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Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants

Lennestal, Roland; Olausson, Petra Otterblad and Källén, Bengt LU (2009) In European Journal of Clinical Pharmacology 65(6). p.615-625
Abstract
Purpose To investigate the association between maternal use of antihypertensives in early pregnancy and delivery outcome, notably infant congenital malformations. Methods A cohort study of 1,418 women who had used antihypertensive drugs in early pregnancy but had no diabetes diagnosis were identified from the Swedish Medical Birth Register. Results There was an excess risk for placental abruption, caesarean section, delivery induction, and post-delivery hemorrhage in women taking hypertensives. Infants were more often than expected born preterm, were small for gestational age, and had an excess of various neonatal symptoms. Cardiovascular defects occurred with an adjusted odds ratio of 2.59 (95% CI 1.92-3.51). The results were similar when... (More)
Purpose To investigate the association between maternal use of antihypertensives in early pregnancy and delivery outcome, notably infant congenital malformations. Methods A cohort study of 1,418 women who had used antihypertensive drugs in early pregnancy but had no diabetes diagnosis were identified from the Swedish Medical Birth Register. Results There was an excess risk for placental abruption, caesarean section, delivery induction, and post-delivery hemorrhage in women taking hypertensives. Infants were more often than expected born preterm, were small for gestational age, and had an excess of various neonatal symptoms. Cardiovascular defects occurred with an adjusted odds ratio of 2.59 (95% CI 1.92-3.51). The results were similar when the woman had used ACE inhibitors or other antihypertensives, notably beta blockers. Stillbirth rate was increased (risk ratio 1.87, 95% CI 1.02-3.02), again without any clear drug specificity. Conclusions There seems to be little drug specificity in the association between maternal use of antihypertensives and an increased risk for infant cardiovascular defects. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antihypertensives, Beta-blocking agents, Cardiovascular, defects, Stillbirths, Congenital malformations, ACE inhibitors
in
European Journal of Clinical Pharmacology
volume
65
issue
6
pages
615 - 625
publisher
Springer
external identifiers
  • wos:000266886000010
  • scopus:68849090817
ISSN
1432-1041
DOI
10.1007/s00228-009-0620-0
language
English
LU publication?
yes
id
07ba659e-8d49-48ea-b02d-bca27842e124 (old id 1442279)
date added to LUP
2009-07-27 10:55:18
date last changed
2017-11-19 03:50:19
@article{07ba659e-8d49-48ea-b02d-bca27842e124,
  abstract     = {Purpose To investigate the association between maternal use of antihypertensives in early pregnancy and delivery outcome, notably infant congenital malformations. Methods A cohort study of 1,418 women who had used antihypertensive drugs in early pregnancy but had no diabetes diagnosis were identified from the Swedish Medical Birth Register. Results There was an excess risk for placental abruption, caesarean section, delivery induction, and post-delivery hemorrhage in women taking hypertensives. Infants were more often than expected born preterm, were small for gestational age, and had an excess of various neonatal symptoms. Cardiovascular defects occurred with an adjusted odds ratio of 2.59 (95% CI 1.92-3.51). The results were similar when the woman had used ACE inhibitors or other antihypertensives, notably beta blockers. Stillbirth rate was increased (risk ratio 1.87, 95% CI 1.02-3.02), again without any clear drug specificity. Conclusions There seems to be little drug specificity in the association between maternal use of antihypertensives and an increased risk for infant cardiovascular defects.},
  author       = {Lennestal, Roland and Olausson, Petra Otterblad and Källén, Bengt},
  issn         = {1432-1041},
  keyword      = {Antihypertensives,Beta-blocking agents,Cardiovascular,defects,Stillbirths,Congenital malformations,ACE inhibitors},
  language     = {eng},
  number       = {6},
  pages        = {615--625},
  publisher    = {Springer},
  series       = {European Journal of Clinical Pharmacology},
  title        = {Maternal use of antihypertensive drugs in early pregnancy and delivery outcome, notably the presence of congenital heart defects in the infants},
  url          = {http://dx.doi.org/10.1007/s00228-009-0620-0},
  volume       = {65},
  year         = {2009},
}