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Gladder cancer and the sentinel node concept

Liedberg, Fredrik LU ; Chebil, G.; Davidsson, Thomas LU ; Malmström, Per LU ; Sherif, A.; Thorn, M.; de la Torre, M. and Månsson, Wiking LU (2003) In Aktuelle Urologie 34(2). p.115-118
Abstract
Purpose: Lymph node status is one of the most important prognostic factors in muscle-invasive bladder cancer. The extent of lymphadenectomy performed in conjunction with cystectomy and the question as to whether this is a staging or therapeutic intervention are matters of discussion. The aim of this study was to evaluate the sentinel node (SN) concept and to correlate findings with tumour status in excised regional lymph nodes. Material and method: 26 patients scheduled for cystectomy were investigated with preoperative lymphoscintigraphy, peroperative dye detection (Patent Blue) and dynamic lymphoscintigraphy (Nanocoll or Albures 50 MBq/ml). The substances were injected adjacent to the tumour in the detrusor muscle. Results: Sentinel... (More)
Purpose: Lymph node status is one of the most important prognostic factors in muscle-invasive bladder cancer. The extent of lymphadenectomy performed in conjunction with cystectomy and the question as to whether this is a staging or therapeutic intervention are matters of discussion. The aim of this study was to evaluate the sentinel node (SN) concept and to correlate findings with tumour status in excised regional lymph nodes. Material and method: 26 patients scheduled for cystectomy were investigated with preoperative lymphoscintigraphy, peroperative dye detection (Patent Blue) and dynamic lymphoscintigraphy (Nanocoll or Albures 50 MBq/ml). The substances were injected adjacent to the tumour in the detrusor muscle. Results: Sentinel nodes were detected in 21 of the 26 of the investigated patients. 7/21 SN were located outside the obturator fossa. Of the eight patients with lymph node metastasis, five displayed metastasis in lymph nodes outside the obturator fossa. There was one false negative SN in a patient with multifocal tumour, while in the other seven patients with lymph node metastasis, these were detected in the SN. Conclusion: Sentinel node detection is possible in most cases of bladder cancer scheduled for cystectomy. The significance of utilizing this method to detect lymph node metastasis outside the obturator fossa warrants further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
INVASIVE BLADDER-CANCER, DISSECTION, RADICAL CYSTECTOMY, CARCINOMA, LYMPHADENECTOMY, METASTASES, sentinel node, BIOPSY, invasive, bladder cancer
in
Aktuelle Urologie
volume
34
issue
2
pages
115 - 118
publisher
Georg Thieme Verlag
external identifiers
  • pmid:14566695
  • wos:000182870100005
  • scopus:0037809376
ISSN
0001-7868
DOI
language
German
LU publication?
yes
id
f847df02-7ef0-4a7b-81ac-338a3d629dbf (old id 1417212)
date added to LUP
2009-06-16 16:50:46
date last changed
2018-05-29 10:05:08
@article{f847df02-7ef0-4a7b-81ac-338a3d629dbf,
  abstract     = {Purpose: Lymph node status is one of the most important prognostic factors in muscle-invasive bladder cancer. The extent of lymphadenectomy performed in conjunction with cystectomy and the question as to whether this is a staging or therapeutic intervention are matters of discussion. The aim of this study was to evaluate the sentinel node (SN) concept and to correlate findings with tumour status in excised regional lymph nodes. Material and method: 26 patients scheduled for cystectomy were investigated with preoperative lymphoscintigraphy, peroperative dye detection (Patent Blue) and dynamic lymphoscintigraphy (Nanocoll or Albures 50 MBq/ml). The substances were injected adjacent to the tumour in the detrusor muscle. Results: Sentinel nodes were detected in 21 of the 26 of the investigated patients. 7/21 SN were located outside the obturator fossa. Of the eight patients with lymph node metastasis, five displayed metastasis in lymph nodes outside the obturator fossa. There was one false negative SN in a patient with multifocal tumour, while in the other seven patients with lymph node metastasis, these were detected in the SN. Conclusion: Sentinel node detection is possible in most cases of bladder cancer scheduled for cystectomy. The significance of utilizing this method to detect lymph node metastasis outside the obturator fossa warrants further investigation.},
  author       = {Liedberg, Fredrik and Chebil, G. and Davidsson, Thomas and Malmström, Per and Sherif, A. and Thorn, M. and de la Torre, M. and Månsson, Wiking},
  issn         = {0001-7868},
  keyword      = {INVASIVE BLADDER-CANCER,DISSECTION,RADICAL CYSTECTOMY,CARCINOMA,LYMPHADENECTOMY,METASTASES,sentinel node,BIOPSY,invasive,bladder cancer},
  language     = {ger},
  number       = {2},
  pages        = {115--118},
  publisher    = {Georg Thieme Verlag},
  series       = {Aktuelle Urologie},
  title        = {Gladder cancer and the sentinel node concept},
  url          = {http://dx.doi.org/},
  volume       = {34},
  year         = {2003},
}