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Maternal smoking during pregnancy and testicular cancer in the sons: A nested case-control study and a meta-analysis

Tuomisto, Jouko; Holl, Katsiaryna; Rantakokko, Panu; Koskela, Pentti; Hallmans, Goran; Wadell, Goran; Stattin, Par; Dillner, Joakim LU ; Ogmundsdottir, Helga M. and Vartiainen, Terttu, et al. (2009) In European Journal of Cancer 45(9). p.1640-1648
Abstract
Some large ecological studies have noted a significant association of testicular cancer (TC) with maternal smoking during pregnancy, while several more controlled studies have been negative. It has been difficult to obtain reliable data on exposure because of the long lag time to cancer diagnosis. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal smoking in the risk of TC in the offspring. After reviewing the literature, we also performed a meta-analysis of published studies. For each index mother of the TC patient, three to nine matched control mothers with a cancer-free son born at the same time as the TC case were... (More)
Some large ecological studies have noted a significant association of testicular cancer (TC) with maternal smoking during pregnancy, while several more controlled studies have been negative. It has been difficult to obtain reliable data on exposure because of the long lag time to cancer diagnosis. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal smoking in the risk of TC in the offspring. After reviewing the literature, we also performed a meta-analysis of published studies. For each index mother of the TC patient, three to nine matched control mothers with a cancer-free son born at the same time as the TC case were identified within each cohort. First trimester sera were retrieved from the 70 index mothers and 519 control mothers and were tested for cotinine level by a novel HPLC-MS-MS method developed. No statistically significant association between maternal cotinine level and risk of TC in the offspring was found (OR 0.68; 95% CI 0.35, 1.34). This is the first study based on individual exposure measurements. Its results agree with our meta-analysis of seven previous epidemiological studies (total number of 2149 cases, 2762 controls) using indirect exposure assessment (OR 1.0; 95% CI 0.88, 1.12). (c) 2009 Elsevier Ltd. All rights reserved. (Less)
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keywords
Offspring, Testicular cancer, Cotinine analysis, Cotinine, Maternal smoking, Pregnancy, Developmental effects
in
European Journal of Cancer
volume
45
issue
9
pages
1640 - 1648
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000266504100025
  • scopus:65849527385
ISSN
1879-0852
DOI
10.1016/j.ejca.2009.01.017
language
English
LU publication?
yes
id
c158b335-39c0-4f34-a157-198aa4da9e59 (old id 1443949)
date added to LUP
2009-07-17 12:18:23
date last changed
2017-01-01 04:23:31
@article{c158b335-39c0-4f34-a157-198aa4da9e59,
  abstract     = {Some large ecological studies have noted a significant association of testicular cancer (TC) with maternal smoking during pregnancy, while several more controlled studies have been negative. It has been difficult to obtain reliable data on exposure because of the long lag time to cancer diagnosis. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal smoking in the risk of TC in the offspring. After reviewing the literature, we also performed a meta-analysis of published studies. For each index mother of the TC patient, three to nine matched control mothers with a cancer-free son born at the same time as the TC case were identified within each cohort. First trimester sera were retrieved from the 70 index mothers and 519 control mothers and were tested for cotinine level by a novel HPLC-MS-MS method developed. No statistically significant association between maternal cotinine level and risk of TC in the offspring was found (OR 0.68; 95% CI 0.35, 1.34). This is the first study based on individual exposure measurements. Its results agree with our meta-analysis of seven previous epidemiological studies (total number of 2149 cases, 2762 controls) using indirect exposure assessment (OR 1.0; 95% CI 0.88, 1.12). (c) 2009 Elsevier Ltd. All rights reserved.},
  author       = {Tuomisto, Jouko and Holl, Katsiaryna and Rantakokko, Panu and Koskela, Pentti and Hallmans, Goran and Wadell, Goran and Stattin, Par and Dillner, Joakim and Ogmundsdottir, Helga M. and Vartiainen, Terttu and Lehtinen, Matti and Pukkala, Eero},
  issn         = {1879-0852},
  keyword      = {Offspring,Testicular cancer,Cotinine analysis,Cotinine,Maternal smoking,Pregnancy,Developmental effects},
  language     = {eng},
  number       = {9},
  pages        = {1640--1648},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Maternal smoking during pregnancy and testicular cancer in the sons: A nested case-control study and a meta-analysis},
  url          = {http://dx.doi.org/10.1016/j.ejca.2009.01.017},
  volume       = {45},
  year         = {2009},
}