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Endogenous steroid hormone levels in early pregnancy and risk of testicular cancer in the offspring: A nested case-referent study

Holl, Katsiaryna; Lundin, Eva; Surcel, Helja-Marja; Grankvist, Kjell; Koskela, Pentti; Dillner, Joakim LU ; Hallmans, Goran; Wadell, Goran; Olafsdottir, Gudridur H. and Ogmundsdottir, Helga M., et al. (2009) In International Journal of Cancer 124(12). p.2923-2928
Abstract
According to the leading hypothesis on testicular cancer (TC) etiology exposure to a specific pattern of steroid hormones in utero, in particular, to high levels of estrogens and low levels of androgens is the major determinant of TC risk in the offspring. We performed a case-referent study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal endogenous steroid hormones with regard to the risk of TC. TC cases and referents were aged between 0 and 25 years. For each case-index mother pair, three or four matched referent-referent mother pairs Were identified using national population registries. First trimester or early second trimester sera were retrieved... (More)
According to the leading hypothesis on testicular cancer (TC) etiology exposure to a specific pattern of steroid hormones in utero, in particular, to high levels of estrogens and low levels of androgens is the major determinant of TC risk in the offspring. We performed a case-referent study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal endogenous steroid hormones with regard to the risk of TC. TC cases and referents were aged between 0 and 25 years. For each case-index mother pair, three or four matched referent-referent mother pairs Were identified using national population registries. First trimester or early second trimester sera were retrieved from the index mothers of 73 TC cases and 286 matched referent mothers, and were tested for dehydroepiandrosterone sulfate (DHEAS), androstenedione, testosterone, estradiol, estrone, and sex hormone binding globulin (SHBG,). Offspring of mothers with high DHEAS levels had a significantly decreased risk of TC (OR for highest vs. lowest DHEAS quartile, 0.18 (95% CI 0.06-0.58). In contrast, offspring of mothers With high androstenedione levels had ail increased risk of TC (OR 4.1; 95% CI 1.2-12.0). High maternal total estradiol level also tended to be associated with an increased risk of TC in the offspring (OR 32; 95% CI 0.98-1,090). We report the first direct evidence that interplay or maternal steroid hormones in the early pregnancy is important in the etiology of TC in the offspring. (C) 2009 UICC (Less)
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publication status
published
subject
keywords
offspring, testicular cancer, early pregnancy, endogenous steroid hormones
in
International Journal of Cancer
volume
124
issue
12
pages
2923 - 2928
publisher
John Wiley & Sons
external identifiers
  • wos:000265997500022
  • scopus:65649095141
ISSN
0020-7136
DOI
10.1002/ijc.24312
language
English
LU publication?
yes
id
b12c4346-c8ea-4b0c-adbb-a77ac57031bb (old id 1426021)
date added to LUP
2009-06-26 14:20:56
date last changed
2017-09-03 03:41:28
@article{b12c4346-c8ea-4b0c-adbb-a77ac57031bb,
  abstract     = {According to the leading hypothesis on testicular cancer (TC) etiology exposure to a specific pattern of steroid hormones in utero, in particular, to high levels of estrogens and low levels of androgens is the major determinant of TC risk in the offspring. We performed a case-referent study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal endogenous steroid hormones with regard to the risk of TC. TC cases and referents were aged between 0 and 25 years. For each case-index mother pair, three or four matched referent-referent mother pairs Were identified using national population registries. First trimester or early second trimester sera were retrieved from the index mothers of 73 TC cases and 286 matched referent mothers, and were tested for dehydroepiandrosterone sulfate (DHEAS), androstenedione, testosterone, estradiol, estrone, and sex hormone binding globulin (SHBG,). Offspring of mothers with high DHEAS levels had a significantly decreased risk of TC (OR for highest vs. lowest DHEAS quartile, 0.18 (95% CI 0.06-0.58). In contrast, offspring of mothers With high androstenedione levels had ail increased risk of TC (OR 4.1; 95% CI 1.2-12.0). High maternal total estradiol level also tended to be associated with an increased risk of TC in the offspring (OR 32; 95% CI 0.98-1,090). We report the first direct evidence that interplay or maternal steroid hormones in the early pregnancy is important in the etiology of TC in the offspring. (C) 2009 UICC},
  author       = {Holl, Katsiaryna and Lundin, Eva and Surcel, Helja-Marja and Grankvist, Kjell and Koskela, Pentti and Dillner, Joakim and Hallmans, Goran and Wadell, Goran and Olafsdottir, Gudridur H. and Ogmundsdottir, Helga M. and Pukkala, Eero and Lehtinen, Matti and Stattin, Par and Lukanova, Annekatrin},
  issn         = {0020-7136},
  keyword      = {offspring,testicular cancer,early pregnancy,endogenous steroid hormones},
  language     = {eng},
  number       = {12},
  pages        = {2923--2928},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Endogenous steroid hormone levels in early pregnancy and risk of testicular cancer in the offspring: A nested case-referent study},
  url          = {http://dx.doi.org/10.1002/ijc.24312},
  volume       = {124},
  year         = {2009},
}