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The PPARGC1A Gly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men

Ingelsson, Erik; Bennet, Louise LU ; Ridderstrale, Martin; Soderstrom, Marianne; Rastam, Lennart and Lindblad, Ulf (2008) In BMC Cardiovascular Disorders 8(37).
Abstract
Background: The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction. Methods: The PPARGC1A Gly482Ser polymorphism was genotyped in a community-based cohort of 499 men and 533 women, who also underwent an echocardiographic examination to determine their left ventricular diastolic function. The association between the polymorphism and the presence of diastolic dysfunction was evaluated using logistic regression models. Results: The Ser allele of the PPARGC1A Gly482Ser polymorphism was significantly associated with a lower risk... (More)
Background: The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction. Methods: The PPARGC1A Gly482Ser polymorphism was genotyped in a community-based cohort of 499 men and 533 women, who also underwent an echocardiographic examination to determine their left ventricular diastolic function. The association between the polymorphism and the presence of diastolic dysfunction was evaluated using logistic regression models. Results: The Ser allele of the PPARGC1A Gly482Ser polymorphism was significantly associated with a lower risk of diastolic dysfunction in men, but not in women. In a model adjusting for potential confounders (age, body mass index, leisure time physical activity, hypertension and diabetes) the results were still significant and substantial (odds ratio 0.13, 95% confidence interval 0.03-0.54, p for trend =0.004). The results were consistent in a series of models, and they imply a multiplicative, protective effect of the Ser allele, with lower risk of diastolic dysfunction for each copy of the allele. Conclusion: The Ser allele of the PPARGC1A Gly482Ser polymorphism was associated with decreased risk of diastolic left ventricular dysfunction in men, but not in women, in our large community-based sample. It was associated with a substantially decreased risk, even after adjustment for potential confounders. The clinical importance of the findings has to be established in further studies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Cardiovascular Disorders
volume
8
issue
37
publisher
BioMed Central
external identifiers
  • wos:000266881200001
  • scopus:60849124818
ISSN
1471-2261
DOI
10.1186/1471-2261-8-37
language
English
LU publication?
yes
id
23f266c3-9dc5-4dc0-8002-57c88bb6bd55 (old id 1440515)
date added to LUP
2009-07-27 16:50:18
date last changed
2017-01-01 06:27:31
@article{23f266c3-9dc5-4dc0-8002-57c88bb6bd55,
  abstract     = {Background: The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction. Methods: The PPARGC1A Gly482Ser polymorphism was genotyped in a community-based cohort of 499 men and 533 women, who also underwent an echocardiographic examination to determine their left ventricular diastolic function. The association between the polymorphism and the presence of diastolic dysfunction was evaluated using logistic regression models. Results: The Ser allele of the PPARGC1A Gly482Ser polymorphism was significantly associated with a lower risk of diastolic dysfunction in men, but not in women. In a model adjusting for potential confounders (age, body mass index, leisure time physical activity, hypertension and diabetes) the results were still significant and substantial (odds ratio 0.13, 95% confidence interval 0.03-0.54, p for trend =0.004). The results were consistent in a series of models, and they imply a multiplicative, protective effect of the Ser allele, with lower risk of diastolic dysfunction for each copy of the allele. Conclusion: The Ser allele of the PPARGC1A Gly482Ser polymorphism was associated with decreased risk of diastolic left ventricular dysfunction in men, but not in women, in our large community-based sample. It was associated with a substantially decreased risk, even after adjustment for potential confounders. The clinical importance of the findings has to be established in further studies.},
  author       = {Ingelsson, Erik and Bennet, Louise and Ridderstrale, Martin and Soderstrom, Marianne and Rastam, Lennart and Lindblad, Ulf},
  issn         = {1471-2261},
  language     = {eng},
  number       = {37},
  publisher    = {BioMed Central},
  series       = {BMC Cardiovascular Disorders},
  title        = {The PPARGC1A Gly482Ser polymorphism is associated with left ventricular diastolic dysfunction in men},
  url          = {http://dx.doi.org/10.1186/1471-2261-8-37},
  volume       = {8},
  year         = {2008},
}