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The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects

Choquet, Helene; Cavalcanti-Proenca, Christine; Lecoeur, Cecile; Dina, Christian; Cauchi, Stephane; Vaxillaire, Martine; Hadjadj, Samy; Horber, Fritz; Potoczna, Natasha and Charpentier, Guillaume, et al. (2009) In Human Molecular Genetics 18(13). p.2495-2501
Abstract
A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for... (More)
A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for protection against T2D [OR = 0.86 (0.80-0.92), P = 1.4 x 10(-5)]. Potential confounders such as gender, age, obesity status or family history were tested in 4335 T2D and 4179 normoglycemic subjects and they had no influence on T2D risk. This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes. (Less)
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publication status
published
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Human Molecular Genetics
volume
18
issue
13
pages
2495 - 2501
publisher
Oxford University Press
external identifiers
  • wos:000266961400016
  • scopus:67449098254
ISSN
0964-6906
DOI
10.1093/hmg/ddp169
language
English
LU publication?
yes
id
67c09f43-d68f-4df3-b04c-4cb0279a3314 (old id 1442072)
date added to LUP
2009-07-27 13:39:21
date last changed
2017-12-10 03:45:14
@article{67c09f43-d68f-4df3-b04c-4cb0279a3314,
  abstract     = {A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D). As replication in several studies is mandatory to confirm genetic results, we analyzed the T-381C polymorphism in seven independent case-control cohorts and in 291 T2D-enriched pedigrees totalling 39 557 subjects of European origin. A meta-analysis of the seven case-control studies (n = 39 040) showed a nominal protective effect [odds ratio (OR) = 0.86 (0.79-0.94), P = 0.0006] of the CC genotype on T2D risk, consistent with the previous study. By combining all available data (n = 49 279), we further confirmed a modest contribution of the BNP T-381C polymorphism for protection against T2D [OR = 0.86 (0.80-0.92), P = 1.4 x 10(-5)]. Potential confounders such as gender, age, obesity status or family history were tested in 4335 T2D and 4179 normoglycemic subjects and they had no influence on T2D risk. This study provides further evidence of a modest contribution of the BNP T-381C polymorphism in protection against T2D and illustrates the difficulty of unambiguously proving modest-sized associations even with large sample sizes.},
  author       = {Choquet, Helene and Cavalcanti-Proenca, Christine and Lecoeur, Cecile and Dina, Christian and Cauchi, Stephane and Vaxillaire, Martine and Hadjadj, Samy and Horber, Fritz and Potoczna, Natasha and Charpentier, Guillaume and Ruiz, Juan and Hercberg, Serge and Maimaitiming, Suliya and Roussel, Ronan and Boenhnke, Michael and Jackson, Anne U. and Patsch, Wolfgang and Krempler, Franz and Voight, Benjamin F. and Altshuler, David and Groop, Leif and Thorleifsson, Gudmar and Steinthorsdottir, Valgerdur and Stefansson, Kari and Balkau, Beverley and Froguel, Philippe and Meyre, David},
  issn         = {0964-6906},
  language     = {eng},
  number       = {13},
  pages        = {2495--2501},
  publisher    = {Oxford University Press},
  series       = {Human Molecular Genetics},
  title        = {The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects},
  url          = {http://dx.doi.org/10.1093/hmg/ddp169},
  volume       = {18},
  year         = {2009},
}