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Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids

Danieli, B; Giardini, A; Lesma, G; Passarella, D; Silvani, A; Appendino, G; Noncovich, A; Fontana, G; Bombardelli, E and Sterner, Olov LU (2004) In Chemistry and Biodiversity 1(2). p.327-345
Abstract
The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemistry and Biodiversity
volume
1
issue
2
pages
327 - 345
publisher
Verlag Helvetica Chimica Acta
external identifiers
  • wos:000223765500010
  • scopus:33645504486
ISSN
1612-1872
DOI
10.1002/cbdv.200490029
language
English
LU publication?
yes
id
8efb5aa3-5848-4ab1-b714-1c4703619f25 (old id 141179)
date added to LUP
2007-07-10 09:31:03
date last changed
2017-02-26 03:23:54
@article{8efb5aa3-5848-4ab1-b714-1c4703619f25,
  abstract     = {The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.},
  author       = {Danieli, B and Giardini, A and Lesma, G and Passarella, D and Silvani, A and Appendino, G and Noncovich, A and Fontana, G and Bombardelli, E and Sterner, Olov},
  issn         = {1612-1872},
  language     = {eng},
  number       = {2},
  pages        = {327--345},
  publisher    = {Verlag Helvetica Chimica Acta},
  series       = {Chemistry and Biodiversity},
  title        = {Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids},
  url          = {http://dx.doi.org/10.1002/cbdv.200490029},
  volume       = {1},
  year         = {2004},
}