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Circulating lipids and breast cancer prognosis in the Malmö diet and cancer study

Harborg, Sixten ; Ahern, Thomas P. ; Feldt, Maria LU ; Rosendahl, Ann H. LU ; Cronin-Fenton, Deirdre ; Melander, Olle LU orcid and Borgquist, Signe LU (2022) In Breast Cancer Research and Treatment 191(3). p.611-621
Abstract

Purpose: Examine the association between circulating lipids and breast cancer outcomes in patients enrolled in the Malmö Diet and Cancer Study (MDCS). Patients and methods: Circulating lipid levels were measured in blood sampled upon enrollment in the female MDCS cohort (N = 17,035). We identified all MDCS participants with incident invasive breast cancer diagnosed between 1991 and 2014. Follow-up time began at breast cancer diagnosis and continued until the first event of breast cancer recurrence, death, emigration, or 5 years of follow-up. We estimated the incidence rates of recurrence at 5 years and fit Cox regression models to compute crude and adjusted hazard ratios (HRs) with 95% confidence intervals (95% CI) of breast cancer... (More)

Purpose: Examine the association between circulating lipids and breast cancer outcomes in patients enrolled in the Malmö Diet and Cancer Study (MDCS). Patients and methods: Circulating lipid levels were measured in blood sampled upon enrollment in the female MDCS cohort (N = 17,035). We identified all MDCS participants with incident invasive breast cancer diagnosed between 1991 and 2014. Follow-up time began at breast cancer diagnosis and continued until the first event of breast cancer recurrence, death, emigration, or 5 years of follow-up. We estimated the incidence rates of recurrence at 5 years and fit Cox regression models to compute crude and adjusted hazard ratios (HRs) with 95% confidence intervals (95% CI) of breast cancer recurrence as well as all-cause mortality according to cohort-specific tertiles of apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B). Results: We enrolled 850 eligible patients. During the 5 years of follow-up, 90 invasive breast cancer recurrences were diagnosed over 3807 person-years. In multivariable analyses, high baseline levels of Apo B were associated with an increased rate of recurrence (tertile 3 vs. 1, HR = 2.30 [95% CI 1.13–4.68]). However, high baseline levels of Apo B were not associated with all-cause mortality (tertile 3 vs. 1, HR = 1.23 [95% CI 0.68–2.25]). We observed no associations between levels of Apo A-1 and recurrence (tertile 3 vs. 1, HR = 1.34 [95% CI 0.70–2.58]) or all-cause mortality (tertile 3 vs. 1, HR = 1.12 [95% CI 0.61–2.05]). Conclusion: High pre-diagnostic levels of Apo B were associated with an increased risk of recurrence among breast cancer patients. Circulating Apo A-1 was not associated with breast cancer outcomes.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
All-cause mortality, Apolipoprotein A1, Apolipoprotein B, Apolipoproteins, Breast cancer, Cancer, Circulating lipids, Cohort study, Distant recurrence, Dyslipidemia, Lipids, Loco-regional recurrence, Prognosis, Recurrence, Survival
in
Breast Cancer Research and Treatment
volume
191
issue
3
pages
611 - 621
publisher
Springer
external identifiers
  • pmid:34825306
  • scopus:85119846318
ISSN
0167-6806
DOI
10.1007/s10549-021-06462-7
language
English
LU publication?
yes
id
1443a5c5-71ac-420a-986b-6e6417b1a1d2
date added to LUP
2021-12-15 08:33:14
date last changed
2024-06-15 22:42:15
@article{1443a5c5-71ac-420a-986b-6e6417b1a1d2,
  abstract     = {{<p>Purpose: Examine the association between circulating lipids and breast cancer outcomes in patients enrolled in the Malmö Diet and Cancer Study (MDCS). Patients and methods: Circulating lipid levels were measured in blood sampled upon enrollment in the female MDCS cohort (N = 17,035). We identified all MDCS participants with incident invasive breast cancer diagnosed between 1991 and 2014. Follow-up time began at breast cancer diagnosis and continued until the first event of breast cancer recurrence, death, emigration, or 5 years of follow-up. We estimated the incidence rates of recurrence at 5 years and fit Cox regression models to compute crude and adjusted hazard ratios (HRs) with 95% confidence intervals (95% CI) of breast cancer recurrence as well as all-cause mortality according to cohort-specific tertiles of apolipoprotein A-1 (Apo A-1) and apolipoprotein B (Apo B). Results: We enrolled 850 eligible patients. During the 5 years of follow-up, 90 invasive breast cancer recurrences were diagnosed over 3807 person-years. In multivariable analyses, high baseline levels of Apo B were associated with an increased rate of recurrence (tertile 3 vs. 1, HR = 2.30 [95% CI 1.13–4.68]). However, high baseline levels of Apo B were not associated with all-cause mortality (tertile 3 vs. 1, HR = 1.23 [95% CI 0.68–2.25]). We observed no associations between levels of Apo A-1 and recurrence (tertile 3 vs. 1, HR = 1.34 [95% CI 0.70–2.58]) or all-cause mortality (tertile 3 vs. 1, HR = 1.12 [95% CI 0.61–2.05]). Conclusion: High pre-diagnostic levels of Apo B were associated with an increased risk of recurrence among breast cancer patients. Circulating Apo A-1 was not associated with breast cancer outcomes.</p>}},
  author       = {{Harborg, Sixten and Ahern, Thomas P. and Feldt, Maria and Rosendahl, Ann H. and Cronin-Fenton, Deirdre and Melander, Olle and Borgquist, Signe}},
  issn         = {{0167-6806}},
  keywords     = {{All-cause mortality; Apolipoprotein A1; Apolipoprotein B; Apolipoproteins; Breast cancer; Cancer; Circulating lipids; Cohort study; Distant recurrence; Dyslipidemia; Lipids; Loco-regional recurrence; Prognosis; Recurrence; Survival}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{611--621}},
  publisher    = {{Springer}},
  series       = {{Breast Cancer Research and Treatment}},
  title        = {{Circulating lipids and breast cancer prognosis in the Malmö diet and cancer study}},
  url          = {{http://dx.doi.org/10.1007/s10549-021-06462-7}},
  doi          = {{10.1007/s10549-021-06462-7}},
  volume       = {{191}},
  year         = {{2022}},
}