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Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale

Rether, J; Erkel, G; Anke, T and Sterner, Olov LU (2004) In Biological Chemistry1996-01-01+01:00 385(9). p.829-834
Abstract
In a search for compounds inhibiting the inducible TNF-alpha promoter activity in T cells, a new spirocompound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-alpha promoterdriven luciferase reporter gene expression with an IC50 value of 2.5 mug/ml (10 muM) in TPA/ionomycinstimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the activation of the transcription factor NF-kappaB, which is involved in the inducible expression of many proinflammatory genes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biological Chemistry1996-01-01+01:00
volume
385
issue
9
pages
829 - 834
publisher
De Gruyter
external identifiers
  • wos:000223772900009
  • pmid:15493878
  • scopus:5044221540
ISSN
1437-4315
DOI
10.1515/BC.2004.108
language
English
LU publication?
yes
id
eba00987-69cb-435d-a79f-4681b91fe9d5 (old id 141191)
date added to LUP
2007-07-10 13:59:26
date last changed
2017-07-23 03:56:47
@article{eba00987-69cb-435d-a79f-4681b91fe9d5,
  abstract     = {In a search for compounds inhibiting the inducible TNF-alpha promoter activity in T cells, a new spirocompound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-alpha promoterdriven luciferase reporter gene expression with an IC50 value of 2.5 mug/ml (10 muM) in TPA/ionomycinstimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-alpha promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the activation of the transcription factor NF-kappaB, which is involved in the inducible expression of many proinflammatory genes.},
  author       = {Rether, J and Erkel, G and Anke, T and Sterner, Olov},
  issn         = {1437-4315},
  language     = {eng},
  number       = {9},
  pages        = {829--834},
  publisher    = {De Gruyter},
  series       = {Biological Chemistry1996-01-01+01:00},
  title        = {Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale},
  url          = {http://dx.doi.org/10.1515/BC.2004.108},
  volume       = {385},
  year         = {2004},
}