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Long term effects on epileptiform activity with vagus nerve stimulation in children.

Hallböök, Tove LU ; Lundgren, Johan LU ; Blennow, Gösta LU ; Strömblad, Lars-Göran LU and Rosén, Ingmar LU (2005) In Seizure 14(8). p.527-533
Abstract
Purpose: We report tong-term effects of vagus nerve stimulation (VNS) on epileptiform activity in 15 children, and how these changes are related to activity stage and to clinical effects on seizure reduction, seizure severity (NHS3) and quality of life (QOL). Methods: Initially, and after 3 and 9 months of VNS-treatment, 15 children were investigated with 24 h ambulatory EEG monitoring for spike detection. The number of interictal epiteptiform discharges (IEDs) and the inter spike intervals (ISIs) were analysed during 2 h in the awake state, and 1 h of rapid eye movement (REM)-, spindle- and delta-steep, respectively. Total number and duration of electrographic seizure episodes were also analysed. Results: At 9 months the total number of... (More)
Purpose: We report tong-term effects of vagus nerve stimulation (VNS) on epileptiform activity in 15 children, and how these changes are related to activity stage and to clinical effects on seizure reduction, seizure severity (NHS3) and quality of life (QOL). Methods: Initially, and after 3 and 9 months of VNS-treatment, 15 children were investigated with 24 h ambulatory EEG monitoring for spike detection. The number of interictal epiteptiform discharges (IEDs) and the inter spike intervals (ISIs) were analysed during 2 h in the awake state, and 1 h of rapid eye movement (REM)-, spindle- and delta-steep, respectively. Total number and duration of electrographic seizure episodes were also analysed. Results: At 9 months the total number of IEDs was significantly reduced (p = 0.04). There was a tendency of reduction in all activity stages, and significantly so in delta-steep (p = 0.008). Total etectrographic seizure number was significantly reduced in the 24 h EEG at 3 and 9 months (p = 0.03, 0.05). There was a significant concordance in direction of changes in epileptiform activity and etectrographic seizures at 9 months (p = 0.04). Concordance in direction of changes was seen in 9 of 15 children between clinical seizures and IED (p > 0.3), in 10 of 15 children between QOL and IED (p = 0.3) and in 8 of 15 children between NHS3 and IED (p > 0.3). There was no direct correlation between the extent of improvement in these clinical data and the degree of spike reduction. Conclusion: This study shows that VNS reduces IEDs especially in REM and delta steep, as well as the number of electrographic seizures. It also shows a concordance between reduction in IEDs and etectrographic seizures. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
spike, EEG, epilepsy, vagus nerve stimulation, detection, children, seizure frequency
in
Seizure
volume
14
issue
8
pages
527 - 533
publisher
Elsevier
external identifiers
  • pmid:16098769
  • wos:000234072800001
  • scopus:28944453172
ISSN
1532-2688
DOI
10.1016/j.seizure.2005.07.004
language
English
LU publication?
yes
id
e4919b39-17c5-4861-833c-2a5e1ec26329 (old id 142782)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16098769&dopt=Abstract
http://www.sciencedirect.com/science/article/pii/S1059131105001238
date added to LUP
2007-07-13 15:36:22
date last changed
2017-05-21 04:21:51
@article{e4919b39-17c5-4861-833c-2a5e1ec26329,
  abstract     = {Purpose: We report tong-term effects of vagus nerve stimulation (VNS) on epileptiform activity in 15 children, and how these changes are related to activity stage and to clinical effects on seizure reduction, seizure severity (NHS3) and quality of life (QOL). Methods: Initially, and after 3 and 9 months of VNS-treatment, 15 children were investigated with 24 h ambulatory EEG monitoring for spike detection. The number of interictal epiteptiform discharges (IEDs) and the inter spike intervals (ISIs) were analysed during 2 h in the awake state, and 1 h of rapid eye movement (REM)-, spindle- and delta-steep, respectively. Total number and duration of electrographic seizure episodes were also analysed. Results: At 9 months the total number of IEDs was significantly reduced (p = 0.04). There was a tendency of reduction in all activity stages, and significantly so in delta-steep (p = 0.008). Total etectrographic seizure number was significantly reduced in the 24 h EEG at 3 and 9 months (p = 0.03, 0.05). There was a significant concordance in direction of changes in epileptiform activity and etectrographic seizures at 9 months (p = 0.04). Concordance in direction of changes was seen in 9 of 15 children between clinical seizures and IED (p > 0.3), in 10 of 15 children between QOL and IED (p = 0.3) and in 8 of 15 children between NHS3 and IED (p > 0.3). There was no direct correlation between the extent of improvement in these clinical data and the degree of spike reduction. Conclusion: This study shows that VNS reduces IEDs especially in REM and delta steep, as well as the number of electrographic seizures. It also shows a concordance between reduction in IEDs and etectrographic seizures.},
  author       = {Hallböök, Tove and Lundgren, Johan and Blennow, Gösta and Strömblad, Lars-Göran and Rosén, Ingmar},
  issn         = {1532-2688},
  keyword      = {spike,EEG,epilepsy,vagus nerve stimulation,detection,children,seizure frequency},
  language     = {eng},
  number       = {8},
  pages        = {527--533},
  publisher    = {Elsevier},
  series       = {Seizure},
  title        = {Long term effects on epileptiform activity with vagus nerve stimulation in children.},
  url          = {http://dx.doi.org/10.1016/j.seizure.2005.07.004},
  volume       = {14},
  year         = {2005},
}