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Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery-the influence of external oxytocin

Liedman, Ragner LU ; Hansson, Stefan LU ; Igidbashian, Sarah and Åkerlund, Mats LU (2009) In Gynecological Endocrinology 25(3). p.188-193
Abstract
The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F2 and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.520.37 oxytocin receptor/actin; medianSEM) than those delivered with ongoing labour at term (1.010.34; p=0.015) and those at preterm (1.080.25; p=0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to... (More)
The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F2 and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.520.37 oxytocin receptor/actin; medianSEM) than those delivered with ongoing labour at term (1.010.34; p=0.015) and those at preterm (1.080.25; p=0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to patients receiving oxytocin during labour (p=0.007). These patients had higher oxytocin peptide mRNA levels than those without labour at term (p=0.009). PGF2 receptor mRNA concentrations were 27.803.55, 11.462.87 and 19.545.52 PGF receptor/actin, respectively, for the groups. Women without labour at term had higher concentration than those with labour (p=0.005). Our results suggest that oxytocin, its receptor and the PGF2 receptor are involved in the regulation of labour through a paracrine mechanism. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
oxytocin receptor, oxytocin, mRNA expression, PGF2 receptor, preterm and term delivery, estrogen receptor and, progesterone receptor
in
Gynecological Endocrinology
volume
25
issue
3
pages
188 - 193
publisher
Informa Healthcare
external identifiers
  • wos:000265294400008
  • pmid:19347709
  • scopus:67651235458
ISSN
0951-3590
DOI
10.1080/09513590802573213
language
English
LU publication?
yes
id
5b2b73db-2639-437b-898a-19558959ac1e (old id 1427947)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19347709?dopt=Abstract
date added to LUP
2009-06-25 14:02:08
date last changed
2017-07-30 03:54:53
@article{5b2b73db-2639-437b-898a-19558959ac1e,
  abstract     = {The hormonal system for induction of term and preterm labour is not fully understood. Therefore, we investigated myometrial gene expressions for neurohypophyseal hormones and their receptors, prostaglandin F2 and ovarian steroid receptors in women delivered by Caesarean section. Myometrial tissue for real time PCR was collected from 39 women delivered at term before and after the onset of labour and preterm. Women delivered electively at term had significantly higher oxytocin receptor mRNA expressions (2.520.37 oxytocin receptor/actin; medianSEM) than those delivered with ongoing labour at term (1.010.34; p=0.015) and those at preterm (1.080.25; p=0.004). Sub-analyses revealed that the difference at term pregnancies solely was related to patients receiving oxytocin during labour (p=0.007). These patients had higher oxytocin peptide mRNA levels than those without labour at term (p=0.009). PGF2 receptor mRNA concentrations were 27.803.55, 11.462.87 and 19.545.52 PGF receptor/actin, respectively, for the groups. Women without labour at term had higher concentration than those with labour (p=0.005). Our results suggest that oxytocin, its receptor and the PGF2 receptor are involved in the regulation of labour through a paracrine mechanism.},
  author       = {Liedman, Ragner and Hansson, Stefan and Igidbashian, Sarah and Åkerlund, Mats},
  issn         = {0951-3590},
  keyword      = {oxytocin receptor,oxytocin,mRNA expression,PGF2 receptor,preterm and term delivery,estrogen receptor and,progesterone receptor},
  language     = {eng},
  number       = {3},
  pages        = {188--193},
  publisher    = {Informa Healthcare},
  series       = {Gynecological Endocrinology},
  title        = {Myometrial oxytocin receptor mRNA concentrations at preterm and term delivery-the influence of external oxytocin},
  url          = {http://dx.doi.org/10.1080/09513590802573213},
  volume       = {25},
  year         = {2009},
}