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Clinical utility of HPV-DNA detection: Triage of minor cervical lesions, follow-up of women treated for high-grade CIN: An update of pooled evidence.

Arbyn, M; Paraskevaidis, E; Martin-Hirsh, P; Prendiville, W and Dillner, Joakim LU (2005) In Gynecologic Oncology 99(3, Suppl 1). p.7-11
Abstract
Objective. Human papilloma virus (HPV) testing and repeat cytology are both proposed as methods to triage women with minor cytological cervical lesions. By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy. Methods. We conducted meta-analyses of reported studies on the accuracy to detect high-grade cervical intra-epithelial neoplasia or worse disease (CIN2+) in women with ASCUS or LSIL. We also performed meta-analyses to examine the best predictor of recurrence of CIN after treatment for CIN2 or CIN3. Results. We found that HPV testing using the Hybrid Capture II test is more effective (more sensitive, equally specific) than cytology for the triage of patients with ASCUS Pap... (More)
Objective. Human papilloma virus (HPV) testing and repeat cytology are both proposed as methods to triage women with minor cytological cervical lesions. By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy. Methods. We conducted meta-analyses of reported studies on the accuracy to detect high-grade cervical intra-epithelial neoplasia or worse disease (CIN2+) in women with ASCUS or LSIL. We also performed meta-analyses to examine the best predictor of recurrence of CIN after treatment for CIN2 or CIN3. Results. We found that HPV testing using the Hybrid Capture II test is more effective (more sensitive, equally specific) than cytology for the triage of patients with ASCUS Pap smears. Because of the high rate of HPV positivity, this is not the case for patients with LSIL. Studies concerning post-treatment follow-Lip were heterogeneous. In general, HPV testing performed better than follow-up cytology to predict success or failure of treatment (significantly higher sensitivity, not significantly lower specificity). Conclusions. Overall, in comparison with follow-up cytology, HPV DNA testing is more sensitive and equally specific for triage of ASCUS cases and for predicting recurrence of CIN in women treated for high-grade CIN. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
LSIL, triage, HPV DNA, cervical cancer, human papillomavirus, follow-up after treatment, meta-analysis, ASCUS
in
Gynecologic Oncology
volume
99
issue
3, Suppl 1
pages
7 - 11
publisher
Academic Press
external identifiers
  • pmid:16154623
  • wos:000234502500003
  • scopus:28844508294
ISSN
1095-6859
DOI
10.1016/j.ygyno.2005.07.033
language
English
LU publication?
yes
id
f137f1ea-b9f3-4181-b48d-8e38dc695d8d (old id 143733)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16154623&dopt=Abstract
date added to LUP
2007-07-24 11:07:21
date last changed
2017-11-12 03:19:19
@article{f137f1ea-b9f3-4181-b48d-8e38dc695d8d,
  abstract     = {Objective. Human papilloma virus (HPV) testing and repeat cytology are both proposed as methods to triage women with minor cytological cervical lesions. By triage, those women can be identified who need referral for diagnostic exploration with colposcopy and/or biopsy. Methods. We conducted meta-analyses of reported studies on the accuracy to detect high-grade cervical intra-epithelial neoplasia or worse disease (CIN2+) in women with ASCUS or LSIL. We also performed meta-analyses to examine the best predictor of recurrence of CIN after treatment for CIN2 or CIN3. Results. We found that HPV testing using the Hybrid Capture II test is more effective (more sensitive, equally specific) than cytology for the triage of patients with ASCUS Pap smears. Because of the high rate of HPV positivity, this is not the case for patients with LSIL. Studies concerning post-treatment follow-Lip were heterogeneous. In general, HPV testing performed better than follow-up cytology to predict success or failure of treatment (significantly higher sensitivity, not significantly lower specificity). Conclusions. Overall, in comparison with follow-up cytology, HPV DNA testing is more sensitive and equally specific for triage of ASCUS cases and for predicting recurrence of CIN in women treated for high-grade CIN.},
  author       = {Arbyn, M and Paraskevaidis, E and Martin-Hirsh, P and Prendiville, W and Dillner, Joakim},
  issn         = {1095-6859},
  keyword      = {LSIL,triage,HPV DNA,cervical cancer,human papillomavirus,follow-up after treatment,meta-analysis,ASCUS},
  language     = {eng},
  number       = {3, Suppl 1},
  pages        = {7--11},
  publisher    = {Academic Press},
  series       = {Gynecologic Oncology},
  title        = {Clinical utility of HPV-DNA detection: Triage of minor cervical lesions, follow-up of women treated for high-grade CIN: An update of pooled evidence.},
  url          = {http://dx.doi.org/10.1016/j.ygyno.2005.07.033},
  volume       = {99},
  year         = {2005},
}