Influence of androgen receptor repeat polymorphisms on personality traits in men
(2009) In Journal of Psychiatry & Neuroscience 34(3). p.205-213- Abstract
- Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with... (More)
- Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations: Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion: Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1427894
- author
- Westberg, Lars ; Henningsson, Susanne ; Landen, Mikael ; Annerbrink, Kristina ; Melke, Jonas ; Nilsson, Staffan ; Rosmond, Roland ; Holm, Goran ; Anckarsäter, Henrik LU and Eriksson, Elias
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Psychiatry & Neuroscience
- volume
- 34
- issue
- 3
- pages
- 205 - 213
- publisher
- Canadian Medical Association
- external identifiers
-
- wos:000265540400007
- scopus:67749093321
- ISSN
- 1180-4882
- language
- English
- LU publication?
- yes
- id
- 2bc41aff-f28b-4131-8bdf-d499b0f1fd84 (old id 1427894)
- date added to LUP
- 2016-04-01 13:24:07
- date last changed
- 2022-03-13 23:51:48
@article{2bc41aff-f28b-4131-8bdf-d499b0f1fd84,
abstract = {{Background: Testosterone has been attributed importance for various aspects of behaviour. The aim of our study was to investigate the potential influence of 2 functional polymorphisms in the amino terminal of the androgen receptor on personality traits in men. Methods: We assessed and genotyped 141 men born in 1944 recruited from the general population. We used 2 different instruments: the Karolinska Scales of Personality and the Temperament and Character Inventory. For replication, we similarly assessed 63 men recruited from a forensic psychiatry study group. Results: In the population-recruited sample, the lengths of the androgen receptor repeats were associated with neuroticism, extraversion and self-transcendence. The association with extraversion was replicated in the independent sample. Limitations: Our 2 samples differed in size; sample 1 was of moderate size and sample 2 was small. In addition, the homogeneity of sample 1 probably enhanced our ability to detect significant associations between genotype and phenotype. Conclusion: Our results suggest that the repeat polymorphisms in the androgen receptor gene may influence personality traits in men.}},
author = {{Westberg, Lars and Henningsson, Susanne and Landen, Mikael and Annerbrink, Kristina and Melke, Jonas and Nilsson, Staffan and Rosmond, Roland and Holm, Goran and Anckarsäter, Henrik and Eriksson, Elias}},
issn = {{1180-4882}},
language = {{eng}},
number = {{3}},
pages = {{205--213}},
publisher = {{Canadian Medical Association}},
series = {{Journal of Psychiatry & Neuroscience}},
title = {{Influence of androgen receptor repeat polymorphisms on personality traits in men}},
volume = {{34}},
year = {{2009}},
}