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Suspected infections in children treated for ALL

Hafsteinsdottir, Solveig; Jonasson, Kristjan; Jonmundsson, Guomundur K.; Kristinsson, Jon R.; Jonsson, Olafur Gisli; Alfreosdottir, Inga Huld; Cilio, Corrado LU ; Wiebe, Thomas LU and Haraldsson, Asgeir (2009) In Acta Pædiatrica 98(7). p.1149-1155
Abstract
The aim of our study was to get epidemiological information on bacterial infections in children treated for ALL and to analyse which patients have an enhanced infection risk. Episodes of suspected or confirmed infections were evaluated during the first 12 months of treatment for childhood acute lymphoblastic leukaemia (ALL). The number of patients was 73 (43 boys). The median age was 4.6 years. A total of 179 episodes occurred, varying from none in six patients to eight in one. Bacteria were cultured in 57 episodes (31.8%), the most common being coagulase-negative staphylococci. The number of episodes fell significantly with increasing age for suspected and confirmed infections (p < 0.001 and p = 0.03). The proportion of confirmed... (More)
The aim of our study was to get epidemiological information on bacterial infections in children treated for ALL and to analyse which patients have an enhanced infection risk. Episodes of suspected or confirmed infections were evaluated during the first 12 months of treatment for childhood acute lymphoblastic leukaemia (ALL). The number of patients was 73 (43 boys). The median age was 4.6 years. A total of 179 episodes occurred, varying from none in six patients to eight in one. Bacteria were cultured in 57 episodes (31.8%), the most common being coagulase-negative staphylococci. The number of episodes fell significantly with increasing age for suspected and confirmed infections (p < 0.001 and p = 0.03). The proportion of confirmed infections was significantly higher (p < 0.001) in the first episodes. The average number of suspected infections was higher in girls than in boys (p = 0.03), but confirmed infections were not. Most of the serious infections occur early in the treatment and the number of suspected and confirmed infections falls with age. Suspicion of infection is more likely in girls, but the number of confirmed infections is equal in both sexes. Coagulase-negative staphylococcus was most commonly isolated, highlighting the importance of careful handling of central venous devices. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Treatment, Leukaemia, ALL, Infection
in
Acta Pædiatrica
volume
98
issue
7
pages
1149 - 1155
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000266636400017
  • scopus:66749181108
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2009.01286.x
language
English
LU publication?
yes
id
e306245d-7c4c-4788-9776-9fb7a59367c3 (old id 1444175)
date added to LUP
2009-07-17 10:47:01
date last changed
2017-09-03 04:19:35
@article{e306245d-7c4c-4788-9776-9fb7a59367c3,
  abstract     = {The aim of our study was to get epidemiological information on bacterial infections in children treated for ALL and to analyse which patients have an enhanced infection risk. Episodes of suspected or confirmed infections were evaluated during the first 12 months of treatment for childhood acute lymphoblastic leukaemia (ALL). The number of patients was 73 (43 boys). The median age was 4.6 years. A total of 179 episodes occurred, varying from none in six patients to eight in one. Bacteria were cultured in 57 episodes (31.8%), the most common being coagulase-negative staphylococci. The number of episodes fell significantly with increasing age for suspected and confirmed infections (p &lt; 0.001 and p = 0.03). The proportion of confirmed infections was significantly higher (p &lt; 0.001) in the first episodes. The average number of suspected infections was higher in girls than in boys (p = 0.03), but confirmed infections were not. Most of the serious infections occur early in the treatment and the number of suspected and confirmed infections falls with age. Suspicion of infection is more likely in girls, but the number of confirmed infections is equal in both sexes. Coagulase-negative staphylococcus was most commonly isolated, highlighting the importance of careful handling of central venous devices.},
  author       = {Hafsteinsdottir, Solveig and Jonasson, Kristjan and Jonmundsson, Guomundur K. and Kristinsson, Jon R. and Jonsson, Olafur Gisli and Alfreosdottir, Inga Huld and Cilio, Corrado and Wiebe, Thomas and Haraldsson, Asgeir},
  issn         = {1651-2227},
  keyword      = {Treatment,Leukaemia,ALL,Infection},
  language     = {eng},
  number       = {7},
  pages        = {1149--1155},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Suspected infections in children treated for ALL},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2009.01286.x},
  volume       = {98},
  year         = {2009},
}