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Influence of androgen receptor repeat polymorphisms on personality traits in men

Westberg, Lars; Henningsson, Susanne; Landen, Mikael; Annerbrink, Kristina; Melke, Jonas; Nilsson, Staffan; Rosmond, Roland; Holm, Goran; Anckarsäter, Henrik LU and Eriksson, Elias (2009) In Journal of Psychiatry & Neuroscience 34(3). p.205-213
Abstract
Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with... (More)
Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations: Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion: Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Psychiatry & Neuroscience
volume
34
issue
3
pages
205 - 213
publisher
Cma-Canadian Medical Assoc
external identifiers
  • wos:000265540400007
  • scopus:67749093321
ISSN
1180-4882
language
English
LU publication?
yes
id
2bc41aff-f28b-4131-8bdf-d499b0f1fd84 (old id 1427894)
date added to LUP
2009-06-25 14:22:36
date last changed
2017-10-22 04:05:50
@article{2bc41aff-f28b-4131-8bdf-d499b0f1fd84,
  abstract     = {Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations: Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion: Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.},
  author       = {Westberg, Lars and Henningsson, Susanne and Landen, Mikael and Annerbrink, Kristina and Melke, Jonas and Nilsson, Staffan and Rosmond, Roland and Holm, Goran and Anckarsäter, Henrik and Eriksson, Elias},
  issn         = {1180-4882},
  language     = {eng},
  number       = {3},
  pages        = {205--213},
  publisher    = {Cma-Canadian Medical Assoc},
  series       = {Journal of Psychiatry & Neuroscience},
  title        = {Influence of androgen receptor repeat polymorphisms on personality traits in men},
  volume       = {34},
  year         = {2009},
}