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Proposed core set of outcome measures in patients with primary Sjögren's syndrome: 5 year follow up.

Theander, Elke LU ; Andersson, Sven Ingmar LU ; Manthorpe, Rolf LU and Jacobsson, Lennart LU (2005) In Journal of Rheumatology 32(8). p.1495-1502
Abstract
Objective. To clarify the spontaneous course of important disease manifestations (a core set of outcome measures) over a period of 5 years in patients with primary Sjögren's syndrome (SS), and to analyze predictors of unfavorable outcome. To test the usefulness of the recently proposed core set of outcome measures.



Methods. A cohort of patients with primary SS according to the American-European consensus criteria (AECC) (n = 58) was followed over a period of 5 years. Measures for subjective and objective disease characteristics, IgG concentrations and health related quality of life were analyzed on 2 occasions and compared.



Results. During followup, symptoms of dry eyes, dry mouth, fatigue, and health... (More)
Objective. To clarify the spontaneous course of important disease manifestations (a core set of outcome measures) over a period of 5 years in patients with primary Sjögren's syndrome (SS), and to analyze predictors of unfavorable outcome. To test the usefulness of the recently proposed core set of outcome measures.



Methods. A cohort of patients with primary SS according to the American-European consensus criteria (AECC) (n = 58) was followed over a period of 5 years. Measures for subjective and objective disease characteristics, IgG concentrations and health related quality of life were analyzed on 2 occasions and compared.



Results. During followup, symptoms of dry eyes, dry mouth, fatigue, and health related quality of life were stable. Regarding objective signs, there was a modest but statistically significant worsening of the van Bijsterveld score. Seropositivity for anti-SSA and low complement levels predicted further decline in the van Bijsterveld score. Floor/ceiling effects in the outcome measures in the core set complicate documentation of further decline, but may allow monitoring of improvement in established primary SS.



Conclusion. Primary SS, if classified according to the strict AECC criteria, is a bothersome and slowly progressive disease, with fatigue and discomfort developing early. The proposed outcome measures may be suitable for assessing improvement in randomized controlled trials. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Rheumatology
volume
32
issue
8
pages
1495 - 1502
publisher
J Rheumatol Publ Co
external identifiers
  • pmid:16078325
  • wos:000231103100014
ISSN
0315-162X
language
English
LU publication?
yes
id
2547b2c3-42d7-495c-b6e2-55a247d3b6e3 (old id 142986)
alternative location
http://www.jrheum.com/subscribers/05/08/1495.html
date added to LUP
2007-06-25 16:41:11
date last changed
2016-04-15 19:38:53
@article{2547b2c3-42d7-495c-b6e2-55a247d3b6e3,
  abstract     = {Objective. To clarify the spontaneous course of important disease manifestations (a core set of outcome measures) over a period of 5 years in patients with primary Sjögren's syndrome (SS), and to analyze predictors of unfavorable outcome. To test the usefulness of the recently proposed core set of outcome measures.<br/><br>
<br/><br>
Methods. A cohort of patients with primary SS according to the American-European consensus criteria (AECC) (n = 58) was followed over a period of 5 years. Measures for subjective and objective disease characteristics, IgG concentrations and health related quality of life were analyzed on 2 occasions and compared.<br/><br>
<br/><br>
Results. During followup, symptoms of dry eyes, dry mouth, fatigue, and health related quality of life were stable. Regarding objective signs, there was a modest but statistically significant worsening of the van Bijsterveld score. Seropositivity for anti-SSA and low complement levels predicted further decline in the van Bijsterveld score. Floor/ceiling effects in the outcome measures in the core set complicate documentation of further decline, but may allow monitoring of improvement in established primary SS.<br/><br>
<br/><br>
Conclusion. Primary SS, if classified according to the strict AECC criteria, is a bothersome and slowly progressive disease, with fatigue and discomfort developing early. The proposed outcome measures may be suitable for assessing improvement in randomized controlled trials.},
  author       = {Theander, Elke and Andersson, Sven Ingmar and Manthorpe, Rolf and Jacobsson, Lennart},
  issn         = {0315-162X},
  language     = {eng},
  number       = {8},
  pages        = {1495--1502},
  publisher    = {J Rheumatol Publ Co},
  series       = {Journal of Rheumatology},
  title        = {Proposed core set of outcome measures in patients with primary Sjögren's syndrome: 5 year follow up.},
  volume       = {32},
  year         = {2005},
}