Advanced

Ethanol intake and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition (EPIC)

Rohrmann, Sabine; Linseisen, Jakob; Vrieling, Alina; Boffetta, Paolo; Stolzenberg-Solomon, Rachael Z.; Lowenfels, Albert B.; Jensen, Majken K.; Overvad, Kim; Olsen, Anja and Tjonneland, Anne, et al. (2009) In Cancer Causes and Control 20(5). p.785-794
Abstract
To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. Overall, neither ethanol intake at recruitment (relative... (More)
To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption. These results suggest no association of alcohol consumption with the risk of pancreatic cancer. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epidemiology, Ethanol, Pancreatic cancer, EPIC
in
Cancer Causes and Control
volume
20
issue
5
pages
785 - 794
publisher
Springer
external identifiers
  • wos:000266340200031
  • scopus:67349214047
ISSN
1573-7225
DOI
10.1007/s10552-008-9293-8
language
English
LU publication?
yes
id
b3428c0c-046f-4286-b3c8-b5cb14f8b614 (old id 1425350)
date added to LUP
2009-07-02 11:55:44
date last changed
2017-05-28 03:34:20
@article{b3428c0c-046f-4286-b3c8-b5cb14f8b614,
  abstract     = {To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption. These results suggest no association of alcohol consumption with the risk of pancreatic cancer.},
  author       = {Rohrmann, Sabine and Linseisen, Jakob and Vrieling, Alina and Boffetta, Paolo and Stolzenberg-Solomon, Rachael Z. and Lowenfels, Albert B. and Jensen, Majken K. and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Fagherazzi, G. and Misirli, Gesthimani and Lagiou, Pagona and Trichopoulou, Antonia and Kaaks, Rudolf and Bergmann, Manuela M. and Boeing, Heiner and Bingham, Sheila and Khaw, Kay-Tee and Allen, Naomi and Roddam, Andrew and Palli, Domenico and Pala, Valeria and Panico, Salvatore and Tumino, Rosario and Vineis, Paolo and Peeters, Petra H. M. and Hjartaker, Anette and Lund, Eiliv and Redondo Cornejo, Ma Luisa and Agudo, Antonio and Arriola, Larraitz and Sanchez, Maria-Jose and Tormo, Maria-Jose and Barricarte Gurrea, Aurelio and Lindkvist, Bjorn and Manjer, Jonas and Johansson, Ingegerd and Ye, Weimin and Slimani, Nadia and Duell, Eric J. and Jenab, Mazda and Michaud, Dominique S. and Mouw, Traci and Riboli, Elio and Bueno-de-Mesquita, H. Bas},
  issn         = {1573-7225},
  keyword      = {Epidemiology,Ethanol,Pancreatic cancer,EPIC},
  language     = {eng},
  number       = {5},
  pages        = {785--794},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Ethanol intake and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1007/s10552-008-9293-8},
  volume       = {20},
  year         = {2009},
}