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Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Johnsen, Nina Fans ; Tjonneland, Anne ; Thomsen, Birthe L. R. ; Christensen, Jane ; Loft, Steffen ; Friedenreich, Christine ; Key, Timothy J. ; Allen, Naomi E. ; Lahmann, Petra H. and Mejlvig, Lotte , et al. (2009) In International Journal of Cancer 125(4). p.902-908
Abstract
The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a... (More)
The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (p(trend) = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity. (C) 2009 UICC (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prostate cancer, physical activity, exercise, cohort
in
International Journal of Cancer
volume
125
issue
4
pages
902 - 908
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000268287700020
  • scopus:67650071228
ISSN
0020-7136
DOI
10.1002/ijc.24326
language
English
LU publication?
yes
id
147486c8-a85d-4f11-9a97-9c2176f9e0cc (old id 1460547)
date added to LUP
2016-04-01 12:15:02
date last changed
2021-09-01 02:10:37
@article{147486c8-a85d-4f11-9a97-9c2176f9e0cc,
  abstract     = {The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. In our study, including 127,923 men aged 20-97 years from 8 European countries, 2,458 cases of prostate cancer were identified during 8.5 years of followup. Using the Cox proportional hazards model, we investigated the associations between prostate cancer incidence rate and occupational activity and leisure time activity in terms of participation in sports, cycling, walking and gardening; a metabolic equivalent (MET) score based on weekly time spent on the 4 activities; and a physical activity index. MET hours per week of leisure time activity, higher score in the physical activity index, participation in any of the 4 leisure time activities, and the number of leisure time activities in which the participants were active were not associated with prostate cancer incidence. However, higher level of occupational physical activity was associated with lower risk of advanced stage prostate cancer (p(trend) = 0.024). In conclusion, our data support the hypothesis of an inverse association between advanced prostate cancer risk and occupational physical activity, but we found no support for an association between prostate cancer risk and leisure time physical activity. (C) 2009 UICC},
  author       = {Johnsen, Nina Fans and Tjonneland, Anne and Thomsen, Birthe L. R. and Christensen, Jane and Loft, Steffen and Friedenreich, Christine and Key, Timothy J. and Allen, Naomi E. and Lahmann, Petra H. and Mejlvig, Lotte and Overvad, Kim and Kaaks, Rudolf and Rohrmann, Sabine and Boing, Heiner and Misirli, Gesthimani and Trichopoulou, Antonia and Zylis, Dimosthenis and Tumino, Rosario and Pala, Valeria and Bueno-de-Mesquita, H. Bas and Kiemeney, Lambertus A. and Rodriguez Suarez, Laudina and Gonzalez, Carlos A. and Sanchez, Maria-Jose and Maria Huerta, Jose and Barricarte Gurrea, Aurelio and Manjer, Jonas and Wirfält, Elisabet and Khaw, Kay-Tee and Wareham, Nick and Boffetta, Paolo and Egevad, Lars and Rinaldi, Sabina and Riboli, Elio},
  issn         = {0020-7136},
  language     = {eng},
  number       = {4},
  pages        = {902--908},
  publisher    = {John Wiley & Sons Inc.},
  series       = {International Journal of Cancer},
  title        = {Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort},
  url          = {http://dx.doi.org/10.1002/ijc.24326},
  doi          = {10.1002/ijc.24326},
  volume       = {125},
  year         = {2009},
}