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Typical and atypical carcinoid tumors of the lung : a clinicopathological correlation of 783 cases with emphasis on histological features

Moran, Cesar A. ; Lindholm, Kaleigh E. ; Brunnström, Hans LU orcid ; Langman, Gerald ; Jang, Se Jin ; Spagnolo, Dominic ; Chai, Siaw Ming ; Laycock, Andrew ; Falconieri, Giovanni and Pizzolitto, Stefano , et al. (2020) In Human Pathology 98. p.98-109
Abstract

We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Of the histopathological features analyzed, the presence of mitotic activity of 4 mitoses or more per 2 mm2, necrosis, lymphatic invasion, and lymph node metastasis were identified as statistically significant. Tumors measuring 3 cm or more were also identified as statistically significant and correlated... (More)

We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Of the histopathological features analyzed, the presence of mitotic activity of 4 mitoses or more per 2 mm2, necrosis, lymphatic invasion, and lymph node metastasis were identified as statistically significant. Tumors measuring 3 cm or more were also identified as statistically significant and correlated with clinical outcomes. Based on our analysis, we consider that the separation of low- and intermediate-grade neuroendocrine neoplasms of the lung needs to be readjusted in terms of mitotic count as the risk of overgrading these neoplasms exceeds 10% under the current criteria. We also consider that tumor size is an important feature to be considered in the assessment of these neoplasms and together with the histological grade of the tumor offers important features that can be correlated with clinical outcomes.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atypical carcinoid, Carcinoid, Intermediate grade, Low grade, Lung, Neuroendocrine
in
Human Pathology
volume
98
pages
12 pages
publisher
Elsevier
external identifiers
  • scopus:85082724549
  • pmid:32145220
ISSN
0046-8177
DOI
10.1016/j.humpath.2020.02.005
language
English
LU publication?
yes
id
14489421-f537-47b2-8143-5fdff1648f86
date added to LUP
2020-04-17 15:22:03
date last changed
2025-04-17 18:15:31
@article{14489421-f537-47b2-8143-5fdff1648f86,
  abstract     = {{<p>We present 783 surgical resections of typical and atypical carcinoid tumors of the lung identified in the pathology files of 20 different pathology departments. All cases were critically reviewed for clinical and pathological features and further correlated with clinical outcomes. Long-term follow-up was obtained in all the patients and statistically analyzed to determine significance of the different parameters evaluated. Of the histopathological features analyzed, the presence of mitotic activity of 4 mitoses or more per 2 mm<sup>2</sup>, necrosis, lymphatic invasion, and lymph node metastasis were identified as statistically significant. Tumors measuring 3 cm or more were also identified as statistically significant and correlated with clinical outcomes. Based on our analysis, we consider that the separation of low- and intermediate-grade neuroendocrine neoplasms of the lung needs to be readjusted in terms of mitotic count as the risk of overgrading these neoplasms exceeds 10% under the current criteria. We also consider that tumor size is an important feature to be considered in the assessment of these neoplasms and together with the histological grade of the tumor offers important features that can be correlated with clinical outcomes.</p>}},
  author       = {{Moran, Cesar A. and Lindholm, Kaleigh E. and Brunnström, Hans and Langman, Gerald and Jang, Se Jin and Spagnolo, Dominic and Chai, Siaw Ming and Laycock, Andrew and Falconieri, Giovanni and Pizzolitto, Stefano and de Pellegrin, Alessandro and Medeiros, Filomena and Edmunds, Lilian and Catarino, Ana and Cunha, Fernando and Ro, Jae and Pina-Oviedo, Sergio and Torrealba, Jose and Coppola, Domenico and Petersson, Fredrik and Oon, Ming Lian and Elmberger, Goran and y Cajal, Santiago Ramon and Valero, Irene Sansano and Dalurzo, Liliana and Soares, Fernando and Campos, Antonio H. and Vranic, Semir and Skenderi, Faruk and Correa, Arlene M. and Sepesi, Boris and Rice, David and Mehran, Reza and Walsh, Garrett}},
  issn         = {{0046-8177}},
  keywords     = {{Atypical carcinoid; Carcinoid; Intermediate grade; Low grade; Lung; Neuroendocrine}},
  language     = {{eng}},
  pages        = {{98--109}},
  publisher    = {{Elsevier}},
  series       = {{Human Pathology}},
  title        = {{Typical and atypical carcinoid tumors of the lung : a clinicopathological correlation of 783 cases with emphasis on histological features}},
  url          = {{http://dx.doi.org/10.1016/j.humpath.2020.02.005}},
  doi          = {{10.1016/j.humpath.2020.02.005}},
  volume       = {{98}},
  year         = {{2020}},
}