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Effects of adrenaline on longitudinal arterial wall movements and resulting intramural shear strain: a first report.

Rydén Ahlgren, Åsa LU ; Cinthio, Magnus LU ; Steen, Stig LU ; Persson, Hans W LU ; Sjöberg, Trygve LU and Lindström, Kjell LU (2009) In Clinical Physiology and Functional Imaging2002-01-01+01:00 29. p.353-359
Abstract
Using ultrasound we recently demonstrated that in central elastic arteries as well as in large muscular arteries in humans there is a distinct longitudinal displacement of the arterial wall during the cardiac cycle. Further, for the first time, we also demonstrated that the inner parts of the vessel wall, the intima-media complex, in these vessels exhibit a larger longitudinal displacement than the outer part of the vessel wall, the adventitial region, introducing the presence of substantial shear strain, and thus shear stress within the vessel wall. The role of these unexplored phenomena is unknown. Here, in a first study on the longitudinal movements of the porcine common carotid artery, we show that administration of adrenaline... (More)
Using ultrasound we recently demonstrated that in central elastic arteries as well as in large muscular arteries in humans there is a distinct longitudinal displacement of the arterial wall during the cardiac cycle. Further, for the first time, we also demonstrated that the inner parts of the vessel wall, the intima-media complex, in these vessels exhibit a larger longitudinal displacement than the outer part of the vessel wall, the adventitial region, introducing the presence of substantial shear strain, and thus shear stress within the vessel wall. The role of these unexplored phenomena is unknown. Here, in a first study on the longitudinal movements of the porcine common carotid artery, we show that administration of adrenaline (epinephrine) might have pronounced effects on the longitudinal displacement of the intima-media complex. In this experiment the longitudinal displacement of the intima-media complex increased >200% at the highest blood pressure levels as compared to baseline. Further, shear strain within the wall increased >250%; the longitudinal displacement of the adventitial region being smaller than that of the intima-media complex. Thus, our results indicate that adrenaline can markedly influence the longitudinal displacement of the arterial wall and the resulting shear strain, and thus shear stress, within the arterial wall. This opens up a new field within cardiovascular research, revealing a previously unknown mechanism in the circulatory system. Further studies on larger materials are needed to confirm our findings and to elucidate the underlying mechanisms and the physiological, pathophysiological and clinical implications of this phenomenon. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging2002-01-01+01:00
volume
29
pages
353 - 359
publisher
Wiley Online Library
external identifiers
  • wos:000268981800006
  • pmid:19453564
  • scopus:69149094379
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2009.00875.x
language
English
LU publication?
yes
id
43ac4caa-e723-4acc-bf13-d854bcee18fb (old id 1412160)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19453564?dopt=Abstract
date added to LUP
2009-06-04 09:08:02
date last changed
2017-05-21 04:32:25
@article{43ac4caa-e723-4acc-bf13-d854bcee18fb,
  abstract     = {Using ultrasound we recently demonstrated that in central elastic arteries as well as in large muscular arteries in humans there is a distinct longitudinal displacement of the arterial wall during the cardiac cycle. Further, for the first time, we also demonstrated that the inner parts of the vessel wall, the intima-media complex, in these vessels exhibit a larger longitudinal displacement than the outer part of the vessel wall, the adventitial region, introducing the presence of substantial shear strain, and thus shear stress within the vessel wall. The role of these unexplored phenomena is unknown. Here, in a first study on the longitudinal movements of the porcine common carotid artery, we show that administration of adrenaline (epinephrine) might have pronounced effects on the longitudinal displacement of the intima-media complex. In this experiment the longitudinal displacement of the intima-media complex increased >200% at the highest blood pressure levels as compared to baseline. Further, shear strain within the wall increased >250%; the longitudinal displacement of the adventitial region being smaller than that of the intima-media complex. Thus, our results indicate that adrenaline can markedly influence the longitudinal displacement of the arterial wall and the resulting shear strain, and thus shear stress, within the arterial wall. This opens up a new field within cardiovascular research, revealing a previously unknown mechanism in the circulatory system. Further studies on larger materials are needed to confirm our findings and to elucidate the underlying mechanisms and the physiological, pathophysiological and clinical implications of this phenomenon.},
  author       = {Rydén Ahlgren, Åsa and Cinthio, Magnus and Steen, Stig and Persson, Hans W and Sjöberg, Trygve and Lindström, Kjell},
  issn         = {1475-0961},
  language     = {eng},
  pages        = {353--359},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging2002-01-01+01:00},
  title        = {Effects of adrenaline on longitudinal arterial wall movements and resulting intramural shear strain: a first report.},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2009.00875.x},
  volume       = {29},
  year         = {2009},
}