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3-Hydroxypropionic acid as a nematicidal principle in endophytic fungi

Schwarz, M; Kopcke, B; Weber, R W S; Sterner, Olov LU and Anke, H (2004) In Phytochemistry 65(15). p.2239-2245
Abstract
3-Hydroxypropionic acid was isolated by bioactivity-guided fractionation of extracts obtained from submerged cultures of several endophytic fungi isolated from above-ground plant organs. This compound showed selective nematicidal activity against the plant-parasitic nematode Meloidogyne incognita with LD50 values of 12.5-15 mug/ml. Activity against the saprophytic Caenorhabditis elegans was fivefold lower. No antimicrobial, cytotoxic or phytotoxic effects were observed. Propionic acid and D- and L-lactic acids were not active against either nematode species. Based on morphological features and ITS, 18S and 28S rDNA analyses, the producing strains were identified as Phomopsis phaseoli isolated from the leaf of a tropical tree, and four... (More)
3-Hydroxypropionic acid was isolated by bioactivity-guided fractionation of extracts obtained from submerged cultures of several endophytic fungi isolated from above-ground plant organs. This compound showed selective nematicidal activity against the plant-parasitic nematode Meloidogyne incognita with LD50 values of 12.5-15 mug/ml. Activity against the saprophytic Caenorhabditis elegans was fivefold lower. No antimicrobial, cytotoxic or phytotoxic effects were observed. Propionic acid and D- and L-lactic acids were not active against either nematode species. Based on morphological features and ITS, 18S and 28S rDNA analyses, the producing strains were identified as Phomopsis phaseoli isolated from the leaf of a tropical tree, and four strains of Melanconium betulinum isolated from twigs of Betula pendula and B. pubescens in Germany. This is the first report of 3-hydroxypropionic acid in fungi, and of the nematicidal activity of this metabolite. (C) 2004 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Phytochemistry
volume
65
issue
15
pages
2239 - 2245
publisher
Elsevier
external identifiers
  • pmid:15587708
  • wos:000224006800008
  • scopus:4344717787
ISSN
0031-9422
DOI
10.1016/j.phytochem.2004.06.035
language
English
LU publication?
yes
id
da7ca0f2-8831-4029-aab0-1ff15a07528b (old id 141168)
date added to LUP
2007-07-10 14:32:44
date last changed
2017-12-10 04:33:34
@article{da7ca0f2-8831-4029-aab0-1ff15a07528b,
  abstract     = {3-Hydroxypropionic acid was isolated by bioactivity-guided fractionation of extracts obtained from submerged cultures of several endophytic fungi isolated from above-ground plant organs. This compound showed selective nematicidal activity against the plant-parasitic nematode Meloidogyne incognita with LD50 values of 12.5-15 mug/ml. Activity against the saprophytic Caenorhabditis elegans was fivefold lower. No antimicrobial, cytotoxic or phytotoxic effects were observed. Propionic acid and D- and L-lactic acids were not active against either nematode species. Based on morphological features and ITS, 18S and 28S rDNA analyses, the producing strains were identified as Phomopsis phaseoli isolated from the leaf of a tropical tree, and four strains of Melanconium betulinum isolated from twigs of Betula pendula and B. pubescens in Germany. This is the first report of 3-hydroxypropionic acid in fungi, and of the nematicidal activity of this metabolite. (C) 2004 Elsevier Ltd. All rights reserved.},
  author       = {Schwarz, M and Kopcke, B and Weber, R W S and Sterner, Olov and Anke, H},
  issn         = {0031-9422},
  language     = {eng},
  number       = {15},
  pages        = {2239--2245},
  publisher    = {Elsevier},
  series       = {Phytochemistry},
  title        = {3-Hydroxypropionic acid as a nematicidal principle in endophytic fungi},
  url          = {http://dx.doi.org/10.1016/j.phytochem.2004.06.035},
  volume       = {65},
  year         = {2004},
}