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Insignificant Prostate Cancer and Active Surveillance: From Definition to Clinical Implications

Bastian, Patrick J.; Carter, Ballentine H.; Bjartell, Anders LU ; Seitz, Michael; Stanislaus, Peter; Montorsi, Francesco; Stief, Christian G. and Schroeder, Fritz (2009) In European Urology 55(6). p.1321-1332
Abstract
Context: Due to early detection strategies, prostate cancer is diagnosed early in its natural history. It remains unclear whether all patients diagnosed with prostate cancer warrant radical treatment or may benefit from delayed intervention following active surveillance. Objective: A systematic review of active surveillance protocols to investigate the inclusion criteria for active surveillance and the outcome of treatment. Evidence acquisition: Medline was searched using the following terms: prostate cancer, active surveillance and expectant management for dates up to October 2008. Further studies were chosen on the basis of manual searches of reference lists and review papers. Evidence synthesis: Numerous studies on active surveillance... (More)
Context: Due to early detection strategies, prostate cancer is diagnosed early in its natural history. It remains unclear whether all patients diagnosed with prostate cancer warrant radical treatment or may benefit from delayed intervention following active surveillance. Objective: A systematic review of active surveillance protocols to investigate the inclusion criteria for active surveillance and the outcome of treatment. Evidence acquisition: Medline was searched using the following terms: prostate cancer, active surveillance and expectant management for dates up to October 2008. Further studies were chosen on the basis of manual searches of reference lists and review papers. Evidence synthesis: Numerous studies on active surveillance were identified. The recent inclusion criteria of the studies are rather similar. Keeping the short follow-up of all studies in mind, the majority of men stay on active surveillance, and the percentage of patients receiving active treatment is as high as 35% of all patients. Once a patients requires active treatment, most patients still present with curable prostate cancer. Furthermore, only few deaths due to prostate cancer have occurred. Conclusions: Active surveillance is an alternative option to immediate treatment of men with presumed insignificant prostate cancer. It seems that criteria used to identify men with low-risk prostate cancer are rather similar, and immediate treatment of men meeting these criteria may result in an unnecessary number of treatments in these highly selected patients. Data from randomised trials comparing active surveillance and active treatment will provide additional insight into outcome and follow-up strategies. (C) 2009 Published by Elsevier B.V. on behalf of European Association of Urology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Prostate cancer, Active surveillance, Watchful waiting, Insignificant, Low risk prostate cancer, prostate cancer
in
European Urology
volume
55
issue
6
pages
1321 - 1332
publisher
Elsevier
external identifiers
  • wos:000266769700016
  • scopus:65049084253
ISSN
1873-7560
DOI
10.1016/j.eururo.2009.02.028
language
English
LU publication?
yes
id
0e540ad5-f6c2-4d80-b650-eb91fd9cc784 (old id 1442269)
date added to LUP
2009-07-27 10:53:41
date last changed
2017-12-10 04:20:04
@article{0e540ad5-f6c2-4d80-b650-eb91fd9cc784,
  abstract     = {Context: Due to early detection strategies, prostate cancer is diagnosed early in its natural history. It remains unclear whether all patients diagnosed with prostate cancer warrant radical treatment or may benefit from delayed intervention following active surveillance. Objective: A systematic review of active surveillance protocols to investigate the inclusion criteria for active surveillance and the outcome of treatment. Evidence acquisition: Medline was searched using the following terms: prostate cancer, active surveillance and expectant management for dates up to October 2008. Further studies were chosen on the basis of manual searches of reference lists and review papers. Evidence synthesis: Numerous studies on active surveillance were identified. The recent inclusion criteria of the studies are rather similar. Keeping the short follow-up of all studies in mind, the majority of men stay on active surveillance, and the percentage of patients receiving active treatment is as high as 35% of all patients. Once a patients requires active treatment, most patients still present with curable prostate cancer. Furthermore, only few deaths due to prostate cancer have occurred. Conclusions: Active surveillance is an alternative option to immediate treatment of men with presumed insignificant prostate cancer. It seems that criteria used to identify men with low-risk prostate cancer are rather similar, and immediate treatment of men meeting these criteria may result in an unnecessary number of treatments in these highly selected patients. Data from randomised trials comparing active surveillance and active treatment will provide additional insight into outcome and follow-up strategies. (C) 2009 Published by Elsevier B.V. on behalf of European Association of Urology.},
  author       = {Bastian, Patrick J. and Carter, Ballentine H. and Bjartell, Anders and Seitz, Michael and Stanislaus, Peter and Montorsi, Francesco and Stief, Christian G. and Schroeder, Fritz},
  issn         = {1873-7560},
  keyword      = {Prostate cancer,Active surveillance,Watchful waiting,Insignificant,Low risk prostate cancer,prostate cancer},
  language     = {eng},
  number       = {6},
  pages        = {1321--1332},
  publisher    = {Elsevier},
  series       = {European Urology},
  title        = {Insignificant Prostate Cancer and Active Surveillance: From Definition to Clinical Implications},
  url          = {http://dx.doi.org/10.1016/j.eururo.2009.02.028},
  volume       = {55},
  year         = {2009},
}