker. This marker clearly divides the memory population into two groups. One group consists of effector cells lacking CD27 and displaying a high antigen recall response. The other group consists of an intermediate memory population, displaying CD27. This latter group lacks an antigen recall response and requires costimulation for T-cell receptor triggering. To evaluate the function of the CD27(+) memory pool, we analysed the transcriptional profile, using high-density microarray technology. These gene data strongly support the different functional profiles of CD27(+) and CD27(-) memory populations, in terms of protein expression and the capacity to respond to antigen.},
  author       = {Schiött, Åsa and Lindstedt, Malin and Johansson Lindbom, Bengt and Roggen, E and Borrebaeck, Carl},
  issn         = {0019-2805},
  language     = {eng},
  number       = {3},
  pages        = {363--370},
  publisher    = {Wiley-Blackwell},
  series       = {Immunology},
  title        = {CD27(-) CD4(+) memory T cells define a differentiated memory population at both the functional and transcriptional levels},
  url          = {http://dx.doi.org/10.1111/j.1365-2567.2004.01974.x},
  volume       = {113},
  year         = {2004},
}