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Harmonic microchip acoustophoresis: a route to online raw milk sample precondition in protein and lipid content quality control

Grenvall, Carl LU ; Augustsson, Per LU ; Folkenberg, Jacob Riis and Laurell, Thomas LU (2009) In Analytical Chemistry 81(15). p.6195-6200
Abstract
A microfluidic approach for raw milk sample preconditioning prior to protein and lipid content analysis has been developed. The system utilizes microchip acoustophoresis and is a further extension of our previously reported multiple node ultrasonic standing wave focusing platform ( Grenvall , C. , Augustsson , P. , Matsuoka , H. and Laurell , T. Proc. Micro Total Anal. Syst. 2008 , 1, 161-163 ). The microfluidic approach offers a method for rapid raw milk quality control using Fourier transform infrared spectroscopy (FT-IR). Two acoustophoresis modes are explored, 2 lambda/2 and 3 lambda/2, offering lipid content enrichment or depletion, respectively. Lipid content depletion above 90% was accomplished. FT-IR data on microchip-processed raw... (More)
A microfluidic approach for raw milk sample preconditioning prior to protein and lipid content analysis has been developed. The system utilizes microchip acoustophoresis and is a further extension of our previously reported multiple node ultrasonic standing wave focusing platform ( Grenvall , C. , Augustsson , P. , Matsuoka , H. and Laurell , T. Proc. Micro Total Anal. Syst. 2008 , 1, 161-163 ). The microfluidic approach offers a method for rapid raw milk quality control using Fourier transform infrared spectroscopy (FT-IR). Two acoustophoresis modes are explored, 2 lambda/2 and 3 lambda/2, offering lipid content enrichment or depletion, respectively. Lipid content depletion above 90% was accomplished. FT-IR data on microchip-processed raw milk samples, enabling direct lipid and protein content analysis, are reported. Most importantly, the harmonic operational modes bypass the problem of lipid aggregation and subsequent clogging, inherent in lambda/2 acoustophoresis systems. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Chemistry
volume
81
issue
15
pages
6195 - 6200
publisher
The American Chemical Society
external identifiers
  • wos:000268455600031
  • pmid:19572705
  • scopus:68049099248
ISSN
1520-6882
DOI
10.1021/ac900723q
language
English
LU publication?
yes
id
e8099634-0613-4617-8cc8-bd8a1865b448 (old id 1453450)
date added to LUP
2009-09-01 08:51:59
date last changed
2017-10-22 03:50:14
@article{e8099634-0613-4617-8cc8-bd8a1865b448,
  abstract     = {A microfluidic approach for raw milk sample preconditioning prior to protein and lipid content analysis has been developed. The system utilizes microchip acoustophoresis and is a further extension of our previously reported multiple node ultrasonic standing wave focusing platform ( Grenvall , C. , Augustsson , P. , Matsuoka , H. and Laurell , T. Proc. Micro Total Anal. Syst. 2008 , 1, 161-163 ). The microfluidic approach offers a method for rapid raw milk quality control using Fourier transform infrared spectroscopy (FT-IR). Two acoustophoresis modes are explored, 2 lambda/2 and 3 lambda/2, offering lipid content enrichment or depletion, respectively. Lipid content depletion above 90% was accomplished. FT-IR data on microchip-processed raw milk samples, enabling direct lipid and protein content analysis, are reported. Most importantly, the harmonic operational modes bypass the problem of lipid aggregation and subsequent clogging, inherent in lambda/2 acoustophoresis systems.},
  author       = {Grenvall, Carl and Augustsson, Per and Folkenberg, Jacob Riis and Laurell, Thomas},
  issn         = {1520-6882},
  language     = {eng},
  number       = {15},
  pages        = {6195--6200},
  publisher    = {The American Chemical Society},
  series       = {Analytical Chemistry},
  title        = {Harmonic microchip acoustophoresis: a route to online raw milk sample precondition in protein and lipid content quality control},
  url          = {http://dx.doi.org/10.1021/ac900723q},
  volume       = {81},
  year         = {2009},
}