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Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men

Marsell, R.; Mirza, M. A. I.; Mallmin, H.; Karlsson, Magnus LU ; Mellstrom, D.; Orwoll, E.; Ohlsson, C.; Jonsson, K. B.; Ljunggren, O. and Larsson, T. E. (2009) In Osteoporosis International 20(7). p.1167-1173
Abstract
We evaluated the relation between serum FGF23 and bone mineral density (BMD) in a community-based cohort of elderly men. There was a weak correlation between FGF23 and BMD, which was primarily dependent on body weight. FGF23 is a hormonal factor produced in bone and regulates serum levels of phosphate (Pi) and vitamin D. FGF23 over-expression is associated with skeletal abnormalities, including rickets/osteomalacia. The relation between FGF23 and Bone Mineral Density (BMD) in the community remains unexplored. We employed a large, population-based cohort of 3014 Swedish men aged 69-80 years, without known renal disease. BMD was measured with dual X-ray absorptiometry (DXA) in the hip and lumbar spine. Serum intact FGF23 was analyzed with a... (More)
We evaluated the relation between serum FGF23 and bone mineral density (BMD) in a community-based cohort of elderly men. There was a weak correlation between FGF23 and BMD, which was primarily dependent on body weight. FGF23 is a hormonal factor produced in bone and regulates serum levels of phosphate (Pi) and vitamin D. FGF23 over-expression is associated with skeletal abnormalities, including rickets/osteomalacia. The relation between FGF23 and Bone Mineral Density (BMD) in the community remains unexplored. We employed a large, population-based cohort of 3014 Swedish men aged 69-80 years, without known renal disease. BMD was measured with dual X-ray absorptiometry (DXA) in the hip and lumbar spine. Serum intact FGF23 was analyzed with a two-site monoclonal ELISA. There was a weak but significant correlation between FGF23 and BMD in femoral neck (r = 0.04, p < 0.05), femoral trochanter (r = 0.05, p = 0.004), total hip (r = 0.06, p = 0.0015) and lumbar spine (r = 0.07, p = 0.0004). The correlations remained significant when adjusting for biochemical covariates (Pi, calcium, PTH, 25(OH)D and renal function). However, the association became insignificant in all regions when adjusting for established confounding variables including age, height, weight and smoking. Further analysis confirmed a significant correlation between FGF23 and body weight (r = 0.13, p < 0.0001). The weak correlation between FGF23 and BMD in elderly male subjects is mainly due to an association between FGF23 and body weight. Therefore, FGF23 may not play a significant role in the hormonal regulation of BMD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone mineralization, FGF-23, Fibroblast growth, Growth factors, factor 23, Bone densitometry, BMD
in
Osteoporosis International
volume
20
issue
7
pages
1167 - 1173
publisher
Springer
external identifiers
  • wos:000266665800008
  • scopus:67349176732
ISSN
1433-2965
DOI
10.1007/s00198-008-0780-2
language
English
LU publication?
yes
id
3fb30015-bbaa-4d11-a782-70a3af8f4465 (old id 1443508)
date added to LUP
2009-07-24 12:50:37
date last changed
2017-10-29 03:54:40
@article{3fb30015-bbaa-4d11-a782-70a3af8f4465,
  abstract     = {We evaluated the relation between serum FGF23 and bone mineral density (BMD) in a community-based cohort of elderly men. There was a weak correlation between FGF23 and BMD, which was primarily dependent on body weight. FGF23 is a hormonal factor produced in bone and regulates serum levels of phosphate (Pi) and vitamin D. FGF23 over-expression is associated with skeletal abnormalities, including rickets/osteomalacia. The relation between FGF23 and Bone Mineral Density (BMD) in the community remains unexplored. We employed a large, population-based cohort of 3014 Swedish men aged 69-80 years, without known renal disease. BMD was measured with dual X-ray absorptiometry (DXA) in the hip and lumbar spine. Serum intact FGF23 was analyzed with a two-site monoclonal ELISA. There was a weak but significant correlation between FGF23 and BMD in femoral neck (r = 0.04, p &lt; 0.05), femoral trochanter (r = 0.05, p = 0.004), total hip (r = 0.06, p = 0.0015) and lumbar spine (r = 0.07, p = 0.0004). The correlations remained significant when adjusting for biochemical covariates (Pi, calcium, PTH, 25(OH)D and renal function). However, the association became insignificant in all regions when adjusting for established confounding variables including age, height, weight and smoking. Further analysis confirmed a significant correlation between FGF23 and body weight (r = 0.13, p &lt; 0.0001). The weak correlation between FGF23 and BMD in elderly male subjects is mainly due to an association between FGF23 and body weight. Therefore, FGF23 may not play a significant role in the hormonal regulation of BMD.},
  author       = {Marsell, R. and Mirza, M. A. I. and Mallmin, H. and Karlsson, Magnus and Mellstrom, D. and Orwoll, E. and Ohlsson, C. and Jonsson, K. B. and Ljunggren, O. and Larsson, T. E.},
  issn         = {1433-2965},
  keyword      = {Bone mineralization,FGF-23,Fibroblast growth,Growth factors,factor 23,Bone densitometry,BMD},
  language     = {eng},
  number       = {7},
  pages        = {1167--1173},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men},
  url          = {http://dx.doi.org/10.1007/s00198-008-0780-2},
  volume       = {20},
  year         = {2009},
}