Early identification of acute myocardial infarction by activated protein C-protein C inhibitor complex.
(2006) In Thrombosis Research 118(Aug 10). p.213-219- Abstract
- Introduction: Increased coagulation activity due to coronary thrombosis in a ruptured plaque should result in activation of the protein C anticoagulant system with formation of complexes between activated protein C (APC) and,the protein C inhibitor (PCI), which reflects coagulation activity. We hypothesized that elevated APC-PCI concentration might allow earlier detection of ongoing myocardial infarction than traditional biochemical markers. We have evaluated a newly devised immunofluorimetric assay for measuring plasma concentration of APC-PCI complexes among patients with suspected acute coronary syndrome. Materials and methods: Blood samples were taken from 340 patients (median 71 years, range 31-97) with suspected acute coronary... (More)
- Introduction: Increased coagulation activity due to coronary thrombosis in a ruptured plaque should result in activation of the protein C anticoagulant system with formation of complexes between activated protein C (APC) and,the protein C inhibitor (PCI), which reflects coagulation activity. We hypothesized that elevated APC-PCI concentration might allow earlier detection of ongoing myocardial infarction than traditional biochemical markers. We have evaluated a newly devised immunofluorimetric assay for measuring plasma concentration of APC-PCI complexes among patients with suspected acute coronary syndrome. Materials and methods: Blood samples were taken from 340 patients (median 71 years, range 31-97) with suspected acute coronary syndrome at first presentation in the emergency department. Electrocardiogram was recorded and APC PCI, Troponin I and Creatine kinase-MB concentrations were repeatedly measured 3 times at 6 h interval. Results: The 74 patients who were eventually diagnosed with myocardial infarction had a higher median level of APC-PCI complex than those Without myocardial damage; 0.27 vs. 0.20 mu g/L (p = 0.001). In a multivariate regression model, APC-PCI level in the fourth quartile (> 0.32 mu g/L) independently predicted myocardial infarction with an odds ratio of 3.7 (95% CI 1.4-9.6, p < 0.01). Conclusion: Early APC-PCI elevation can be detected among patients with a normal first Troponin I and non-ST-elevation myocardial infarction and provides additional risk assessment in acute coronary syndrome. (c) 2005 Published by Elsevier Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/142799
- author
- Bhiladvala, Pallonji LU ; Strandberg, Karin LU ; Stenflo, Johan LU and Holm, Johan LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- protein C inhibitor, myocardial infarction, coagulation activity, activated protein C
- in
- Thrombosis Research
- volume
- 118
- issue
- Aug 10
- pages
- 213 - 219
- publisher
- Elsevier
- external identifiers
-
- pmid:16098566
- wos:000238790800007
- scopus:33744533523
- pmid:16098566
- ISSN
- 1879-2472
- DOI
- 10.1016/j.thromres.2005.06.020
- language
- English
- LU publication?
- yes
- id
- 11a3db3f-b08f-4c45-8f89-910c66f56bc5 (old id 142799)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16098566&dopt=Abstract
- date added to LUP
- 2016-04-01 11:56:10
- date last changed
- 2022-01-26 20:27:12
@article{11a3db3f-b08f-4c45-8f89-910c66f56bc5, abstract = {{Introduction: Increased coagulation activity due to coronary thrombosis in a ruptured plaque should result in activation of the protein C anticoagulant system with formation of complexes between activated protein C (APC) and,the protein C inhibitor (PCI), which reflects coagulation activity. We hypothesized that elevated APC-PCI concentration might allow earlier detection of ongoing myocardial infarction than traditional biochemical markers. We have evaluated a newly devised immunofluorimetric assay for measuring plasma concentration of APC-PCI complexes among patients with suspected acute coronary syndrome. Materials and methods: Blood samples were taken from 340 patients (median 71 years, range 31-97) with suspected acute coronary syndrome at first presentation in the emergency department. Electrocardiogram was recorded and APC PCI, Troponin I and Creatine kinase-MB concentrations were repeatedly measured 3 times at 6 h interval. Results: The 74 patients who were eventually diagnosed with myocardial infarction had a higher median level of APC-PCI complex than those Without myocardial damage; 0.27 vs. 0.20 mu g/L (p = 0.001). In a multivariate regression model, APC-PCI level in the fourth quartile (> 0.32 mu g/L) independently predicted myocardial infarction with an odds ratio of 3.7 (95% CI 1.4-9.6, p < 0.01). Conclusion: Early APC-PCI elevation can be detected among patients with a normal first Troponin I and non-ST-elevation myocardial infarction and provides additional risk assessment in acute coronary syndrome. (c) 2005 Published by Elsevier Ltd.}}, author = {{Bhiladvala, Pallonji and Strandberg, Karin and Stenflo, Johan and Holm, Johan}}, issn = {{1879-2472}}, keywords = {{protein C inhibitor; myocardial infarction; coagulation activity; activated protein C}}, language = {{eng}}, number = {{Aug 10}}, pages = {{213--219}}, publisher = {{Elsevier}}, series = {{Thrombosis Research}}, title = {{Early identification of acute myocardial infarction by activated protein C-protein C inhibitor complex.}}, url = {{http://dx.doi.org/10.1016/j.thromres.2005.06.020}}, doi = {{10.1016/j.thromres.2005.06.020}}, volume = {{118}}, year = {{2006}}, }