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Allelic polymorphism in MHC class IIB in four populations of Atlantic salmon (Salmo salar)

Langefors, Åsa LU ; Lohm, Jakob LU and von Schantz, Torbjörn LU (2001) In Immunogenetics 53(4). p.329-336
Abstract
We sequenced exon 2 of the MHC class II B gene in Atlantic salmon from the Baltic Sea and identified 17 different exon 2 alleles among 22 different restriction fragment length polymorphism haplotypes. The sequences differed at between I and 34 bases. Two different tests were used to estimate the importance of recombination in the generation of new alleles. Recombination events appear to have occurred between three and nine times. Only two pairs of sequences differed by less than five nucleotides', minimizing the importance of point mutations for generating new alleles. Phylogenetic analysis showed that sequences did not cluster according to populations, and genetic distances between populations were small compared to those obtained by... (More)
We sequenced exon 2 of the MHC class II B gene in Atlantic salmon from the Baltic Sea and identified 17 different exon 2 alleles among 22 different restriction fragment length polymorphism haplotypes. The sequences differed at between I and 34 bases. Two different tests were used to estimate the importance of recombination in the generation of new alleles. Recombination events appear to have occurred between three and nine times. Only two pairs of sequences differed by less than five nucleotides', minimizing the importance of point mutations for generating new alleles. Phylogenetic analysis showed that sequences did not cluster according to populations, and genetic distances between populations were small compared to those obtained by allele frequency data. These results, together with the similarity found between exon 2 sequences from Baltic salmon and Norwegian salmon, indicate that all of the identified alleles were present in the ancient salmon population colonizing the Baltic rivers after the last glaciation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunogenetics
volume
53
issue
4
pages
329 - 336
publisher
Springer
external identifiers
  • scopus:0034911730
ISSN
1432-1211
DOI
10.1007/s002510100329
language
English
LU publication?
yes
id
a1d888fe-cd98-426d-a067-eabb47c1698d (old id 145744)
date added to LUP
2007-06-26 09:05:00
date last changed
2018-06-10 03:40:01
@article{a1d888fe-cd98-426d-a067-eabb47c1698d,
  abstract     = {We sequenced exon 2 of the MHC class II B gene in Atlantic salmon from the Baltic Sea and identified 17 different exon 2 alleles among 22 different restriction fragment length polymorphism haplotypes. The sequences differed at between I and 34 bases. Two different tests were used to estimate the importance of recombination in the generation of new alleles. Recombination events appear to have occurred between three and nine times. Only two pairs of sequences differed by less than five nucleotides', minimizing the importance of point mutations for generating new alleles. Phylogenetic analysis showed that sequences did not cluster according to populations, and genetic distances between populations were small compared to those obtained by allele frequency data. These results, together with the similarity found between exon 2 sequences from Baltic salmon and Norwegian salmon, indicate that all of the identified alleles were present in the ancient salmon population colonizing the Baltic rivers after the last glaciation.},
  author       = {Langefors, Åsa and Lohm, Jakob and von Schantz, Torbjörn},
  issn         = {1432-1211},
  language     = {eng},
  number       = {4},
  pages        = {329--336},
  publisher    = {Springer},
  series       = {Immunogenetics},
  title        = {Allelic polymorphism in MHC class IIB in four populations of Atlantic salmon (Salmo salar)},
  url          = {http://dx.doi.org/10.1007/s002510100329},
  volume       = {53},
  year         = {2001},
}