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Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale

Rether, J ; Erkel, G ; Anke, T and Sterner, Olov LU (2004) In Biological Chemistry 385(9). p.829-834
Abstract
In a search for compounds inhibiting the inducible TNF-alpha promoter activity in T cells, a new spirocompound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-alpha promoterdriven luciferase reporter gene expression with an IC50 value of 2.5 mug/ml (10 muM) in TPA/ionomycinstimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the activation of the transcription factor NF-kappaB, which is involved in the inducible expression of many proinflammatory genes.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biological Chemistry
volume
385
issue
9
pages
829 - 834
publisher
De Gruyter
external identifiers
  • wos:000223772900009
  • pmid:15493878
  • scopus:5044221540
ISSN
1437-4315
DOI
10.1515/BC.2004.108
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
eba00987-69cb-435d-a79f-4681b91fe9d5 (old id 141191)
date added to LUP
2016-04-01 12:34:37
date last changed
2022-01-27 07:00:41
@article{eba00987-69cb-435d-a79f-4681b91fe9d5,
  abstract     = {{In a search for compounds inhibiting the inducible TNF-alpha promoter activity in T cells, a new spirocompound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-alpha promoterdriven luciferase reporter gene expression with an IC50 value of 2.5 mug/ml (10 muM) in TPA/ionomycinstimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the activation of the transcription factor NF-kappaB, which is involved in the inducible expression of many proinflammatory genes.}},
  author       = {{Rether, J and Erkel, G and Anke, T and Sterner, Olov}},
  issn         = {{1437-4315}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{829--834}},
  publisher    = {{De Gruyter}},
  series       = {{Biological Chemistry}},
  title        = {{Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale}},
  url          = {{http://dx.doi.org/10.1515/BC.2004.108}},
  doi          = {{10.1515/BC.2004.108}},
  volume       = {{385}},
  year         = {{2004}},
}