Prevalence and incidence of HIV-1 and HIV-2 before, during and after a civil war in an occupational cohort in Guinea-Bissau, West Africa.
(2009) In AIDS 23. p.1575-1582- Abstract
- OBJECTIVES:: To study prevalence and incidence of HIV-1 and HIV-2 between 1990 and 2007 and to examine impact of the civil war in 1998-1999. We also wanted to investigate possible interaction between HIV-1 and HIV-2. DESIGN:: Open prospective cohort study of 4592 police officers in Guinea-Bissau, West Africa. METHODS:: Analysis of HIV-1 and HIV-2 prevalence and incidence divided in 2-3 years time strata. RESULTS:: HIV-1 prevalence (including HIV-1/HIV-2 dual reactivity) increased gradually from 0.6 to 3.6% before the war and was 9.5% in the first serosurvey after the war. HIV-1 incidence more than doubled during and shortly after the war, from 0.50 to 1.22 per 100 person-years. Both prevalence and incidence of HIV-1 decreased in the... (More)
- OBJECTIVES:: To study prevalence and incidence of HIV-1 and HIV-2 between 1990 and 2007 and to examine impact of the civil war in 1998-1999. We also wanted to investigate possible interaction between HIV-1 and HIV-2. DESIGN:: Open prospective cohort study of 4592 police officers in Guinea-Bissau, West Africa. METHODS:: Analysis of HIV-1 and HIV-2 prevalence and incidence divided in 2-3 years time strata. RESULTS:: HIV-1 prevalence (including HIV-1/HIV-2 dual reactivity) increased gradually from 0.6 to 3.6% before the war and was 9.5% in the first serosurvey after the war. HIV-1 incidence more than doubled during and shortly after the war, from 0.50 to 1.22 per 100 person-years. Both prevalence and incidence of HIV-1 decreased in the following periods after the war. HIV-2 prevalence decreased from 13.4 to 6.2% during the entire study period and HIV-2 incidence decreased from 1.38 to 0.18 per 100 person-years. Adjusted incidence rate ratios of HIV-1 incidence in HIV-2-positive participants compared with HIV-negative participants ranged from 1.02 to 1.18 (not significant) depending on the confounding variables included. CONCLUSION:: HIV-1 has increased, whereas HIV-2 has decreased and the risk of acquiring HIV-1 is now more than four times higher as compared with HIV-2. The civil war in 1998-1999 appears to have induced a temporary increase in HIV-1 transmission, but now a stabilization of HIV-1 incidence and prevalence seems to have taken place. There was no evidence of a protective effect of HIV-2 against HIV-1 infection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1434279
- author
- Månsson, Fredrik LU ; Biague, Antonio ; da Silva, Zacarias ; Dias, Francisco ; Nilsson, LA ; Andersson, Sören ; Fenyö, Eva Maria LU and Norrgren, Hans LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- AIDS
- volume
- 23
- pages
- 1575 - 1582
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000268414300016
- pmid:19521234
- scopus:68649099264
- pmid:19521234
- ISSN
- 1473-5571
- DOI
- 10.1097/QAD.0b013e32832cedfb
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Infectious Diseases Research Unit (013242010), Division of Infection Medicine (SUS) (013008000), Division of Medical Microbiology (013250400)
- id
- 1b100fc9-f86a-443f-b3b1-bae04e325a78 (old id 1434279)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19521234?dopt=Abstract
- date added to LUP
- 2016-04-04 07:42:43
- date last changed
- 2022-01-29 02:32:47
@article{1b100fc9-f86a-443f-b3b1-bae04e325a78, abstract = {{OBJECTIVES:: To study prevalence and incidence of HIV-1 and HIV-2 between 1990 and 2007 and to examine impact of the civil war in 1998-1999. We also wanted to investigate possible interaction between HIV-1 and HIV-2. DESIGN:: Open prospective cohort study of 4592 police officers in Guinea-Bissau, West Africa. METHODS:: Analysis of HIV-1 and HIV-2 prevalence and incidence divided in 2-3 years time strata. RESULTS:: HIV-1 prevalence (including HIV-1/HIV-2 dual reactivity) increased gradually from 0.6 to 3.6% before the war and was 9.5% in the first serosurvey after the war. HIV-1 incidence more than doubled during and shortly after the war, from 0.50 to 1.22 per 100 person-years. Both prevalence and incidence of HIV-1 decreased in the following periods after the war. HIV-2 prevalence decreased from 13.4 to 6.2% during the entire study period and HIV-2 incidence decreased from 1.38 to 0.18 per 100 person-years. Adjusted incidence rate ratios of HIV-1 incidence in HIV-2-positive participants compared with HIV-negative participants ranged from 1.02 to 1.18 (not significant) depending on the confounding variables included. CONCLUSION:: HIV-1 has increased, whereas HIV-2 has decreased and the risk of acquiring HIV-1 is now more than four times higher as compared with HIV-2. The civil war in 1998-1999 appears to have induced a temporary increase in HIV-1 transmission, but now a stabilization of HIV-1 incidence and prevalence seems to have taken place. There was no evidence of a protective effect of HIV-2 against HIV-1 infection.}}, author = {{Månsson, Fredrik and Biague, Antonio and da Silva, Zacarias and Dias, Francisco and Nilsson, LA and Andersson, Sören and Fenyö, Eva Maria and Norrgren, Hans}}, issn = {{1473-5571}}, language = {{eng}}, pages = {{1575--1582}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{AIDS}}, title = {{Prevalence and incidence of HIV-1 and HIV-2 before, during and after a civil war in an occupational cohort in Guinea-Bissau, West Africa.}}, url = {{http://dx.doi.org/10.1097/QAD.0b013e32832cedfb}}, doi = {{10.1097/QAD.0b013e32832cedfb}}, volume = {{23}}, year = {{2009}}, }