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High hyperdiploid childhood acute lymphoblastic leukemia.

Paulsson, Kajsa LU and Johansson, Bertil LU (2009) In Genes, Chromosomes and Cancer 48. p.637-660
Abstract
High hyperdiploidy (51-67 chromosomes) is the most common cytogenetic abnormality pattern in childhood B-cell precursor acute lymphoblastic leukemia (ALL), occurring in 25-30% of such cases. High hyperdiploid ALL is characterized cytogenetically by a nonrandom gain of chromosomes X, 4, 6, 10, 14, 17, 18, and 21 and clinically by a favorable prognosis. Despite the high frequency of this karyotypic subgroup, many questions remain regarding the epidemiology, etiology, presence of other genetic changes, the time and cell of origin, and the formation and pathogenetic consequences of high hyperdiploidy. However, during the last few years, several studies have addressed some of these important issues, and these, as well as previous reports on... (More)
High hyperdiploidy (51-67 chromosomes) is the most common cytogenetic abnormality pattern in childhood B-cell precursor acute lymphoblastic leukemia (ALL), occurring in 25-30% of such cases. High hyperdiploid ALL is characterized cytogenetically by a nonrandom gain of chromosomes X, 4, 6, 10, 14, 17, 18, and 21 and clinically by a favorable prognosis. Despite the high frequency of this karyotypic subgroup, many questions remain regarding the epidemiology, etiology, presence of other genetic changes, the time and cell of origin, and the formation and pathogenetic consequences of high hyperdiploidy. However, during the last few years, several studies have addressed some of these important issues, and these, as well as previous reports on high hyperdiploid childhood ALL, are reviewed herein. (c) 2009 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes, Chromosomes and Cancer
volume
48
pages
637 - 660
publisher
John Wiley & Sons
external identifiers
  • wos:000267352300001
  • pmid:19415723
  • scopus:67650421868
ISSN
1045-2257
DOI
10.1002/gcc.20671
language
English
LU publication?
yes
id
f7c14b5f-c80a-4dac-bbee-4b5cc5f96d95 (old id 1412677)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19415723?dopt=Abstract
date added to LUP
2009-06-02 08:49:56
date last changed
2017-10-08 04:28:10
@article{f7c14b5f-c80a-4dac-bbee-4b5cc5f96d95,
  abstract     = {High hyperdiploidy (51-67 chromosomes) is the most common cytogenetic abnormality pattern in childhood B-cell precursor acute lymphoblastic leukemia (ALL), occurring in 25-30% of such cases. High hyperdiploid ALL is characterized cytogenetically by a nonrandom gain of chromosomes X, 4, 6, 10, 14, 17, 18, and 21 and clinically by a favorable prognosis. Despite the high frequency of this karyotypic subgroup, many questions remain regarding the epidemiology, etiology, presence of other genetic changes, the time and cell of origin, and the formation and pathogenetic consequences of high hyperdiploidy. However, during the last few years, several studies have addressed some of these important issues, and these, as well as previous reports on high hyperdiploid childhood ALL, are reviewed herein. (c) 2009 Wiley-Liss, Inc.},
  author       = {Paulsson, Kajsa and Johansson, Bertil},
  issn         = {1045-2257},
  language     = {eng},
  pages        = {637--660},
  publisher    = {John Wiley & Sons},
  series       = {Genes, Chromosomes and Cancer},
  title        = {High hyperdiploid childhood acute lymphoblastic leukemia.},
  url          = {http://dx.doi.org/10.1002/gcc.20671},
  volume       = {48},
  year         = {2009},
}