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Insulin and free oestradiol are independent risk factors for benign prostatic hyperplasia

Hammarsten, J.; Damber, J-E; Karlsson, Magnus LU ; Knutson, T.; Ljunggren, O.; Ohlsson, C.; Peeker, R.; Smith, U. and Mellstrom, D. (2009) In Prostate Cancer and Prostatic Diseases 12(2). p.160-165
Abstract
The aetiology of benign prostatic hyperplasia (BPH) remains unclear. The objective of the present study was to test the insulin, oestradiol and metabolic syndrome hypotheses as promoters of BPH. The design was a risk factor analysis of BPH in which the total prostate gland volume was related to endocrine and anthropometric factors. The participants studied were 184 representative men, aged 72-76 years, residing in Goteborg, Sweden. Using a multivariate analysis, BPH as measured by the total prostate gland volume correlated statistically significantly with fasting serum insulin (beta = 0.200, P = 0.028), free oestradiol (beta = 0.233, P = 0.008) and lean body mass (beta = 0.257, P = 0.034). Insulin and free oestradiol appear to be... (More)
The aetiology of benign prostatic hyperplasia (BPH) remains unclear. The objective of the present study was to test the insulin, oestradiol and metabolic syndrome hypotheses as promoters of BPH. The design was a risk factor analysis of BPH in which the total prostate gland volume was related to endocrine and anthropometric factors. The participants studied were 184 representative men, aged 72-76 years, residing in Goteborg, Sweden. Using a multivariate analysis, BPH as measured by the total prostate gland volume correlated statistically significantly with fasting serum insulin (beta = 0.200, P = 0.028), free oestradiol (beta = 0.233, P = 0.008) and lean body mass (beta = 0.257, P = 0.034). Insulin and free oestradiol appear to be independent risk factors for BPH, confirming both the insulin and the oestradiol hypotheses. Our findings also seem to confirm the metabolic syndrome hypothesis. The metabolic syndrome and its major endocrine aberration, hyperinsulinaemia, are possible primary events in BPH. Prostate Cancer and Prostatic Diseases (2009) 12, 160-165; doi:10.1038/pcan.2008.50; published online 30 September 2008 (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lean body mass, benign prostatic hyperplasia, insulin, oestradiol, the, metabolic syndrome
in
Prostate Cancer and Prostatic Diseases
volume
12
issue
2
pages
160 - 165
publisher
Nature Publishing Group
external identifiers
  • wos:000265980600010
  • scopus:67349202437
ISSN
1476-5608
DOI
10.1038/pcan.2008.50
language
English
LU publication?
yes
id
7f99a167-f502-4f67-993d-a66b4f358bde (old id 1425819)
date added to LUP
2009-06-30 15:05:24
date last changed
2017-05-28 03:49:06
@article{7f99a167-f502-4f67-993d-a66b4f358bde,
  abstract     = {The aetiology of benign prostatic hyperplasia (BPH) remains unclear. The objective of the present study was to test the insulin, oestradiol and metabolic syndrome hypotheses as promoters of BPH. The design was a risk factor analysis of BPH in which the total prostate gland volume was related to endocrine and anthropometric factors. The participants studied were 184 representative men, aged 72-76 years, residing in Goteborg, Sweden. Using a multivariate analysis, BPH as measured by the total prostate gland volume correlated statistically significantly with fasting serum insulin (beta = 0.200, P = 0.028), free oestradiol (beta = 0.233, P = 0.008) and lean body mass (beta = 0.257, P = 0.034). Insulin and free oestradiol appear to be independent risk factors for BPH, confirming both the insulin and the oestradiol hypotheses. Our findings also seem to confirm the metabolic syndrome hypothesis. The metabolic syndrome and its major endocrine aberration, hyperinsulinaemia, are possible primary events in BPH. Prostate Cancer and Prostatic Diseases (2009) 12, 160-165; doi:10.1038/pcan.2008.50; published online 30 September 2008},
  author       = {Hammarsten, J. and Damber, J-E and Karlsson, Magnus and Knutson, T. and Ljunggren, O. and Ohlsson, C. and Peeker, R. and Smith, U. and Mellstrom, D.},
  issn         = {1476-5608},
  keyword      = {lean body mass,benign prostatic hyperplasia,insulin,oestradiol,the,metabolic syndrome},
  language     = {eng},
  number       = {2},
  pages        = {160--165},
  publisher    = {Nature Publishing Group},
  series       = {Prostate Cancer and Prostatic Diseases},
  title        = {Insulin and free oestradiol are independent risk factors for benign prostatic hyperplasia},
  url          = {http://dx.doi.org/10.1038/pcan.2008.50},
  volume       = {12},
  year         = {2009},
}