Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids
(2004) In Chemistry and Biodiversity 1(2). p.327-345- Abstract
- The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/141179
- author
- Danieli, B ; Giardini, A ; Lesma, G ; Passarella, D ; Silvani, A ; Appendino, G ; Noncovich, A ; Fontana, G ; Bombardelli, E and Sterner, Olov LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Chemistry and Biodiversity
- volume
- 1
- issue
- 2
- pages
- 327 - 345
- publisher
- Verlag Helvetica Chimica Acta
- external identifiers
-
- wos:000223765500010
- scopus:33645504486
- ISSN
- 1612-1872
- DOI
- 10.1002/cbdv.200490029
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 8efb5aa3-5848-4ab1-b714-1c4703619f25 (old id 141179)
- date added to LUP
- 2016-04-01 11:33:43
- date last changed
- 2022-01-26 07:03:42
@article{8efb5aa3-5848-4ab1-b714-1c4703619f25, abstract = {{The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.}}, author = {{Danieli, B and Giardini, A and Lesma, G and Passarella, D and Silvani, A and Appendino, G and Noncovich, A and Fontana, G and Bombardelli, E and Sterner, Olov}}, issn = {{1612-1872}}, language = {{eng}}, number = {{2}}, pages = {{327--345}}, publisher = {{Verlag Helvetica Chimica Acta}}, series = {{Chemistry and Biodiversity}}, title = {{Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids}}, url = {{http://dx.doi.org/10.1002/cbdv.200490029}}, doi = {{10.1002/cbdv.200490029}}, volume = {{1}}, year = {{2004}}, }